A5011337246- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal and fetal brain pathology
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- Reproductive System and Pregnancy
- Nutritional Studies and Diet
- Osteoarthritis Treatment and Mechanisms
- Maternal and fetal healthcare
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Asthma and respiratory diseases
- Mobile Health and mHealth Applications
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Musculoskeletal pain and rehabilitation
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
Erasmus MC - Sophia Children’s Hospital
2011-2023
Maastricht University Medical Centre
2022
Erasmus MC Cancer Institute
2016-2022
University Medical Center Utrecht
2022
Isala
2022
Community Link
2022
Albert Schweitzer Ziekenhuis
2017-2019
Emma Kinderziekenhuis
2011
Rationale: It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome.Objectives: To assess the effect of and resuscitation directed at decreasing intensive care unit (ICU) admitted with a level greater than or equal 3.0 mEq/L.Methods: Patients were randomly allocated two groups. In group, was guided by objective 20% more per 2 hours for 8 ICU stay. control team had no knowledge (except admission value) this period....
Abstract Objective According to common knowledge and retrospective studies, approximately 75–90% of patients with rheumatoid arthritis (RA) will improve during pregnancy. Prospective data on disease activity pregnancy are limited. Therefore, this study aimed prospectively determine the in RA treated an era new treatment options. Methods For 84 (American College Rheumatology criteria), a Disease Activity Score 28 joints (DAS28) medication use were obtained, before conception if possible, at...
Abstract Objective To determine the outcome of pregnancy in women with rheumatoid arthritis (RA) relation to disease activity and medication use during pregnancy. Methods In a prospective study, pregnant RA were evaluated before conception (when possible), each trimester pregnancy, postpartum. Clinical characteristics, activity, use, analyzed. examine independent influence prednisone on birth weight, regression analyses performed, adjustments for gestational age child at delivery, sex...
Abstract Background The association between body composition (e.g. sarcopenia or visceral obesity) and treatment outcomes, such as survival, using single‐slice computed tomography (CT)‐based measurements has recently been studied in various patient groups. These studies have conducted with different software programmes, each their specific characteristics, of which the inter‐observer, intra‐observer, inter‐software correlation are unknown. Therefore, a comparative study was performed....
Abstract Introduction Improvement of rheumatoid arthritis (RA) during pregnancy has been causatively associated with increased galactosylation immunoglobulin G (IgG) N-glycans. Since previous studies were small, did not include the postpartum flare and study sialylation, these issues addressed in present study. Methods Serum from 148 RA cases 32 healthy controls was collected at several time points before, after pregnancy. determined according to European League Against Rheumatism (EULAR)...
Psychoanalytically oriented day hospital therapy, later manualized and named mentalization-based treatment (MBT), has proven to be a (cost-) effective for patients with severe borderline personality disorder high degree of psychiatric comorbidity (BPD) in the United Kingdom (UK). As yet it not been shown whether MBT would yield similar results when conducted by an independent institute outside UK. We investigated applicability outcome 18-month, Netherlands means prospective cohort study 45...
Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth.We prospectively evaluated the associations of maternal air with growth characteristics and adverse birth outcomes in 7,772 subjects Netherlands.Particulate matter an aerodynamic diameter < 10 μm (PM10) nitrogen dioxide (NO2) levels were estimated using dispersion modeling at home address. Fetal head circumference, length, weight each trimester by ultrasound. Information was obtained from medical...
<b>Objective</b> To assess the effectiveness of supervised exercise therapy compared with usual care respect to recovery, pain, and function in patients patellofemoral pain syndrome. <b>Design</b> Open label randomised controlled trial. <b>Setting</b> General practice sport physician practice. <b>Participants</b> Patients a new episode syndrome recruited by their general practitioner or physician. <b>Interventions</b> The intervention group received standardised programme for 6 weeks...
Rheumatoid arthritis (RA) is known to improve during pregnancy and flare after delivery. Changes in the glycosylation of immunoglobulin G (IgG)'s fragment crystallizable (Fc) have been suggested play a role herein. Recent animal studies indicate that not galactosylation but mainly sialylation important this respect. We aim find new associations between IgG-Fc N-glycosylation improvement RA Sera patients (n = 251 pregnancies) healthy controls 32), all participating prospective cohort study on...
<b>PURPOSE</b> We undertook a study to evaluate the effectiveness of corticosteroid injections in primary care patients with greater trochanteric pain syndrome (GTPS). <b>METHODS</b> evaluated effect compared expectant treatment (usual care) pragmatic, multicenter, open-label, randomized clinical trial Netherlands. Patients (aged 18 80 years) GTPS visiting 81 participating physicians were randomly allocated receive either local (n = 60) or usual 60). Primary outcomes severity (numerical...
Poor nutrition and lifestyle behaviors exert detrimental effects on reproduction health during the life course. Therefore, interventions periconceptional period can improve fertility, pregnancy outcome, of subsequent generations.This survey investigates compliance, usability, initial effectiveness Web-based mHealth platform, Smarter Pregnancy.A free subscription to Pregnancy, was provided couples contemplating (n=1275) or already pregnant (n=603). After baseline identification inadequate...
To evaluate the effectiveness of Tai Chi Chuan in fall prevention elderly people living at home with a high risk falling.Randomized controlled trial.Two industrial towns western part Netherlands.Two hundred sixty-nine (average age 77) falling.The intervention group received training for 1 hour twice week 13 weeks; control usual care. Both groups brochure containing general information on how to prevent incidents.Primary outcome was number falls over 12 months. Secondary outcomes were...
Background: The effectiveness of glucosamine sulfate as a symptom and disease modifier for osteoarthritis is still under debate. Objective: To assess whether has an effect on the symptoms structural progression hip during 2 years treatment. Design: Randomized, controlled trial. Setting: Primary care in Netherlands. Patients: 222 patients with who were recruited by their general practitioner. Patients eligible if they met American College Rheumatology clinical criteria osteoarthritis....
Our aim was to study the prevalence and characteristics of constipation in children with profound multiple disabilities, as data this area are scarce.A cross-sectional observational performed specialized day-care centres schools Netherlands. The included 152 (81 males, 71 females; mean age 9 y 6 mo, SD 4 mo). Intellectual disability ranged from moderate (7%) (52%) all participants who also had severe motor disabilities (83% classified at Gross Motor Function Classification System level V)....
Blood pressure tracking can be used to examine the predictability of future values by early measurements. In a population-based prospective cohort study, among 8482 pregnant women, we examined whether blood in pregnancy tracks third trimester and this is influenced maternal characteristics associated with risk gestational hypertensive disorders.Blood was measured each pregnancy. Information about doctor-diagnosed pregnancy-induced hypertension preeclampsia obtained from medical records....
Grip strength dynamometers often are used to assess hand function in children. The use of normative grip data at followup is difficult because the influence growth and neuromuscular maturation. As an alternative, infant welfare centers throughout world diagrams observe growth. aim this study was develop similar for We measured strength, dominance, gender, height, weight 225 children, 4 12 years old. developed separate statistical models both hands boys girls drawing curves. increased with...
den Bakker M A, Willemsen S, Grünberg K, Noorduijn L van Oosterhout F M, Suylen R J, Timens W, Vrugt B, Wiersma‐van Tilburg A & Thunnissen B J (2010) Histopathology 56, 356–363 Small cell carcinoma of the lung and large neuroendocrine interobserver variability Aims: To test hypothesis that published morphological criteria permit reliable segregation small (SCLC) (LCNEC) cases by determining variation. Methods results: One hundred seventy SCLC, LCNEC diagnosed as before had been...
The aim of our study was to examine the associations breastfeeding duration and exclusiveness with risks asthma-related symptoms in preschool children, explore whether these are explained by atopic or infectious mechanisms. This embedded a population-based prospective cohort 5,368 children. Information on duration, symptoms, including wheezing, shortness breath, dry cough persistent phlegm, obtained questionnaires. Compared children who were breastfed for 6 months, those never had overall...
How do human embryonic growth trajectories evolve in the first trimester, and is first-trimester associated with fetal birthweight (BW)? Human rates increase between 9 10 weeks of gestation are mid-pregnancy BW. Fetal health disease risks later life. Until recently, prenatal care research have been focused predominantly on second third trimesters pregnancy. Longitudinal data remain scarce. We recruited 201 pregnancies before 8 a prospective periconception cohort study conducted tertiary...
Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers offspring during the life course. While severe early-onset PE (EOPE) phenotype originates from impaired placentation early pregnancy, late-onset (LOPE) is particular associated with pre-existing maternal risk factors. We hypothesize that altered epigenetic programming placental fetal tissues these changes might elucidate disease susceptibility offspring.A nested case-control study was conducted The...
Unhealthy nutrition contributes to the worldwide rising prevalence of noncommunicable diseases. As most adverse reproductive outcomes originate during periconception period, effective interventions targeting this period are needed. Therefore, we developed lifestyle intervention Smarter Pregnancy empower women adapt a healthy diet prior conception and early pregnancy performed randomized controlled trial.The objectives trial were investigate compliance effectiveness in using program.Women...