A5027994498- Antioxidant Activity and Oxidative Stress
- Retinal Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Nutrition and Health in Aging
- Stroke Rehabilitation and Recovery
- Healthcare Policy and Management
- Frailty in Older Adults
- Quality and Supply Management
- Retinal and Optic Conditions
- Assembly Line Balancing Optimization
- Retinal Development and Disorders
- Tea Polyphenols and Effects
- Quality and Safety in Healthcare
- Metabolomics and Mass Spectrometry Studies
- Health Systems, Economic Evaluations, Quality of Life
- Biochemical effects in animals
- Fatty Acid Research and Health
- Big Data and Business Intelligence
- Balance, Gait, and Falls Prevention
- Musculoskeletal pain and rehabilitation
- Neonatal and fetal brain pathology
- Quality and Management Systems
- Health and Lifestyle Studies
University of Limerick
2023-2025
University of Stavanger
2024
Waterford Institute of Technology
2014-2021
University of Southampton
2015
Loyola University Chicago
2008
Purpose: The high-performance visual function associated with central vision is mediated by the macula (the retina), which accumulates three diet-derived pigments carotenoids lutein [L], zeaxanthin [Z], and meso-zeaxanthin [MZ]). Our study sought to investigate impact on function, including contrast sensitivity (CS), of supplementation these naturally occurring carotenoids, in individuals low retinal concentrations. Methods: Subjects consumed daily a formulation containing 10 mg L, 2 Z, MZ...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Background: The macula (central retina) contains a yellow pigment, comprising the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin, known as macular pigment (MP). concentrations of MP's constituent in retina bra
Patients with Alzheimer's disease (AD) exhibit significantly less macular pigment (MP) and poorer vision when compared to control subjects.To investigate supplementation the carotenoids on MP, vision, cognitive function in patients AD versus controls.A randomized, double-blind clinical trial placebo active arms. 31 age-similar subjects were supplemented for six months either Macushield (10 mg meso-zeaxanthin [MZ]; 10 lutein [L]; 2 zeaxanthin [Z]) or (sunflower oil). MP was measured using...
A growing body of scientific evidence suggests that enrichment certain nutritional compounds in the brain may reduce risk Alzheimer's disease (AD).To investigate impact supplemental xanthophyll carotenoids plus omega-3 fatty acids on progression patients with AD.Three trial experiments were performed. In Trials 1 and 2 (performed AD over an 18-month period), 12 (AD status at baseline: 4 mild 8 moderate) supplemented a carotenoid only formulation (Formulation 1;...
To compare the impact of sustained supplementation using different macular carotenoid formulations on pigment (MP) and visual function in early age-related degeneration (AMD). Sixty-seven subjects with AMD were randomly assigned to: Group 1 (20 mg per day lutein (L), 0.86 zeaxanthin (Z); Ultra Lutein), 2 (10 meso-zeaxanthin (MZ), 10 L, Z; Macushield; Macuhealth), 3 (17 MZ, Z). MP was measured customised heterochromatic flicker photometry assessed by measuring contrast sensitivity (CS)...
Background: There is a biologically plausible rationale whereby the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), which are collectively referred to as macular pigment (MP) in central retina (macula), support maintenance of cognition via their antioxidant anti-inflammatory properties. Objective: To investigate impact supplemental L, Z, MZ on memory, executive function, verbal fluency among healthy individuals with low MP levels. Methods: In this double-blind,...
Background: Macular pigment (MP) levels correlate with brain concentrations of lutein (L) and zeaxanthin (Z), have also been shown to cognitive performance in the young elderly.Objective: To investigate relationship between MP, serum L Z, function subjects free retinal disease low MP (Group 1, n = 105) AMD 2, 121).Methods: was measured using customized heterochromatic flicker photometry dual-wavelength autofluorescence; assessed a battery validated cognition tests; Z were determined by...
Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health older adults. However, equivocal results from smaller studies clinical trials highlight need for large population-based with comprehensive measures function adjustment multiple confounders to examine such associations more depth.In current study, we investigated association between domain-specific performance 4,076 community-dwelling adults aged 50...
Purpose This research aims to enhance digital marketing processes by using design of experiments in safelist mailers and traffic exchange websites. Design/methodology/approach The applies improve an online website. Findings findings show that can help quality generating more interactions with websites, reducing time spent the process, allocating appropriate amount credits significant websites avoiding product price increases. Research limitations/implications increase awareness impact...
Alzheimer's disease (AD) is a progressive, neurodegenerative disease, characterised by decline of memory, cognitive function and changes in behaviour. Generic markers lipid peroxidation are increased AD reactive oxygen species have been suggested to be involved the aetiology decline. Carotenoids depleted serum, therefore we compared serum oxidation between age-matched control subjects before after carotenoid supplementation. The novel oxidised phospholipid biomarker...
Trunk control is impaired after stroke but little known about how changes in posture relate to other deficits. We examined spinal postural alignment people with chronic and explored the relationship between clinical measures.Twenty-one subjects 22 age-matched healthy comparison participated this observational, cross-sectional study. Data collection included measurements of thoracic, lumbar, sacral, overall sagittal plane both sitting standing. Measurements were made different postures,...
<h3>Background</h3> Age-related macular degeneration (AMD) remains the most common cause of visual loss among subjects over 50 years age in developed world. The Irish Longitudinal study on Ageing (TILDA) is a population-based aged or older, designed to investigate factors that influence ageing, and has enabled this investigation prevalence AMD Republic Ireland (ROI). <h3>Methods</h3> Data collected from nationally representative sample community-living older adults ROI period November 2009...
Purpose: It is essential to have an appropriate measure assess macular pigment (MP) that can provide accurate, valid, and reliable representation of the MP within macula. The aim this study was describe introduce optical volume (MPOV) as optimal value for reporting MP. Methods: Three hundred ninety-three subjects were analyzed using Heidelberg Spectralis with investigational density (MPOD) module MPOV MPOD at four foveal eccentricities (0.23°, 0.51°, 0.98°, 1.76° [7° reference point])....
The xanthophyll carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) are found at the macula, central part of retina, where they referred to as macular pigment (MP). MP is studied in human subjects because its proven role enhancing visual function putative protecting against age-related degeneration. These benefits probably due antioxidant short-wavelength filtering properties MP. It known that eggs a dietary source L Z. This experiment was designed measure egg yolk carotenoid...
Purpose: To investigate the effect of cataract (and surgery) on macular pigment (MP) measurements using Heidelberg Spectralis HRA+OCT MultiColor device. Methods: Thirty-six patients (age, 54–87 years) scheduled for surgery at Institute Eye Surgery, Ireland, were enrolled in this study. Cataracts graded Lens Opacities Classification System (LOCS) III, and was performed standard phacoemulsification technique with implantation a Tecnis ZCB00 or ZCT intraocular lens. Macular measured before...
Abstract The macular carotenoids lutein (L), zeaxanthin (Z) and meso -zeaxanthin (MZ) accumulate at the macula, where they are collectively referred to as pigment (MP). Augmentation of this pigment, typically achieved through diet supplementation, enhances visual function protects against progression age-related degeneration. However, it is known that eggs a rich dietary source L Z, in highly bioavailable matrix. In single-blind placebo-controlled study, L- MZ-enriched control non-enriched...
To investigate non-dietary correlates and determinants of plasma lutein (L) zeaxanthin (Z) concentrations in The Irish Longitudinal Study on Ageing (TILDA) sample. Community dwelling adults the Republic Ireland (ROI). Participants: 3,681 participants aged 50 years older. TILDA is a nationally representative prospective cohort study community over ROI. Demographic health variables were collected during face-to-face interview carried out home (n=8175), substantial proportion these (n=5035;...
Purpose: Although recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation. Methods: This cross-sectional study included 85 patients and 22 controls. All subjects had standard automated perimetry (SAP) retinal nerve fiber layer (RNFL) thickness measurements. Intake of lutein (L) zeaxanthin (Z) was estimated using a novel dietary screener. The Heidelberg Spectralis dual-wavelength autofluorescence (AF)...
Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research commercial interest for their applications in human health. Research into formulations to enhance bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared different free L, Z, MZ sunflower or omega-3 oil versus diacetates (Ld, Zd, MZd) a micromicellar formulation. Fasting serum carotenoids, macular pigment, skin carotenoid score were analysed at...
Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed self-reported prevalence of age-related macular degeneration (AMD).Material methods: Data collected from a nationally representative prospective cohort study community-dwelling adults aged 50 years over in the Republic Ireland. Participants underwent computer-assisted personal interview center-based health assessment. Plasma L total Z (Z meso-zeaxanthin [MZ]) were measured by high performance...
The carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin deposit at the macula as macular pigment (MP) provide visual benefits protection against diseases. present study investigated MP, its nutritional environmental determinants, constituent in serum from a Mexican sample, healthy participants with metabolic Additionally, we compared these variables an Irish sample.