A5014805400- Global Maternal and Child Health
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Artificial Intelligence in Healthcare and Education
- Global Public Health Policies and Epidemiology
- HIV/AIDS Research and Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Neonatal and fetal brain pathology
- Blood Pressure and Hypertension Studies
- Autopsy Techniques and Outcomes
- Ultrasound in Clinical Applications
- Paranormal Experiences and Beliefs
- ICT in Developing Communities
- Infant Development and Preterm Care
- Mobile Health and mHealth Applications
- Breastfeeding Practices and Influences
- Maternal and fetal healthcare
- Syphilis Diagnosis and Treatment
- Healthcare Systems and Reforms
- Ultrasound and Hyperthermia Applications
- Gestational Diabetes Research and Management
- Smart Systems and Machine Learning
- Poverty, Education, and Child Welfare
National HIV/AIDS/STI/TB Council
2019-2024
Wellcome Centre for Human Neuroimaging
2024
King's College London
2024
University of North Carolina at Charlotte
2024
Centre for Infectious Disease Research in Zambia
2013-2018
Well-functioning health systems need to utilize data at all levels, from the provider, local and national-level decision makers, in order make evidence-based needed adjustments improve quality of care provided. Over last 7 years, Doris Duke Charitable Foundation's African Health Initiative funded strengthening projects facility, district, and/or provincial level population health. Increasing data-driven making was a common strategy Mozambique, Rwanda Zambia. This paper describes similar...
Vital signs monitoring is a fundamental component of ensuring the health and safety women newborns during pregnancy, labor, childbirth. This often first step in early detection pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal neonatal morbidity mortality. Contemporary systems require numerous devices wired large base units; at least five separate with distinct user interfaces are commonly used detect uterine contractility, blood...
Ultrasound is indispensable to gestational age estimation and thus quality obstetrical care, yet high equipment cost the need for trained sonographers limit its use in low-resource settings. From September 2018 through June 2021, we recruited 4695 pregnant volunteers North Carolina Zambia obtained blind ultrasound sweeps (cineloop videos) of gravid abdomen alongside standard fetal biometry. We a neural network estimate from and, three test data sets, assessed performance artificial...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Accurate assessment of gestational age (GA) is essential to good pregnancy care but often requires ultrasonography, which may not be available in low-resource settings. This study developed a deep learning artificial intelligence (AI) model estimate GA from blind ultrasonography sweeps and incorporated it into the software low-cost, battery-powered device.
Zambia's under-resourced public health system will not be able to deliver on its health-related Millennium Development Goals without a substantial acceleration in mortality reduction. Reducing depend only upon increasing access care but also improving the quality of that is delivered. Our project proposes improve clinical and utilization care, through targeted improvement (QI) intervention delivered at facility community level.The being carried out 42 primary facilities serve largely rural...
Background:Mobile health (m-health) utilizes widespread access to mobile phone technologies expand services. Community workers (CHWs) provide first-level contact with facilities; combining CHW efforts m-health may be an avenue for improving primary care As part of a improvement project, pilot program was developed using phone-based application outreach, referral, and follow-up between the clinic community in rural Zambia.Materials Methods:The implemented at six sites. Computers were...
(Abstracted from JAMA 2024;332:649–657) Gestational age (GA) is critical for guiding obstetric decisions related to antenatal care and delivery. In high-income countries, GA typically measured via fetal biometry using high-resolution ultrasound machines operated by credentialed sonographers.
Fetal ultrasound is an important component of antenatal care, but shortage adequately trained healthcare workers has limited its adoption in low-to-middle-income countries. This study investigated the use artificial intelligence for fetal under-resourced settings.
Improved primary health care is needed in developing countries to effectively manage the growing burden of hypertension. Our objective was evaluate hypertension management Zambian rural clinics using process and outcome indicators assess screening, monitoring, treatment control high blood pressure. Better Health Outcomes through Mentoring Assessment (BHOMA) a 5-year, randomized stepped-wedge trial improved clinical service delivery underway 46 clinics. Clinical data were collected as part...
Women with HIV face an increased risk of preterm birth. 17 alpha-hydroxyprogesterone caproate (17P) has been shown in some trials to reduce early delivery among women a history spontaneous We investigated whether 17P would this HIV. did randomised, double-blind, placebo-controlled trial pregnant at the University Teaching Hospital and Kamwala District Health Centre Lusaka, Zambia. Eligible patients were aged 18 years or older confirmed HIV-1 infection, viable intrauterine singleton pregnancy...
<ns4:p><ns4:bold>Background: </ns4:bold>Sub-Saharan Africa bears a disproportionate burden of preterm birth and other adverse outcomes. A better understanding the demographic, clinical, biologic underpinnings these outcomes is urgently needed to plan interventions inform new discovery. </ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>The Zambian Preterm Birth Prevention Study (ZAPPS) prospective observational cohort established at Women Newborn Hospital (WNH) in Lusaka, Zambia. We recruit...
Sub-Saharan Africa bears a disproportionate burden of preterm birth and other adverse outcomes. A better understanding the demographic, clinical, biologic underpinnings these outcomes is urgently needed to plan interventions inform new discovery.
<ns4:p><ns4:bold>Background:</ns4:bold> Sub-Saharan Africa bears a disproportionate burden of preterm birth and other adverse outcomes. Not only is the background rate higher than in North America Europe, but many facilities lack essential equipment personnel resources to care for neonates. A better understanding demographic, clinical, biologic underpinnings urgently needed plan interventions inform new discovery. </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> The Zambian Preterm Birth...
Hypertension constitutes a growing burden of illness in developing countries like Zambia. Adequately screening and treating hypertension could greatly reduce the complications stroke coronary disease. Our objective was to determine prevalence identify current treatment practices among adult patients presenting for routine care rural health facilities Better Health Outcomes through Mentoring Assessments (BHOMA) project. We conducted retrospective analysis routinely collected clinical data...
<ns4:p><ns4:bold>Background</ns4:bold>: Few cohort studies of pregnancy in sub-Saharan Africa use rigorous gestational age dating and clinical phenotyping. As a result, incidence risk factors adverse birth outcomes are inadequately characterized.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: The Zambian Preterm Birth Prevention Study (ZAPPS) is prospective observational established to investigate at referral hospital urban Lusaka. This report describes ZAPPS phase I, enrolled August 2015...
To evaluate the accuracy of two portable ultrasound machines (PUM) in assessing fetal biometry and estimated gestational age (EGA).
This cross-sectional study of 3212 pregnant women assessed the field performance, acceptability, and feasibility two dual HIV/syphilis rapid diagnostic tests, Chembio DPP HIV-syphilis Assay SD Bioline Duo in antenatal clinics. Sensitivity specificity for HIV syphilis were calculated compared to Determine HIV-1/2 with Uni-Gold confirm positive results Treponema pallidum particle agglutination assay syphilis. RPR titers ≥1:4 used define active detection. Acceptability using self-reported...
<ns4:p><ns4:bold>Background</ns4:bold>: Few cohort studies of pregnancy in sub-Saharan Africa use rigorous gestational age dating and clinical phenotyping. As a result, incidence risk factors adverse birth outcomes are inadequately characterized.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: The Zambian Preterm Birth Prevention Study (ZAPPS) is prospective observational established to investigate at referral hospital urban Lusaka. This report describes ZAPPS phase I, enrolled August 2015...
The WHO guideline on the integration of family planning (FP) and pre-exposure HIV prophylaxis (PrEP) to enhance health women adolescent girls is reflected in Zambia Consolidated Guidelines for Treatment Prevention Infection, 2020. There however a dearth data PrEP FP Zambia. We describe oral services using Evidence Contraceptive Options Outcomes (ECHO) study experience at Kamwala District Health Center Lusaka, provision started October 2017, lasting ~11 months, utilized model where initial...
The Global Resilience Oral Workshops (GROW) Free and Strong programs take a strengths-based, positive youth development (PYD) approach to promoting thriving. Through both prevention (GROW Strong) intervention Free) exercises, these aim build character emotional resilience while also lowering unhealthy alcohol use. To meaningfully assess the impact of GROW on health PYD, ecologically psychometrically valid measures strengths were needed, with focus hope, forgiveness, spirituality, prudence,...
Objective: It is a widely held belief that the period of full moon associated with higher birth rates compared to periods when not full. We investigated whether more births occurred during in rural African population.Design: Data collected from 42 clinical sites Zambia Better Health Outcomes through Mentoring and Assessment (BHOMA) Study were evaluated. proportion pregnancies born theproportion would be expected if there no association.Main outcomes: Proportion moon.Measures: Demographics...