A5074636648- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Mobile Health and mHealth Applications
- Neonatal and fetal brain pathology
- Emergency and Acute Care Studies
- Advanced MRI Techniques and Applications
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Protein purification and stability
- Child and Adolescent Health
- Congenital Heart Disease Studies
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Infant Development and Preterm Care
Wellcome Centre for Human Neuroimaging
2024
King's College London
2024
Program for Appropriate Technology in Health
2015-2020
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Pneumonia is the leading infectious cause of death in children worldwide. Each year, pneumonia kills an estimated 935,000 under five years age, with most these deaths occurring developing countries. The current approach for diagnosis low-resource settings—using World Health Organization Integrated Management Childhood Illness (IMCI) paper-based protocols and relying on a health care provider's ability to manually count respiratory rate—has proven inadequate. Furthermore, hypoxemia—a...
Pneumonia is the leading cause of infectious disease mortality in children. Currently, health care providers (HCPs) are trained to use World Health Organization Integrated Management Childhood Illness (IMCI) paper-based protocols and manually assess respiratory rate diagnose pneumonia low-resource settings (LRS). However, this approach relying on clinical signs alone has proven problematic. Hypoxemia, a diagnostic indicator severity associated with an increased risk death, not assessed...
We report a novel formulation approach for development of thermostable oral insulin tablet. Using freeze drying to form heat stable tablet in single-step process, we demonstrate hydroxypropyl beta cyclodextrin (HP-β-CD) encapsulated lipophilic ion-pair complex using bile salt achieves intestinal absorption and sustained glucose levels. The tablets produced this simple with only two excipients offer protection from enzymatic stomach acid degradation facilitate uptake, without any need...
The burden of neurological disorders in low- and middle-income countries (LMICs) may be underestimated due to the limited number diagnostic imaging devices trained specialists operate interpret scans. Recent advancements low-field (<100 milliteslas) magnetic resonance (LFMRI) hold significant promise for improving access pediatric neuroimaging technology's lower costs, portability, reduced infrastructure training requirements. Explore user needs experiences on use a portable LFMRI LMICs. We...
Hypoxemia is a complication of pneumonia—the leading infectious cause death in children worldwide. Treatment generally requires oxygen-enriched air, but access low-resource settings expensive and unreliable. We explored use reservoir cannulas (RCs), which yield oxygen savings adults have not been examined children. Toddler, small child, adolescent breathing profiles were simulated with artificial lung airway models. An concentrator provided flow rates 0 to 5 L/min via standard nasal cannula...
Abstract Background Pneumonia and possible serious bacterial infection (PSBI) are leading causes of death among under-five children. The World Health Organization (WHO) issued global recommendations for the case management childhood pneumonia PSBI when referral is not feasible with oral amoxicillin. However, few governments to date have incorporated child-friendly amoxicillin dispersible tablets (DT) into their national treatment guidelines policies. We aimed understand key drivers...
Continuous oxygen treatment is essential for managing children with hypoxemia, but access to in low-resource countries remains problematic. Given the high burden of pneumonia these and fact that flow can be gradually reduced as therapy progresses, conservation through routine titration warrants exploration.To determine amount saved via during hypoxemic pneumonia.Based on published clinical data, we developed a model rates needed manage assuming recommended rate at start therapy, comparing...