A5051249374- Functional Brain Connectivity Studies
- Infant Development and Preterm Care
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Nutrition, Genetics, and Disease
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Gut microbiota and health
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Infant Nutrition and Health
- Atomic and Subatomic Physics Research
- Eating Disorders and Behaviors
- Radiation Therapy and Dosimetry
- Birth, Development, and Health
- Stress Responses and Cortisol
- Nutrition, Health and Food Behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Biochemical Analysis and Sensing Techniques
- Child Nutrition and Feeding Issues
- COVID-19 Impact on Reproduction
- Breastfeeding Practices and Influences
Rhode Island Hospital
2020-2024
Advanced Imaging Research (United States)
2024
Providence College
2023-2024
Brown University
2022-2024
Hasbro Children's Hospital
2023
Johns Hopkins University
2020
Magnetic resonance imaging (MRI) allows important visualization of the brain and central nervous system anatomy organization. However, unlike electroencephalography (EEG) or functional near infrared spectroscopy, which can be brought to a patient study participant, MRI remains hospital center-based modality. Low magnetic field strength systems, however, offer potential extend beyond these traditional center boundaries. Here we describe development modified cargo van that incorporates...
To characterize cognitive function in young children under 3 years of age over the past decade, and test whether exhibit different development profiles through COVID-19 pandemic. Neurocognitive data (Mullen Scales Early Learning, MSEL) were drawn from 700 healthy neurotypically developing between 2011 to 2021 without reported positive tests or clinical diagnosis SARS-CoV-2 infection. We compared MSEL composite measures (general cognition, verbal, non-verbal development) if those measured...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Magnetic resonance imaging (MRI) has played an increasingly relevant role in understanding infant, child, and adolescent neurodevelopment, providing new insight into developmental patterns neurotypical development, as well those associated with potential psychopathology, learning disorders, other neurological conditions. In addition, studies have shown the impact of a child's physical psychosocial environment on developing brain structure function. A rate-limiting complication these studies,...
Appetitive traits are associated with body weight. Increased understanding of how appetitive evolve from early life could advance research on obesity risk and inform intervention development. We report tracking age-related differences in childhood within the RESONANCE cohort. Parents children aged 6.02 ± 2.99 years completed Child Eating Behavior Questionnaire (CEBQ). Pearson correlations age were tested for all participants contributing at least one observation, using each participant’s...
Emerging evidence implicates gut microbial metabolism in neurodevelopmental disorders, but its influence on typical neurodevelopment has not been explored detail. We investigated the relationship between microbiome and neuroanatomy cognition of 381 healthy children, demonstrating that differences taxa genes are associated with overall cognitive function size brain regions. Using a combination statistical machine learning models, we showed species including Alistipes obesi , Blautia wexlerae...
Observation studies suggest differences in myelination relation to early life nutrition. This two-center randomized controlled trial investigates the effect of a 12-month nutritional intervention on longitudinal changes myelination, cognition, and behavior. Eighty-one full-term, neurotypical infants were into an investigational (N = 42) or control group 39), receiving higher versus lower levels blend nutrients. Non-randomized breastfed 108) served as reference group. Main outcomes (MRI),...
<title>Abstract</title> Myelination is a fundamental process of neurodevelopment that facilitates the efficient brain messaging and connectivity underlies emergence refinement cognitive skills abilities. Healthy maturation myelinated white matter requires appropriate neural activity coordinated delivery key nutritional building blocks, including short long-chain polyunsaturated fatty acids, phospholipids, sphingolipids. While many these nutrients are amply supplied by breastmilk, they often...
Background Food parenting practices are associated with child weight. Such associations may reflect the effects of parents' on children's food intake and However, longitudinal, qualitative, behavioral genetic evidence suggests these could, in some cases, response to risk for obesity, an instance gene–environment correlation. We tested correlations across multiple domains explored role parent-reported appetite relationships. Materials methods Data relevant variables were available N = 197...
The gastrointestinal tract, its resident microorganisms, and the central nervous system are connected by biochemical signaling, also known as "microbiome-gut-brain-axis." Both human brain gut microbiome have critical developmental windows in first years of life, raising possibility that their development is co-occurring likely co-dependent. Emerging evidence implicates microorganisms microbiota composition cognitive outcomes neurodevelopmental disorders (e.g., autism anxiety), but influence...
Abstract Magnetic resonance imaging (MRI) enables unprecedented visualization of brain and central nervous system anatomy, microstructure, function, physiology. However, unlike electroencephalography (EEG) or functional near infrared spectroscopy (fNIRS), which can be used within a doctor’s office, research laboratory, at participant’s home, MRI remains hospital center-based modality. The need for patients participants to travel the scanner limits overall healthcare access potentially biases...
Abstract Three important themes in neuroscience are parcellation, structure-function specificity, and neural plasticity. These relate to: 1. The ability to delineate brain regions, for example on the basis of their cellular composition, myeloarchitecture, microstructural architecture, and/or connectivity profiles; 2. Relate parcellations specific cognitive functions or behaviors; 3. tissue microstructure architecture adaptively change response environmental influences, with concurrent...
Epigenetic processes, including DNA methylation, are emerging as key areas of interest for their potential roles biomarkers and contributors to the risk neurodevelopmental, psychiatric, other brain-based disorders. Despite this growing focus, there remains a notable gap in our understanding how methylation correlates with individual variations brain function structure. Additionally, dynamics these relationships during developmental periods, which critical windows many disorders first appear,...
In this study we sought to (1) Determine the feasibility of collecting remote MRI and cognitive data in adults elderly individuals; (2) Replicate previously reported population-based associations between regional brain volumes performance with an established assessment, PAL. Overall, initial report at-home shows that collection on a portable low-field system at participant's home is possible offers time efficiency, convenience, accessibility participants who might otherwise not be able participate.
ABSTRACT Consumer wearables and health monitors, internet-based cognitive assessments, at-home biosample (e.g., saliva capillary blood) collection kits are increasingly used by public researchers to recruit follow large study populations without requiring intensive in-person visits. In addition reducing participant time travel burden, remote virtual data allows individuals who live long distances from a hospital or university research center, have limited mobility, lack access transportation...
Abstract Consumer wearables and health monitors, internet-based cognitive assessments, at-home biosample (e.g., saliva capillary blood) collection kits are increasingly used by public researchers to recruit follow large study populations without requiring intensive in-person visits. In addition reducing participant time travel burden, remote virtual data allows individuals who live long distances from a hospital or university research center, have limited mobility, lack access transportation...
Within the research context, pediatric magnetic resonance imaging (MRI) has added considerably to our knowledge and understanding of developing brain organization, architectural topology, functional specialization. Clinically, MRI aided identification injury early disease, including leukodystrophies, hydrocephalus, stroke, hemorrhage, encephalopathy amongst numerous others. However, infrastructural needs current state-of-the-art MR systems, scanner cost, space device shielding, power...