A5062169058- Retinal Diseases and Treatments
- Antioxidant Activity and Oxidative Stress
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinoids in leukemia and cellular processes
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Visual perception and processing mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Ocular and Foreign Body Injuries
- Biosensors and Analytical Detection
- Retinal Development and Disorders
- Optical Imaging and Spectroscopy Techniques
- Identification and Quantification in Food
- Ophthalmology and Eye Disorders
- Salmonella and Campylobacter epidemiology
- Ocular Surface and Contact Lens
- Facial Trauma and Fracture Management
- Cerebral Venous Sinus Thrombosis
- Ocular Oncology and Treatments
- Biochemical effects in animals
Central Michigan University
2024
University of Florida
2024
Utah Valley University
2019
Waterford Institute of Technology
2010-2019
University Hospital Waterford
2003-2017
Queen Mary University of London
2013
Waterford Institute
2008-2012
Kentucky Department for Public Health
2011
Royal Victoria Eye and Ear Hospital
2009
Queen's University Belfast
2008
<h3>Background/aims</h3> Real-life anti-vascular endothelial growth factor (VEGF) therapy use in patients with wet age-related macular degeneration (wAMD) was assessed a retrospective, observational study Canada, France, Germany, Ireland, Italy, the Netherlands, UK and Venezuela. <h3>Methods</h3> Medical records of wAMD, who started ranibizumab treatment between 1 January 2009 31 August 2009, were evaluated. Data collected until end and/or monitoring or 2011. <h3>Results</h3> 2227 received...
<h3>Background/aims</h3> To identify predictive markers for the outcomes of anti-vascular endothelial growth factor therapy neovascular age-related macular degeneration (nAMD). <h3>Methods</h3> AURA was a retrospective, observational, multicentre study that monitored 2-year following intravitreal ranibizumab treatment in patients with nAMD. Using stepwise regression analysis, we evaluated association between visual acuity outcomes, baseline characteristics and resource utilisation order to...
Purpose: The high-performance visual function associated with central vision is mediated by the macula (the retina), which accumulates three diet-derived pigments carotenoids lutein [L], zeaxanthin [Z], and meso-zeaxanthin [MZ]). Our study sought to investigate impact on function, including contrast sensitivity (CS), of supplementation these naturally occurring carotenoids, in individuals low retinal concentrations. Methods: Subjects consumed daily a formulation containing 10 mg L, 2 Z, MZ...
To assess the risk factors for endothelial cell loss after phacoemulsification cataract surgery performed by a junior resident.Ophthalmic teaching hospital, Dublin, Ireland.This prospective study included 40 eyes having divide-and-conquer resident under supervision of an experienced surgeon. Nine variables were examined to corneal postoperatively.The mean overall was 11.6%. Longer time, longer absolute and effective phaco higher ultrasound power, density significantly associated with on...
Background: The macula (central retina) contains a yellow pigment, comprising the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin, known as macular pigment (MP). concentrations of MP's constituent in retina bra
Purpose: At the macula, carotenoids meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z) are collectively referred to as macular pigment (MP). This study was designed measure serum responses a carotenoid formulation.Materials Methods: Ten subjects were recruited into this (five normal five with early age-related degeneration [AMD]). Subjects instructed consume formulation containing 7.3 mg of MZ, 3.7 L, 0.8 Z everyday over an eight-week period. The spatial profile MP optical density (i.e.,...
Patients with Alzheimer's disease (AD) exhibit significantly less macular pigment (MP) and poorer vision when compared to control subjects.To investigate supplementation the carotenoids on MP, vision, cognitive function in patients AD versus controls.A randomized, double-blind clinical trial placebo active arms. 31 age-similar subjects were supplemented for six months either Macushield (10 mg meso-zeaxanthin [MZ]; 10 lutein [L]; 2 zeaxanthin [Z]) or (sunflower oil). MP was measured using...
To compare the impact of sustained supplementation using different macular carotenoid formulations on pigment (MP) and visual function in early age-related degeneration (AMD). Sixty-seven subjects with AMD were randomly assigned to: Group 1 (20 mg per day lutein (L), 0.86 zeaxanthin (Z); Ultra Lutein), 2 (10 meso-zeaxanthin (MZ), 10 L, Z; Macushield; Macuhealth), 3 (17 MZ, Z). MP was measured customised heterochromatic flicker photometry assessed by measuring contrast sensitivity (CS)...
Background: There is a biologically plausible rationale whereby the dietary carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), which are collectively referred to as macular pigment (MP) in central retina (macula), support maintenance of cognition via their antioxidant anti-inflammatory properties. Objective: To investigate impact supplemental L, Z, MZ on memory, executive function, verbal fluency among healthy individuals with low MP levels. Methods: In this double-blind,...
To investigate the relationship between percentage of body fat and macular pigment (MP) optical density.One hundred healthy subjects ages 22 60 years volunteered to participate in this study. MP density was measured psychophysically, serum lutein zeaxanthin were quantified by HPLC, dietary intake assessed using a validated food frequency questionnaire. Body dual energy x-ray absorptiometry (DEXA); mass index (BMI) also calculated for each subject. Clinical personal details recorded, with...
Macular pigment (MP) is composed of two dietary carotenoids, lutein and zeaxanthin, a carotenoid generated by the retina, meso-zeaxanthin. There large intersubject variability in peak optical density, spatial profile, lateral extent macular pigment, it has been suggested that foveal architecture may play role this variability. This study an initial investigation relationship between profile architecture.Sixty normal subjects were enrolled (one was eventually excluded). The density (MPOD)...