A5010091580- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Child Nutrition and Water Access
- Acute Ischemic Stroke Management
- Rabies epidemiology and control
- Bioactive Natural Diterpenoids Research
- Spinal Dysraphism and Malformations
- Lung Cancer Treatments and Mutations
- Systemic Lupus Erythematosus Research
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 detection and testing
- Sepsis Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Global Cancer Incidence and Screening
- Venomous Animal Envenomation and Studies
- Lung Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Genetic and Kidney Cyst Diseases
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
Christian Medical College & Hospital
2017-2025
Christian Medical College
2017-2024
Korle Bu Teaching Hospital
2024
The University of Melbourne
2024
Rajalakshmi Engineering College
2024
Medway NHS Foundation Trust
2023
Digital Research Alliance of Canada
2023
Creative Commons
2022
Basildon and Thurrock University Hospitals NHS Foundation Trust
2021
National Records of Scotland
2021
ABSTRACT Background Treatment of COVID-19 patients with plasma containing anti-SARS-CoV-2 antibodies may have a beneficial effect on clinical outcomes. We aimed to evaluate the safety and efficacy convalescent in admitted hospital COVID-19. Methods In this randomised, controlled, open-label, platform trial (Randomised Evaluation Therapy [RECOVERY]) several possible treatments are being compared usual care hospitalised UK. Eligible consenting were randomly allocated receive either plus high...
Abstract Prospective and sequential evaluation of homeostatic changes leading to thrombosis across COVID 19 disease severity spectrum are limited. In this prospective observational study, haemostasis was evaluated in patients with mild, moderate-severe, critical COVID-19 infection. Markers endothelial activation [Soluble thrombomodulin (sTM), von Willebrand Factor (VWF)], platelet P-selectin, beta-thromboglobulin (BTG)] global [Rotational thromboelastometry (ROTEM)] were on days 1 5 after...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted cross-sectional study to describe the clinical immunological profile patients MCTD compare four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, Khan criteria. A total 291 who were admitted from June 2007 2017 fulfilled inclusion criteria included in study. diagnosis made 111 patients,...
SUMMARY Background Colchicine has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory actions. Methods In this randomised, controlled, open-label trial, several possible treatments were compared with usual care in patients hospitalised COVID-19. Eligible and consenting adults randomly allocated 1:1 ratio to either standard alone or plus colchicine twice daily 10 days until discharge (or one other arms) using web-based simple (unstratified) randomisation allocation...
There is a high burden of stroke, including recurrent in India. We aimed to assess the effect structured semi-interactive stroke prevention package patients with subacute reduce strokes, myocardial infarction, and death.This was multicentre, randomised, clinical trial conducted 31 centres Indian Stroke Clinical Trial Network (INSTRuCT). Adult first access mobile cellular device were randomly allocated (1:1) intervention control groups by research coordinators at each centre using central,...
Extranodal involvement in lymphomas is well-documented the literature. However, certain anatomical sites, such as epidural space, are rarely affected by lymphoproliferative neoplasms. When confined to space without other recognisable sites of at diagnosis, they classified primary spinal lymphoma. We report case a man his early 30s who presented with lower back pain and progressive quadriparesis. Imaging revealed an extradural mass extending from sixth tenth thoracic vertebrae, lateral...
Context: Skull base osteomyelitis (SBO) is an uncommon disease with substantial morbidity and mortality. Aims: The aim of this study to characterize clinical features, outcomes, complications SBO. We also looked at differences in profile otogenic non-otogenic Materials Methods: This a single-center retrospective observational study. Patients aged more than 15 years age radiological diagnosis SBO admitted general medicine department teaching hospital South India from March 2006 February 2018...
Abstract Background The role and performance of various serological tests for the diagnosis COVID-19 are unclear. This study aimed to evaluate seven commercially available assays SARS-CoV-2 antibodies by testing cases controls. Methods Adult patients with fever > 5 days, admitted a tertiary-care teaching hospital in South India, were enrolled prospectively between June December 2020. RT-PCR confirmed classified as cases, febrile illness laboratory-confirmed alternative healthy...
Background: Behavioral and geographical factors may play a role in the acquisition of scrub typhus infection. In this prospective case–control study, we studied associated with Patients Methods: Consecutive adult patients admitted infection over 10 months were recruited. For every case, control from same area gender-matched clinical acute febrile illness enrolled. The risk factors, which included sanitation, environment, activity, protective measures, compared between cases controls using...
Scorpion bites are a common problem in Southern parts of India. The sting Mesobuthus tamulus belonging to the Buthidae family is known for being fatal. toxidrome scorpion its effect on cardiovascular system, and there have been rare reports cerebrovascular accidents as well. We describe case lateral medullary syndrome secondary sting. As per knowledge authors, this first report same.
Abstract Background Neurological complications following snake and scorpion bite are diverse. Literature regarding patterns of cerebrovascular injury (CVI) outcomes among these patients is scarce. This a descriptive study the clinical profile, brain imaging findings, mechanisms injury, vascular territory involvement CVI envenomation, in tertiary care center South India. Methodology Patients with sting- envenomation-related were retrospectively enrolled. Neuroimaging was performed on five...
The Covid-19 pandemic had a tremendous impact that caused significant morbidity, mortality, and financial stress for families. Our study aimed to determine the Out-of-pocket expenses economic of illness households where patients were admitted private hospital in India.This was cost-of-illness from tertiary care academic institute adult diagnosed with COVID-19 May 2020 June 2021 included. Patients an admission less than one day or who any form insurance excluded. clinical details obtained...
Multimorbidity, the coexistence of two or more chronic conditions in same individual, is a major public health problem low-income and middle-income countries (LMICs). The use single-disease guidelines contributes to polypharmacy, fragmented care increased treatment burden. Health systems LMICs are very different from those high-income countries, adapting interventions one other may not be feasible. This review aims systematically present current evidence for multimorbidity LMIC setting. In...
: Acute kidney injury (AKI) has been identified as an independent risk factor for mortality in intensive care units. This retrospective study was conducted to determine the effect of AKI on in-hospital a general medical ward tertiary hospital and factors patients with AKI.: Demographic clinical details, outcome data were collected from case records patients. In all hospitalized patients, associated increased mortality, such AKI, inotrope requirement, mechanical ventilation primary disease...
Acanthamoeba are ubiquitous free-living amoeba. infections cause necrotizing vasculitis, resulting in vessel thrombosis and cerebral infarction. CNS infections, though uncommon, associated with high mortality. Diagnosis is difficult often delayed. Here, we present two immunocompetent hosts encephalitis good outcomes.
Although studies have described the clinical profile of patients admitted to intensive care unit (ICU) with tuberculosis, it is unclear if type tuberculosis (pulmonary, extrapulmonary, or disseminated) impacts outcome.Demographic data, microbiology, treatment, and outcomes over 5 years (2012-16) were obtained from electronic records. Patients categorized as pulmonary, disseminated tuberculosis. Comparisons done using t test Fisher's exact appropriate. Predictors outcome explored bivariate...
Rhino-orbito-cerebral-mucormycosis (ROCM), a rare and potentially fatal disease was seen in increasing numbers during the COVID-19 pandemic. This study describes compares patient characteristics outcomes associated mucormycosis (CAM) non-COVID-19 (non-CAM).CAM patients (24 cases) were recruited from period non-CAM controls) pre-COVID-19 period. Clinical data of CAM group collected retrospectively with 3 month prospectively. The retrospectively. Patient compared risk factors for mortality...
Background and Purpose: Very few large scale multicentric stroke clinical trials have been done in India. The Indian Council of Medical Research funded INSTRuCT (Indian Stroke Clinical Trial Network) as a task force project with the objectives to establish state-of-the-art trial network conduct pharmacological nonpharmacological relevant nation globally. purpose article is enumerate structure network, emphasis on its scope, challenges expectations Methods: Multiple expert group meetings were...
Background: Systemic lupus erythematosus (SLE), a rare multisystem disorder with female preponderance, has high cost for the care; however, there is no evidence relevant to Indian setting. The primary objective of our study was determine financial burden index admission (IA) and subsequent costs during follow-up ascertain proportion catastrophic health expenditure (CHE). Methodology: This an observational retrospective cohort where inpatients general medicine ward were recruited from January...
Abstract Background: Thrombocytopenia has been well established in dengue infections; however, coagulopathy is yet to be explored. Objective: The primary outcome was assess derangement of activated partial thromboplastin time (aPTT) as a predictor bleeding manifestations and severity disease dengue. Methods: This prospective cohort study included adults with fever confirmed by serology, presenting single tertiary care center South India. A structured questionnaire used extract clinical...
Saliva, a non-invasive oral biofluid, offers rich source of biomarkers, akin to those found in blood. The advent biosensors has facilitated the transition from invasive diagnostics. current study explores potential microfluidic biosensor by targeting interleukin-8, biomarker for cancer towards immobilized antibodies on biosensor. Simulation studies probed into antigen-antibody binding kinetics 2D and 3D environments, COMSOL MultiphysicsTM software. parameters taken consideration include...