Even though intravenous thrombolysis with tissue plasminogen activator (IV tPA) is the standard of care in acute ischemic stroke, its use pregnancy not clearly defined. Mechanical thrombectomy devices can be an option; however, literature on such mechanical stroke lacking. Here we describe two cases that developed embolic during who were successfully treated by clot retrieval using Penumbra system 28 (Penumbra Inc., Alameda, California, USA). To best our knowledge, these are only case...

Antiphospholipid antibody syndrome (APS) may rarely present with isolated thrombocytopenia that be diagnosed and treated as immune thrombocytopenic purpura. A 32-year-old woman was given eltrombopag (a thrombopoietin receptor agonist) to treat presumed She developed catastrophic APS, multiple ischaemic infarcts, microvascular coronary thrombosis digital gangrene. improved after stopping starting immunotherapy (corticosteroids, intravenous immunoglobulin rituximab) but left significant...

An outbreak of acute diarrhoeal disease in a village southern India was investigated through personal interviews all households. Maps were drawn using geographic information system (GIS) tools the water supply system, sewage channels and areas with observed faecal contamination soil within around village. Geographic coordinates for each house extracted from central database healthcare service provider Geographical clustering cases looked SaTScan software, attack rates calculated. Diarrhoeal...

Introduction Robot-assisted rehabilitation has emerged as a promising approach for enhancing motor function in stroke survivors. However, the feasibility and effectiveness of home-based robotic training this population are underexplored, especially low/middle-income countries. Methods This study aimed to address gap by examining independent using PLUTO, device hand training. A total 7 chronic survivors were recruited, with 5 completing study. Results The results revealed high engagement...

Abstract Introduction/Aims In Guillain–Barré syndrome (GBS), the sensitivity and specificity of phrenic compound muscle action potential (CMAP) measurements to predict endotracheal mechanical ventilation are unknown. Hence, we sought estimate specificity. Methods We performed a 10‐year retrospective analysis adult GBS patients from our single‐center laboratory database (2009 2019). The nerve amplitudes latencies before were recorded along with other clinical demographic features. Receiver...

Background Multiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report changes in epidemiology patients with CVT managed over past 26 years. Methods The CMC Vellore registry is a prospectively maintained database at Christian Medical College, since January 1995. Stata software was used to analyse data assess incidence, age...

Neurocysticercosis (NCC), Taenia solium larval infection of the brain, is an important cause acquired seizures in endemic countries, which relate to number, location and degenerating cysts brain. Multicyst infections are common countries although single-cyst prevails India. Single-cyst country suggest a role for host immunity limiting infection. This study examined ex vivo CD4(+) T cells vitro Th1 Th2 cytokine responses T. cyst antigens peripheral blood mononuclear healthy subjects from...

Abstract Objective: Parkinson’s disease (PD) is a neurodegenerative condition that characterized by bradykinesia, rigidity, and gait instability. Inherent to this an increased predisposition falls fractures. Bone health in India has not been studied thus far. This study aimed assess the bone mineral density (BMD), trabecular score (TBS), hip structural analysis (HSA) Indian men with PD compare them matched controls. Methodology: A case-control done at tertiary care center from southern...

Purpose The brainstem plays an important role in the control of micturition, and strokes are known to present with micturition dysfunction. Micturition dysfunction cases lateral medullary infarction (LMI) is uncommon, but often manifests as urinary retention. In this study, we investigated neuro-anatomical correlates retention patients LMI. Methods This was a hospital-based retrospective study conducted neurology unit quaternary-level teaching hospital. Inpatient records from January 2008...

Distal sensory polyneuropathy (DSP) is one of the most common neurological disorders. Although several studies have studied role examination in DSP, there are only limited on utility timed vibration sense (VBS) and joint position (JPS) testing diagnosis DSP.The objective to study VBS JPS at great toe clinical detection DSP.This was prospectively conducted neurology department a tertiary care hospital India. Patients with DSP referred electrophysiology laboratory from August 2017 December...

Acute necrotizing encephalopathy after an acute febrile illness, although initially described exclusively in the pediatric age group, has been recently shown to have adult onset as well. In this study, we describe 10 patients (16 years of or older) with encephalopathy. our bilateral thalamic involvement trilaminar pattern diffusion restriction on MR imaging was predominant finding seen all reviewed. Ancillary findings cerebral white matter, brain stem, and cerebellum sparing basal ganglia...

Guillain-Barre syndrome can be electrophysiologically classified into demyelinating and axonal subtypes nerve conduction studies remain the mainstay in electrodiagnosis. Accurate electrodiagnosis has both therapeutic prognostic significance different criteria sets have been proposed for classification.To classify GBS patients AIDP according to various published (Cornblath, 1990: Hadden, 1998, Rajabally, 2015), investigate if serial NCS changes classification, identify additional parameters...

There is scarce literature regarding the clinical course, comorbidities and long-term outcomes after myasthenic crisis (MC). The natural history of myasthenia gravis (MG) in this subset remains uncertain.The study included a cohort admitted with MC (2007-2017) tertiary care hospital. comorbidities, discharge, prognostic factors were analyzed.Sixty-two patients (89 episodes MC) included. Demographic data was comparable between early- (<50 years) late-onset (≥50 groups. Comorbidities stress...

Background: Solitary Rectal Ulcer Syndrome (SRUS) was a relatively uncommon and easily misdiagnosed clinical entity in children. The diagnosis of this condition often delayed due to lack suspicion. Only case series were available no definitive treatment postulated. Here, we share our experience SRUS institute reviewed the literature published so far. Aim: To study profile response ulcer Children (SRUS). Materials: 1 year follow up diagnosed cases over period 5 years retrospectively collected...

We report a patient who ingested 500 ml of Hexastar 5.5% EC™, hexaconazole-containing product. Clinical toxicity consisted primarily central nervous system depression and generalized trembling. The recovered without sequelae with supportive therapy.

Objectives: Carbamazepine (CBZ) is a commonly used anti-epileptic in rural hospitals India. These lack the facilities to measure CBZ concentration; however, larger this performed using high performance liquid chromatography (HPLC). Dried blood spot (DBS) represents feasible matrix for safe transportation by post/courier. This study was determine whether concentration of serum can be predicted from that measured DBS an inexpensive HPLC method and standard filter paper.Methods: 80 epileptic...

To study the clinical profile and outcomes of patients with paraproteinemic neuropathy (PPN) to explore utility nerve conduction studies (NCSs) differentiate between demyelinating subtypes.We did a retrospective analysis diagnosed PPN January 2010 December 2019 in an inpatient setting. The population consisted above 16 years age presenting features suggestive chronic peripheral on evaluation was found have PPN.A total 74 were identified. predominantly 6th decade, majority males. subtypes...

Acute haemorrhagic leukoencephalitis (AHL) is a fulminant inflammatory disease of cerebral white matter, characterised by demyelination and necrosis. The outcome usually fatal with only few survivors. An unusual presentation 44–year-old South Indian farmer who developed AHL following snake bite reported. Though the initial brain imaging showed extensive involvement matter multiple foci, patient improved spontaneously no specific therapy. A repeat magnetic resonance 28 days after confirmed...

ABSTRACT BACKGROUND AND PURPOSE The brainstem plays a key role in the control of respiration. Strokes involving lateral medulla can rarely produce central hypoventilation syndrome (CHS) characterized by loss automatic respiration called Ondine's curse. In this study, we investigated neuroanatomical correlates CHS patients with medullary infarction (LMI). METHODS Cases following LMI were identified from searching our medical records and literature. Voxel‐based lesion‐symptom mapping lesion...

Limited literature is available on stimulus induced after discharges (SIAD) in patients with peripheral nerve hyperexcitability (PNH). The aim of the study was to examine diagnostic utility SIAD diagnosis and monitoring primary PNH disorders. In this retrospective study, we studied 26 who were admitted a department Neurology from January 2013 April 2019. Their clinical profile, immunological characteristics extracted database conduction studies relooked for presence SIAD. 76% cohort had 90%...