Daniel S. Hsia
A5018627458- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Eating Disorders and Behaviors
- Gestational Diabetes Research and Management
- Pharmacology and Obesity Treatment
- Health and Lifestyle Studies
- Adipose Tissue and Metabolism
- Children's Physical and Motor Development
- Birth, Development, and Health
- Vitamin D Research Studies
- Bariatric Surgery and Outcomes
- Diabetes Management and Education
- Nutritional Studies and Diet
- Obesity and Health Practices
- Long-Term Effects of COVID-19
- Diet, Metabolism, and Disease
- Cardiovascular and exercise physiology
- Breastfeeding Practices and Influences
Pennington Biomedical Research Center
2016-2025
Louisiana State University
2005-2025
University of Minnesota
2024
Emory University
2024
Obesity Society
2024
Baton Rouge Clinic
2018-2024
University of New Mexico
2024
Biomedical Research Institute
2023
Group for the Analysis of Development
2023
Our Lady of the Lake Children's Hospital
2022
Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin supplementation lowers diabetes is unknown.We randomly assigned adults who met at least two three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; hours after 75-g oral load, 140 199 glycated hemoglobin 5.7 6.4%) no diagnostic receive 4000 IU day D3 or placebo, regardless baseline serum level. The...
Efficacy and safety of the glucagon-like peptide 1 (GLP-1) analog oral semaglutide sodium-glucose cotransporter 2 inhibitor empagliflozin were compared in patients with type diabetes uncontrolled on metformin.Patients randomized to once-daily open-label treatment 14 mg (n = 412) or 25 410) a 52-week trial. Key end points change from baseline week 26 HbA1c (primary) body weight (confirmatory secondary). Two estimands addressed efficacy-related questions: policy (regardless trial product...
Eating earlier in the daytime to align with circadian rhythms metabolism enhances weight loss. However, it is unknown whether these benefits are mediated through increased energy expenditure or decreased food intake. Therefore, this study performed first randomized trial determine how meal timing affects 24-hour when intake and frequency matched.
The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown.Part 1 this ongoing phase 2-3 trial was open label for dose selection; part 2 an observer-blinded, placebo-controlled evaluation selected dose. In 2, we randomly assigned (6 months to 5 years age) a 3:1 ratio receive two 25-μg injections or placebo, administered 28 days apart. primary objectives were evaluate safety reactogenicity determine...
Antiobesity medication may be useful for the treatment of pediatric obesity, yet few safe and effective options exist. We evaluated phentermine/topiramate (PHEN/TPM) weight management in adolescents with obesity.This 56-week, randomized, double-blind trial enrolled 12 to less than 17 years age obesity. Participants were randomly assigned 1:1:2 receive either placebo (n=56), mid-dose PHEN/TPM (7.5 mg/46 mg; n=54), or top-dose (15 mg/92 n=113), respectively. All participants received lifestyle...
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
Summary Background Given children's low levels of physical activity and high prevalence obesity, there is an urgent need to identify innovative options. Objective This study aims test the effectiveness exergaming (video gaming that involves activity) reduce adiposity improve cardiometabolic health. Methods randomized controlled trial assigned 46 children with overweight/obesity a 24‐week or control condition. Intervention participants were provided console exergames, gameplay curriculum (1 h...
We examined the effects of metformin on diabetes prevention and subgroups that benefited most over 15 years in Diabetes Prevention Program (DPP) its follow-up, Outcomes Study (DPPOS).During DPP (1996-2001), adults at high risk developing were randomly assigned to masked placebo (n = 1,082) or 850 mg twice daily 1,073). Participants originally continued receive metformin, unmasked, DPPOS (2002-present). Ascertainment development was based fasting 2-h glucose levels after an oral tolerance...
Structured exergaming with prescribed moderate intensity physical activity has reduced adiposity among adolescents. The extent to which adolescents reduce when allowed self-select level is not known.The objective of the study was examine influence on adolescent girls' body composition and cardiovascular risk factors.This randomized controlled trial assigned 41 overweight obese girls aged 14 18 years group-based dance (36 h over 3 months) or a self-directed care control condition. Body size...
Two-thirds of pregnant women exceed gestational weight gain (GWG) recommendations. Because excess GWG is associated with adverse outcomes for mother and child, development scalable cost-effective approaches to deliver intensive lifestyle programs during pregnancy urgent.The aim this study was decrease the proportion who Institute Medicine (IOM) 2009 guidelines.In a parallel-arm randomized controlled trial, 54 (age 18-40 years) were overweight (n=25) or obese (n=29) enrolled test whether an...
Given the low levels of physical activity (PA) among adolescent girls in US, there is a need to identify tools motivate increased PA. Although limited evidence that adolescents transfer PA from one context another context, exergames (i.e., video games require gross motor activity) may act as gateway promote overall outside game play. The purpose this study was examine potential effects influences on external behaviors and psychological constructs) 12-week exergaming intervention girls' PA,...
OBJECTIVE Regression from prediabetes to normal glucose regulation (NGR) was associated with reduced incidence of diabetes by 56% over 10 years in participants the Diabetes Prevention Program Outcomes Study (DPPOS). In an observational analysis, we examined whether regression NGR also risk for microvascular disease (MVD). RESEARCH DESIGN AND METHODS Generalized estimating equations were used examine prevalence aggregate MVD at DPPOS year 11 people who regressed least once (vs. never) during...
Background: Adverse effects of metformin are primarily related to gastrointestinal (GI) intolerance that could limit titration an efficacious dose or cause discontinuation the medication. Because some side may be attributable shifts in GI microbiome, we tested whether a microbiome modulator (GIMM) used combination with would ameliorate symptoms. Methods: A 2-period crossover study design was 2 treatment sequences, either placebo period 1 followed by GIMM vice versa. Study periods lasted for...
OBJECTIVES: To determine the association of antibiotic use with weight outcomes in a large cohort children. METHODS: Health care data were available from 2009 to 2016 for 35 institutions participating National Patient-Centered Clinical Research Network. Participant inclusion required same-day height and measurements at 0 <12, 12 <30, 48 <72 months age. We assessed between any <24 age BMI z score overweight or obesity prevalence (5 years) age, secondary assessments...
Abstract Context Vitamin D regulates glucose homeostasis pathways, but effects of vitamin supplementation on β-cell function remain unclear. Objective To investigate the D3 insulin sensitivity and function. Methods This is a prespecified secondary analysis Type 2 Diabetes study. Overweight/obese adults at high risk for type diabetes (prediabetes) were randomly treated with 4000 IU or matching placebo daily 24 months. Main Outcome Disposition index (DI), as an estimate function, was...