A5090857831- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Substance Exposure Effects
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Grief, Bereavement, and Mental Health
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Maternal and Perinatal Health Interventions
- Global Maternal and Child Health
- Prenatal Screening and Diagnostics
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Smoking Behavior and Cessation
- Folate and B Vitamins Research
- Preterm Birth and Chorioamnionitis
- Congenital Heart Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Autopsy Techniques and Outcomes
- Migration, Health and Trauma
- Homelessness and Social Issues
Stellenbosch University
2016-2025
University of Stavanger
2024
Western Cape Department of Health
2010-2023
Microsoft (Brazil)
2019
Infusion (South Africa)
2019
Boston Children's Hospital
2010-2016
Harvard University
2010-2016
Brigham and Women's Hospital
2016
National Health Laboratory Service
2016
University of North Dakota
2016
Abstract Background The S afe P assage tudy is a large, prospective, multidisciplinary study designed to (1) investigate the association between prenatal alcohol exposure, sudden infant death syndrome (SIDS), and stillbirth, (2) determine biological basis of spectrum phenotypic outcomes from as modified by environmental genetic factors that increase risk SIDS , in surviving children, fetal disorders. Methods results provided are based on an interim assessment 6004 women enrolled, out 12 000...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Aims The objective of this study is to illustrate the application a machine learning algorithm, K Nearest Neighbor ( k-NN ) impute missing alcohol data in prospective among pregnant women. Methods We used from Safe Passage (n = 11,083). Daily consumption for last reported drinking day and 30 days prior was recorded using Timeline Follow back method, which generated variable amount per participants. Of 3.2 million person-days observation, were 0.36 (11.4%). Using imputed values weighted...
We investigated agreement between self-reported prenatal alcohol exposure (PAE) and objective meconium markers to determine the optimal marker threshold for identifying PAE.Meconium fatty acid ethyl esters (FAEE), glucuronide (EtG), sulfate (EtS) were quantified by LC-MS/MS in 0.1 g from infants of Safe Passage Study participants. Detailed PAE information was collected women with a validated timeline follow-back interview. Because formation begins during weeks 12-20, maternal drinking at or...
Sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality. Although rate has plateaued, any unexpected an a family tragedy thus finding causes and contributors to risk remains major public health concern. The primary objective this investigation was determine patterns drinking smoking during pregnancy that increase SIDS.The Safe Passage Study prospective, multi-center, observational study with 10,088 women, 11,892 pregnancies, 12,029 fetuses, followed 1-year post...
Approximately 7% of preterm infants receive an autism spectrum disorder (ASD) diagnosis. Yet, there is a significant gap in the literature identifying prospective markers neurodevelopmental risk infants. The present study examined two electroencephalography (EEG) parameters during infancy, absolute EEG power and aperiodic activity spectral density (PSD) slope, association with subsequent cognitive ability diverse cohort children born South Africa. Participants were 71 between 25 36 weeks...
Objective To evaluate the perinatal outcome of expectant management early onset, severe pre‐eclampsia. Design Prospective case series extending over a five‐year period. Setting Tertiary referral centre. Population All women ( n = 340 ) presenting with pre‐eclampsia, where both mother and fetus were otherwise stable. Methods Frequent clinical biochemical monitoring maternal status careful blood pressure control. Fetal surveillance included six‐hourly heart rate monitoring, weekly Doppler...
Objective To evaluate the safety and outcome of women undergoing expectant management early onset, severe pre‐eclampsia. Design Prospective case series extending over a five‐year period. Setting Tygerberg Hospital, tertiary referral centre. Population All ( n = 340 ) presenting with pre‐eclampsia, where both mother fetus were otherwise stable. Methods Frequent clinical biochemical monitoring maternal status, together careful blood pressure control, in high care obstetric ward. Main measures...
: media-1vid110.1542/5741323271001PEDS-VA_2017-3651Video Abstract BACKGROUND: The loss of a child is associated with elevated grief severity, and sudden infant death syndrome (SIDS) the leading cause postneonatal mortality in United States. diagnosis prolonged disorder (PGD) has gained broader acceptance use. Little known about PGD mothers after SIDS.Between May 2013 July 2016, we assessed 49 SIDS-bereaved living informal settlements near Cape Town, South Africa, on Pine Ridge Indian...
<h3>Importance</h3> Prenatal smoking is a known modifiable risk factor for stillbirth; however, the contribution of prenatal drinking or combination and uncertain. <h3>Objective</h3> To examine whether exposure to alcohol tobacco cigarettes associated with stillbirth. <h3>Design, Setting, Participants</h3> The Safe Passage Study was longitudinal, prospective cohort study data collection conducted between August 1, 2007, January 31, 2015. Pregnant women from Cape Town, South Africa, Northern...
ABSTRACT Toddler visual attention development correlates with subsequent language, cognitive, and social developmental outcomes. This study investigates the association of maternal trauma on toddler looking behaviors in 39 mother‐child dyads from Western Cape Province, South Africa. At 15 months postpartum, was assessed using Life Events Checklist multisensory skills were measured Multisensory Attention Assessment Protocol (MAAP) during eye‐tracking. We used two‐way mixed ANOVA to analyze...
Abstract Background Prenatal alcohol exposure (PAE) is a worldwide public health concern. While PAE known to be associated with low birth weight, little about timing and quantity of on fetal growth. This study investigated the association between periconceptional prenatal longitudinal growth, focusing in high cohort. Methods The Safe Passage Study was prospective cohort study, including 1698 pregnant women. Two-dimensional transabdominal ultrasound examinations were performed measure femur...
ABSTRACT Objective To determine whether knowledge of the result Doppler velocimetry umbilical artery is beneficial to management a high risk pregnancy. Design Randomised controlled trial. The trial was type, designed assess benefit accruing from additional information supplied by velocimetry. Setting Tygerberg Hospital, Cape Town, South Africa. hospital serves population lower socio‐economic groups. Subject Women with pregnancies 28 or more weeks gestation hypertensive diseases and/or...
<h3>Importance</h3> Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is noninvasive measure cortical function that previously been used examine effects in utero exposures and associations with neurodevelopment. <h3>Objective</h3> To the association prenatal exposure (PAE) smoking (PTE) brain activity newborns. <h3>Design, Setting, Participants</h3> This prospective cohort study enrolled mother-newborn dyads from...
Significance Genomic imprinting is essential for human development and occurs in germ cells before fertilization. The noncoding RNA, nc886 , the only known example of more than 100 such genes which shows variable frequencies maternal imprinting. Here, we show that DNA methylation imprint present oocytes probability increases as a function age. Importantly, demonstrate alcohol consumption but not cigarette smoking associated with lower frequency While most studies focus on postconceptional...