A5025998709- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Peripheral Neuropathies and Disorders
- Menopause: Health Impacts and Treatments
- Innovations in Medical Education
- Cardiovascular and Diving-Related Complications
- Liver Diseases and Immunity
- Nursing Education, Practice, and Leadership
- Disaster Management and Resilience
- Cytokine Signaling Pathways and Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Platelet Disorders and Treatments
- Drug-Induced Ocular Toxicity
- Urticaria and Related Conditions
- Academic Writing and Publishing
- Apelin-related biomedical research
- Health Literacy and Information Accessibility
- Estrogen and related hormone effects
- Dental Education, Practice, Research
- Hemophilia Treatment and Research
Duke University
2019-2024
Rogers (United States)
2020-2024
Murray State University
2024
Duke University Hospital
2021-2024
Duke Medical Center
2020-2024
Wellcome Centre for Human Neuroimaging
2024
King's College London
2024
Dominican University of California
2020
Estée Lauder (United States)
2020
University of North Carolina at Chapel Hill
2012-2016
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Objective In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), SLE represents classic inflammatory manifestations, such as arthritis, while encompasses symptoms pain and fatigue where relationship to inflammation is less clear. The objective of this study was interview individuals living with determine content face validity model. Methods We conducted a qualitative using semi-structured interviews purposeful sample participants who met classification criteria SLE....
Medication nonadherence is more common in African Americans compared with Caucasians. We examined the racial adherence gaps among patients systemic lupus erythematosus (SLE) and explored factors associated nonadherence.Cross-sectional data were obtained from consecutive prescribed SLE medications seen at an academic clinic between August 2018 February 2019. Adherence was measured using both self-report pharmacy refill data. High composite defined as having high self-reported rates....
Abstract Apoptotic debris, autoantibody, and IgG–immune complexes (ICs) have long been implicated in the inflammation associated with systemic lupus erythematosus (SLE); however, it remains unclear whether they initiate immune-mediated events that promote disease. In this study, we show PBMCs from SLE patients experiencing active disease, hematopoietic cells lupus-prone MRL/lpr NZM2410 mice accumulate markedly elevated levels of surface-bound nuclear self-antigens. On dendritic (DCs)...
Despite significant racial disparities in systemic lupus erythematosus (SLE) outcomes, few studies have examined how may be perpetuated clinical encounters. We aimed to explore associations between areas of encounters - patient-provider communication and patient self-efficacy with SLE-related damage, order identify potential for intervention reduce SLE outcome disparities.We collected cross-sectional data from a tertiary clinic including communication, general self-efficacy, managing...
Objective We developed a model that categorizes systemic lupus erythematosus (SLE) activity into two dimensions: Type 1 SLE consists of inflammatory activity, including arthritis, nephritis, and rashes; 2 includes fatigue, myalgia, mood disturbance, cognitive dysfunction. Patient-reported outcome (PRO) measures have received attention as way to capture symptomatology SLE. The objective this study was explore the use existing PRO classify activity. Methods Systemic patients completed three...
Objective Medication nonadherence in systemic lupus erythematosus (SLE) leads to poor clinical outcomes. We developed a clinician-led adherence intervention that involves reviewing real-time pharmacy refill data and using effective communication address nonadherence. Prior pilot testing showed promising effects on medication adherence. Here, we describe further evaluation of how clinicians implemented the identify areas for improvement. Methods audio recorded encounters with patients who...
This report describes the implementation and evaluation of Bronx-Lebanon Hospital Center Dental Faculty Development Program (DFDP) for fifteen participants: five advanced dental education faculty members ten residents. The 100-hour DFDP, designed in longitudinal immersion model development, was conducted four phases at Department Dentistry Bronx, New York, 2010-11. DFDP implemented to help underrepresented minority (URM) residents clinical develop skills necessary academic careers enhanced...
To account for heterogeneity in systemic lupus erythematosus (SLE) and bridge discrepancies between patient- physician-perceived SLE activity, we developed the Type 1 2 model. We examined PROMIS-29 scores, a composite patient-reported outcome (PRO) measure, through lens of
Evidence suggests low health literacy is prevalent in the United States and associated with worse clinical outcomes, yet few studies have investigated systemic lupus erythematosus (SLE). The objective of this study was to determine prevalence numeracy patients examine its association disease characteristics.Patients SLE were recruited from an academic center clinic. Participants completed in-person assessments (Rapid Estimate Adult Literacy Medicine, REALM) (Numeracy Understanding Medicine...
<h3>Background</h3> The physician global assessment (PGA) is a 3-point visual analog scale assessing lupus disease activity. We implemented Type II PGA to assess what we have termed SLE symptoms. symptoms encompass fatigue, widespread pain, depression, sleep and cognitive dysfunction, differ from I symptoms, such as nephritis inflammatory arthritis, the classic manifestations of inflammation. <h3>Methods</h3> This was cross sectional study patients (ACR 1997 or SLICC 2012 criteria). All...
Limited health literacy and numeracy are associated with worse patient-reported outcomes higher disease activity in systemic lupus erythematosus (SLE), but which factors may mediate this association is unknown. We sought to determine the of SLE knowledge.Patients were recruited from an academic center clinic. Participants completed validated assessments (Newest Vital Sign [NVS]; n = 96) (Numeracy Understanding Medicine Instrument, Short Version [S-NUMI]; 85). They also Lupus Knowledge...
<h3>Background</h3> Patients with SLE experience distressing fibromyalgia-like symptoms of fatigue, widespread pain, mood disturbance, and brain fog that negatively impact quality life are challenging to manage. These symptoms, termed Type 2 SLE, can be related inflammatory non-inflammatory etiologies. Studies fibromyalgia suggest addressing biopsychosocial factors improve life. A Consortium was created bring together a multidisciplinary team patients clinicians develop equitable, feasible,...
<h3></h3> Endosomes and lysosomes (endo-lysosomes) play a central role in maintaining cellular homeostasis by degrading extracellular obsolete intracellular waste through their ability to acidify activate acid hydrolases. Our previous studies identified that lysosomal acidification is diminished lupus-prone mice (NZM2410 MRL/<i>lpr</i>), promoting the accumulation of undegraded IgG-immune complexes (IgG-ICs) endocytic pathway. This triggers exocytosis, process where endo-lysosomes migrate...
Objective: In the outpatient setting, polypharmacy and poor communication among providers has left a gap in drug education involving elderly population. Linking all of these with an accurate medication regimen may be answer. Nurses can play pivotal role drug-related problems The aim this study is to use liaison nurse help educate population on importance adherence understanding their medications by using individualized card.Methods: This used descriptive design. A convenience sample (n = 16)...
Medication nonadherence is common in patients with systemic lupus erythematosus (SLE) and negatively affects outcomes. To better recognize address this population, there a need for an easily implementable tool interpretable scores. Domains of Subjective Extent Nonadherence (DOSE-Nonadherence) measure that captures both extent reasons nonadherence. We refined evaluated DOSE-Nonadherence SLE.
Acquired inhibitors of coagulation are antibodies that interfere with the system either by functional inhibition activity clotting factors or their increased clearance from plasma. They can be idiopathic seen in various physiologic (pregnancy and postpartum) pathologic states (systemic lupus erythematosus (SLE), malignancies, rheumatoid arthritis) result a variety haemorrhagic sequelae. SLE associated to multiple bleeding though rare an important haematologic manifestation life-threatening...
Decreases in circulating estrogen seen human female diabetics may exacerbate vascular impairment the hyperglycemic state alone. E2s role as a vasoprotective agent is not clear. In normal animals, we and others have shown that E2 increases NO production while decreases sensitivity to vasodilator ACh vasoconstrictor PE. To examine whether there dysregulation of affect diabetic (D) vasculature, diabetes was induced by STZ injection adult rats concurrent with ovariectomy (OVX) replacement. After...