A5109103357- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Genomic variations and chromosomal abnormalities
- Cerebrospinal fluid and hydrocephalus
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Congenital heart defects research
- Grief, Bereavement, and Mental Health
- Wound Healing and Treatments
- Esophageal and GI Pathology
- Ethics and Legal Issues in Pediatric Healthcare
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Neonatal and fetal brain pathology
- Tracheal and airway disorders
- Gestational Diabetes Research and Management
- Electrospun Nanofibers in Biomedical Applications
Erasmus MC
2016-2025
Erasmus University Rotterdam
2012-2023
Erasmus MC - Sophia Children’s Hospital
2017-2023
Radboud University Nijmegen
2008-2016
Radboud University Medical Center
2008-2016
Blood plasma of pregnant women contains circulating cell-free fetal DNA (ccffDNA), originating from the placenta. The use this for non-invasive detection aneuploidies using massively parallel sequencing (MPS)-by-synthesis has been proven previously. Sequence performance may, however, depend on MPS platform and therefore we have explored possibility multiplex MPS-by-ligation, Applied Biosystems SOLiD(™) 4 system. isolated samples 52 women, carrying normal or aneuploid fetuses, was sequenced...
In Brief OBJECTIVE: To study perinatal mortality and neonatal morbidity in a large cohort of monoamniotic twin pregnancies with special emphasis to the gestational age-specific mortality. METHODS: The included delivered 10 centers Netherlands between January 2000 December 2007. RESULTS: A total 98 were included. rate (20 weeks gestation through 28 days life) was 19%; after exclusion fetuses lethal anomalies, 17%. After 32 gestation, only two complicated by (4%). incidence twin–twin...
Offspring exposed to preeclampsia (PE) show an increased risk of cardiovascular disease in adulthood. We hypothesize that this is mediated by a disturbed vascular development the placenta, umbilical cord and fetus. Therefore, we investigated associations between early-onset PE (EOPE), late-onset (LOPE) features placental newborn health.We performed nested case-control study The Rotterdam Periconceptional Cohort, including 30 pregnancies (15 EOPE, 15 LOPE) 218 control (164 uncomplicated...
Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers offspring during the life course. While severe early-onset PE (EOPE) phenotype originates from impaired placentation early pregnancy, late-onset (LOPE) is particular associated with pre-existing maternal risk factors. We hypothesize that altered epigenetic programming placental fetal tissues these changes might elucidate disease susceptibility offspring.A nested case-control study was conducted The...
To assess the predictive value of observed-to-expected lung-to-head ratio (O/E LHR) for survival and chronic lung disease (CLD) in survivors left-sided congenital diaphragmatic hernia (CDH) an era standardized neonatal treatment, to evaluate O/E LHR trajectory survival. This retrospective cohort study was performed two high-volume CDH centers Netherlands prenatally detected, isolated patients born between 2008 2014. liver position were determined using 2D-ultrasonography at three time points...
Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS should not only address technical issues, but also consider socio-ethical legal aspects, its application area, corresponding design implications. This paper represents consensus opinion group healthcare professionals, designers, ethicists, researchers patient representatives, who have expertise tertiary obstetric neonatal care,...
Monochorionic (MC) twins are at increased risk for perinatal mortality and serious morbidity due to the presence of placental vascular anastomoses. Cerebral injury can be secondary haemodynamic hematological disorders during pregnancy (especially twin-to-twin transfusion syndrome (TTTS) or intrauterine co-twin death) from postnatal associated with prematurity low birth weight, common complications in twin pregnancies. We investigated neurodevelopmental outcome MC dichorionic (DC) age two...
Interstitial deletions of the chromosome 22q11.2 region are most common microdeletions in humans. The TBX1 gene is considered to be major candidate for main features deletion syndrome, including congenital heart malformations, (para)thyroid hypoplasia, and craniofacial abnormalities. We report on eight patients with atypical 22q11.2. These comprise distal part deleted but do not encompass gene. Ten similar overlapping have been reported previously. clinical these described compared those...
ABSTRACT Objective We evaluated both clinical and laboratory aspects of our new strategy offering quantitative fluorescence (QF)‐PCR followed by non‐targeted whole genome 250K single‐nucleotide polymorphism array analysis instead routine karyotyping for prenatal diagnosis fetuses with structural anomalies. Methods Upon the detection fetal anomalies, parents were offered a choice between QF‐PCR (QF/array) or (QF/karyo). Results Two hundred twenty samples included. In 153/220 cases (70%),...
OBJECTIVE Myelomeningocele (MMC) is the most common form of spina bifida, with a lifelong impact on quality life for infants born this condition. In recent decades, fetal surgery has evolved from an experimental therapy to standard care many centers in world. study, authors aimed provide overview current management and outcomes MMC managed at their institution. This then provides center-specific historical cohort comparison future antenatal-treated cases. METHODS retrospective,...
Tissue engineering may become an alternative to current bladder augmentation techniques. Large scaffolds are needed for clinically significant augmentation, but can result in fibrosis and graft shrinkage. The purpose of this study was investigate whether smart acellular collagen-heparin with growth factors (GFs) VEGF, FGF2, HB-EGF enhance tissue regeneration capacity a large animal model diseased bladder. Scaffolds bovine type I collagen heparin measuring 3.2 cm diameter were prepared. In 23...
Abstract Introduction In clinical practice, fetal heart rate monitoring is performed intermittently using Doppler ultrasound, typically for 30 minutes. case of a non‐reassuring pattern, usually prolonged. Noninvasive electrocardiography may be more suitable prolonged due to improved patient comfort and signal quality. This study evaluates the performance experience four noninvasive devices assess candidate monitoring. Material methods Non‐critically sick women with singleton pregnancy from...
To evaluate the diagnostic yield of exome sequencing (ES) in fetuses and neonates with prenatally detected congenital diaphragmatic hernia (CDH) normal copy number variant (CNV) analysis.
Objective To compare the regenerative capacity of diseased bladder in a large animal model exstrophy with regeneration healthy using highly porous collagen scaffold. Materials and Methods Highly bovine type I scaffolds diameter 32 mm were prepared. In 12 fetal sheep was surgically created at 79 days’ gestation. Lambs born full term (140 gestation). After 1 week lesion reconstructed augmented scaffold (group 1). nine normal newborn lambs after birth 2). Functional (video‐urodynamics)...
Since the completion of Management Myelomeningocoele Study, maternal-fetal surgery for spina bifida has become a valid option expecting parents. More recently, multiple groups are exploring minimally invasive approach and recent outcomes have addressed many initial concerns with this approach. Based on previously published framework, we attempt to delineate developmental stage surgical techniques. Furthermore, discuss barriers performing randomized controlled trials comparing two...
Abstract Objective To investigate, from the perspective of women and partners, at what stage a termination pregnancy (TOP) for fetal anomalies psychosocial care (PSC) is most meaningful, topics should be discussed, who provide PSC. Method A cross‐sectional retrospective cohort study was conducted with consecutive series 76 36 completed semi‐structured online questionnaire. Results Overall, expressed greater need PSC than their partners. Parents preference receiving support maternal‐fetal...
Abstract Epigenetic programming is essential for lineage differentiation, embryogenesis and placentation in early pregnancy. In epigenetic association studies, DNA methylation often examined derived from white blood cells, although its validity to other tissues of interest remains questionable. Therefore, we investigated the tissue specificity epigenome-wide newborn placental tissues. Umbilical cord cells (UC-WBC, n = 25), umbilical mononuclear (UC-MNC, 10), human vein endothelial (HUVEC,...