A5046418329- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Atomic and Subatomic Physics Research
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Mechanical Circulatory Support Devices
- Muscle metabolism and nutrition
- Neonatal and Maternal Infections
- GDF15 and Related Biomarkers
- Cardiovascular Conditions and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Respiratory Support and Mechanisms
University Hospital Bonn
2019-2025
German Center for Neurodegenerative Diseases
2020-2025
University of Bonn
2019-2024
University of Stavanger
2024
The Bronx Defenders
2024
Albert Einstein College of Medicine
2024
University of Oslo
2012-2023
University of Duisburg-Essen
2018-2022
Heinrich Heine University Düsseldorf
2010-2019
Düsseldorf University Hospital
2010-2019
<b><i>Objective:</i></b> Therapeutic hypothermia (HT) is the standard treatment for newborns after perinatal asphyxia. Preclinical studies report that HT more effective when started early. <b><i>Methods:</i></b> Eighty cooled were analyzed and grouped according to cooling was birth: early (≤180 min) or late (>181 min). For survivors we whether starting associated with a better psychomotor mental developmental index (PDI MDI, Bayley Scales of...
Hypothermia (HT) for neonatal hypoxic-ischemic encephalopathy is advised to start within the first 6 hours after birth. There some clinical evidence that HT more effective against moderate than severe encephalopathy, but it unknown whether delayed beyond or even injurious.One-hundred seven 7-day-old rat pups underwent unilateral hypoxia-ischemia of severity. Pups were randomized receive 5 normothermia (NT) starting immediately, 3 hours, 12 90-minute hypoxic period. One-hundred five lasting...
Therapeutic hypothermia has become standard of care in newborns with moderate and severe neonatal encephalopathy; however, additional interventions are needed. In experimental models, breathing xenon gas during cooling offers long-term additive neuroprotection. This is the first feasibility study cooled infants. Xenon expensive, requiring a closed-circuit delivery system.Cooled encephalopathy were eligible for this single-arm, dose-escalation if clinically stable, under 18 hours age less...
Abstract Therapeutic hypothermia (HT) is standard care for moderate and severe neonatal hypoxic-ischaemic encephalopathy (HIE), the leading cause of permanent brain injury in term newborns. However, optimal temperature HT still unknown, few preclinical studies have compared multiple treatment temperatures. Additionally, may not benefit infants with encephalopathy. In a rat model unilateral hypoxia-ischaemia (HI), effect five different temperatures was investigated after either or injury. At...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Acute hypothermia treatment (HT) is the only clinically established intervention following neonatal hypoxic-ischemic brain injury. However, almost half of all cooled infants still die or suffer from long-lasting neurological impairments. Regenerative therapies, such as mesenchymal stem cells (MSC) appear promising adjuvant therapy. In present study, we hypothesized that HT combined with delayed MSC therapy results in augmented protection, improving long-term outcome. Postnatal day 9 (P9)...
Perinatal asphyxia, leading to neonatal encephalopathy, is one of the causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are significantly increased in newborns with perinatal infection. Therapeutic hypothermia only neuroprotective 50% cooled asphyxiated newborns. As shown experimentally, cooling has failed be after inflammation-sensitized hypoxic ischemic (HI) brain injury. Microglia thought key players HI We performed this study investigating early...
Background: Microglia are key mediators of inflammation during perinatal brain injury. As shown experimentally after inflammation-sensitized hypoxic ischemic (HI) injury, microglia activated into a pro-inflammatory status 24 h HI involving the NLRP3 inflammasome pathway. The chemokine (C-X-C motif) ligand 1 (CXCL1), and its cognate receptor, CXCR2, have been to be involved in activation, although their specific role injury remains unclear. In this study we investigated involvement...
Abstract Among children, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are typically mild. Here, we describe the case of a 3.5-year-old girl with an unusually presentation disease (COVID-19). The child had autoinflammatory disorder unknown etiology, which been treated using prednisolone and methotrexate, her parents were half cousins Turkish descent. After 5 days nonspecific viral infection symptoms, tonic-clonic seizures occurred followed by cardiac insufficiency,...
Intrapartum hypoxia-ischemia leading to neonatal encephalopathy (NE) results in significant mortality and morbidity worldwide, with > 85% of cases occurring low- middle-income countries (LMIC). Therapeutic hypothermia (HT) is currently the only available safe effective treatment HIE high-income (HIC); however, it has shown limited safety or efficacy LMIC. Therefore, other therapies are urgently required. We aimed compare effects putative neuroprotective drug candidates following...
Importance One of the biggest challenges when using anti–vascular endothelial growth factor (VEGF) agents to treat retinopathy prematurity (ROP) is need perform long-term follow-up examinations identify eyes at risk ROP reactivation requiring retreatment. Objective To evaluate whether an artificial intelligence (AI)–based vascular severity score (VSS) can be used analyze regression and after anti-VEGF treatment potentially Design, Setting, Participants This prognostic study was a secondary...
Perinatal infection increases the vulnerability of neonatal brain to hypoxic-ischaemic (HI) injury. Hypothermia treatment (HT) does not provide neuroprotection after pre-insult inflammatory sensitisation by lipopolysaccharide (LPS), a gram-negative bacterial wall constituent. However, early-onset sepsis in term babies is caused gram-positive species more than 90% cases, and neuro-inflammatory responses triggered through route (Toll-like receptor 4, TLR-4) are different from those induced via...
<b><i>Introduction:</i></b> Bacterial lipopolysaccharide (LPS) injection prior to hypoxia-ischaemia significantly increases hypoxia-ischaemic brain injury in 7-day-old (P7) rats. In addition, therapeutic hypothermia (HT) is not neuroprotective this setting. However, the mechanistic aspects of failure have yet be elucidated. This study was designed investigate underlying cellular mechanisms double-hit model infection-sensitised injury. <b><i>Material and...
The peripheral immune system plays a critical role in neuroinflammation of the central nervous after an insult. Hypoxic-ischemic encephalopathy (HIE) induces strong neuroinflammatory response neonates, which is often associated with exacerbated outcomes. In adult models ischemic stroke, neutrophils infiltrate injured brain tissue immediately insult and aggravate inflammation via various mechanisms, including neutrophil extracellular trap (NETs) formation. this study, we used neonatal model...
BackgroundMagnetic Resonance (MR) imaging is key for investigation of suspected newborn brain abnormalities. Access limited in low-resource settings and challenging infants needing intensive care. Portable ultralow field (ULF) MRI showing promise bedside adult imaging. Use children has been as brain-tissue composition differences necessitate sequence modification. The aim this study was to develop neonatal-specific ULF structural sequences test these across a range gestational maturities...
Abstract The detection of transient peri‐ictal magnetic resonance imaging (MRI) abnormalities has been variable after epileptic seizures. most common reason for this variability is that may disappear if the interval between seizure and scan acquisition prolonged using conventional high‐field systems. Here, we deployed a portable ultra‐low‐field MRI system in presurgical evaluation at bedside individuals with epilepsy. We hypothesized novel technology enables rapid postictal scans reliably...
Congenital hydrocephalus is an increasing condition both in high as low and middle income countries. Main causes include aqueductal stenosis, neonatal central nervous system infections, intracranial hemorrhage, malformations tumors. Investigation of its etiology should magnetic resonance imaging (MRI) to detect especially pathologies the fossa cranii posterior. However, MRI not available every infant presenting with congenital those countries highest prevalence. New portable ultralow-field...
Abstract Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy of HT in preclinical models, such as Vannucci model unilateral HI newborn rat, often greater than that reported from clinical trials. Here, we report a meta-analysis data every experiment single laboratory, including pilot data, examining effect model. Across 21 experiments using 106 litters, median (95% CI) hemispheric area loss was 50.1% (46.0–51.9%; n =...