A5087505937- Antifungal resistance and susceptibility
- Infectious Diseases and Tuberculosis
- Fungal Infections and Studies
- Infectious Encephalopathies and Encephalitis
- COVID-19 Clinical Research Studies
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Burkholderia infections and melioidosis
- Neurofibromatosis and Schwannoma Cases
- Bacterial Infections and Vaccines
- Amoebic Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Mosquito-borne diseases and control
- Tuberculosis Research and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Metabolism and Genetic Disorders
- Phytoplasmas and Hemiptera pathogens
- Pituitary Gland Disorders and Treatments
- Health disparities and outcomes
- Brucella: diagnosis, epidemiology, treatment
- Bone health and treatments
- Female Genital Mutilation/Cutting Issues
- Venomous Animal Envenomation and Studies
Christian Medical College & Hospital
2015-2025
Christian Medical College
2005-2025
Background Cryptococcal meningitis continues to be one of the common causes chronic central nervous system infection worldwide. Individuals with cryptococcal can occasionally present small vessel vasculitis causing infarcts primarily in basal ganglia, internal capsule, and thalamus. Literature regarding patterns cerebrovascular injury among patients is scanty, outcome following these vascular involvements unknown. Aim To study clinical profile, imaging findings, details territory involved...
This study was performed to assess the risk factors driving epidemic of coronavirus disease 2019 (COVID-19)-associated mucormycosis (COVID–Mucor) in India that has accompanied COVID-19 pandemic, particularly during second wave. Risk were analysed among 164 participants: 132 COVID–Mucor (cases) and 32 non-COVID–Mucor (controls). Data from a prospective cohort over period 1 year used. Diabetes mellitus remained significant factor both groups (97%), while uncontrolled diabetes (odds ratio (OR)...
Abstract Background Few treatment options exist for patients with severe central nervous system (CNS) tuberculosis (TB) worsening due to inflammatory lesions, despite optimal antitubercular therapy (ATT) and steroids. Data regarding the efficacy safety of infliximab in these are sparse. Methods We performed a matched retrospective cohort study based on Medical Research Council (MRC) grading modified Rankin Scale (mRS) scores comparing 2 groups adults CNS TB. Cohort A received at least 1 dose...
Antiphospholipid antibody syndrome (APS) may rarely present with isolated thrombocytopenia that be diagnosed and treated as immune thrombocytopenic purpura. A 32-year-old woman was given eltrombopag (a thrombopoietin receptor agonist) to treat presumed She developed catastrophic APS, multiple ischaemic infarcts, microvascular coronary thrombosis digital gangrene. improved after stopping starting immunotherapy (corticosteroids, intravenous immunoglobulin rituximab) but left significant...
The optimal management of large tuberculous mass lesions (LTML) involving the central nervous system remains unclear. We conducted a single-center, retrospective, observational study that assessed outcomes patients with LTML from January 2010 to February 2023. An was defined as tuberculoma or tubercular abscess exceeding equal 3 cm. primary outcome independence in activities daily living, by modified Rankin Scale (mRS) at follow-up 6 months. Forty-six were identified during period. Their...
Temporal lobe epilepsy (TLE) is the most prevalent form of human epilepsy, often accompanied by neurodegeneration in hippocampus. Like other neurological diseases, TLE expected to disrupt lipid homeostasis. However, architecture brain relatively understudied, and molecular mechanism epileptogenesis poorly understood. We performed desorption electrospray ionization mass spectrometry imaging 39 fresh frozen surgical specimens hippocampus investigate profiles with hippocampal sclerosis (n = 14)...
To evaluate the efficacy and safety of short-course intravenous amphotericin B followed by sustained release posaconazole tablets for diabetes or COVID-19-associated rhino-orbito-cerebral mucormycosis.This prospective, pragmatic study included adults with mucormycosis. Patients received short (7-14 days) long (15-28 antifungal therapy (short treatment [SHIFT] [LIFT], respectively) depending on presence absence brain involvement. All patients step-down tablets, debridement, glycemic control....
Dengue is a common arboviral disease, which uncommonly involves the brain. There has been recent surge in dengue cases and dengue-related deaths tropical countries. The aim of this study was to describe brain imaging findings patients with infection having neurologic symptoms.Thirty-five positive serology for CNS symptoms undergoing were included study. Clinical, laboratory, parameters assessed correlated poor outcome.A Glasgow Coma Scale score ≤12 at presentation, clinical classification...
Visual disturbances including visual loss have been reported in up to 40% of patients with cryptococcal meningitis (CCM).[1],[2] However, there are no clear guidelines regarding the diagnosis, follow-up, and management complications CCM. Formulation evidence-based has limited by incomplete understanding its pathogenesis. We aimed evaluate prevalence CCM association clinical radiological features raised intracranial pressure (ICP).
A 59-year-old man without any previous vascular risk factors presented with 3-month duration of headache and gradual worsening his sensorium. At the time presentation, he had a low Glasgow coma scale (10/15) neck stiffness; remaining clinical examination was unremarkable. On initial evaluation, diagnosed to have HIV infection CD4 count 43 cells/uL. His serum venereal disease research laboratory nonreactive. cerebrospinal fluid (CSF) showed lymphocytic pleocytosis (CSF white blood cell:...
Abstract Background Neurological complications following snake and scorpion bite are diverse. Literature regarding patterns of cerebrovascular injury (CVI) outcomes among these patients is scarce. This a descriptive study the clinical profile, brain imaging findings, mechanisms injury, vascular territory involvement CVI envenomation, in tertiary care center South India. Methodology Patients with sting- envenomation-related were retrospectively enrolled. Neuroimaging was performed on five...
Acute necrotizing encephalopathy after an acute febrile illness, although initially described exclusively in the pediatric age group, has been recently shown to have adult onset as well. In this study, we describe 10 patients (16 years of or older) with encephalopathy. our bilateral thalamic involvement trilaminar pattern diffusion restriction on MR imaging was predominant finding seen all reviewed. Ancillary findings cerebral white matter, brain stem, and cerebellum sparing basal ganglia...
Depression in the elderly is a common and disabling condition. The aim of study was to evaluate sensitivity specificity two-question screen identify depression mental disorders elderly.Residents ward town Vellore were identified by door-to-door survey from which 204 subjects aged over 60 years selected for systematic random sampling. They screened using screen. Revised Clinical Interview Schedule (CIS-R) employed confirm diagnosis.The prevalence disorder, CIS-R standard, found be 31.5%. has...
Introduction Infection with Burkholderia pseudomallei, a gram-negative bacterium found in soil and surface water, is termed melioidosis commonly reported to occur Southeast Asia Northern Australia, where it endemic. It being increasingly India, transmission occurs through inhalation, inoculation, ingestion. The neuroparenchyma, the adjacent soft tissue, bone are known be affected both acute chronic disease forms. Involvement of these structures rare but causes significant mortality...
A 12-year-old boy presented with painless, slowly progressive swelling over the dorsum of penis, evolving 6 years. The was present just underneath penile skin. It mildly compressible without any signs inflammation. There were no other systemic symptoms. only remarkable history circumcision 9 years prior. patient referred for ultrasound and Doppler evaluation suspicion a vascular malformation. Ultrasound scan revealed well-defined lesion beneath dermis, fine internal echoes within it. No...
Background: Primary intracranial germ cell tumors (ICGCT) are often diagnosed with tumor markers and imaging, which may avoid the need for a biopsy. An mild elevation of is seldom stratified as distinct entity. Methods: Fifty-nine patients were into three groups: pure germinoma (PG), secreting (SG) non-germinomatous (NGGCTs). Results: At 5 years, progression-free survival overall groups (PG vs SG NGGCT) 91% versus 81% 59%, 100% 82% 68%, respectively. There was no statistically significant...