A5008604264- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Adverse Reactions
- Neonatal and Maternal Infections
- Orthopedic Infections and Treatments
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Infectious Encephalopathies and Encephalitis
- Escherichia coli research studies
- Eosinophilic Disorders and Syndromes
- Muscle and Compartmental Disorders
- Vibrio bacteria research studies
- Infant Development and Preterm Care
- Mechanical Circulatory Support Devices
- Gut microbiota and health
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Herpesvirus Infections and Treatments
- Eosinophilic Esophagitis
- Food Security and Health in Diverse Populations
- Brain Metastases and Treatment
- Otolaryngology and Infectious Diseases
- Forensic Entomology and Diptera Studies
- Sepsis Diagnosis and Treatment
Avera McKennan Hospital & University Health Center
2020-2025
University of South Dakota
2020-2024
Avera Health
2017-2024
Rainbow Babies & Children's Hospital
2019-2023
Boston Children's Hospital
2023
Harvard University
2023
Baylor College of Medicine
2023
Case Western Reserve University
2022
University Hospitals of Cleveland
2022
Pediatric Infectious Diseases Society
2020
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
Abstract Background Penicillins remain reliable agents and are considered drugs of choice for select infections.1-3 Approximately 10% the US population report a penicillin allergy with majority labels placed in childhood.4,5 There is paucity data describing role socio-demographic factors to understand epidemiology pediatric especially rural settings.6 Methods This cross sectional retrospective demographic query patients 0-18 years old reported electronic medical record from 2018-2023...
Spinal phlegmon has rarely been reported in meningococcemia. Simultaneous polymicrobial infection occasionally as the etiology of meningitis. The development a spinal and optic neuritis complicated meningitis five-year-old male who presented with clinical sepsis Neisseria meningitidis (N. meningitidis) herpes simplex virus 1 (HSV-1) were demonstrated cerebrospinal fluid. Investigation potential immunocompromise revealed no identified deficit. Protracted antibiotics antiviral therapy...
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or failure refractory conventional therapies. Comprehensive reports of children and adolescents SARS-CoV-2–related ECMO for conditions, including multisystem inflammatory in (MIS-C) COVID-19, are needed. DESIGN: Case series patients from the Overcoming COVID-19 public health surveillance registry. SETTING:...
Background: Less than 5% of children who report penicillin allergy have clinically pertinent type 1 immunoglobulin E mediated hypersensitivity reaction by using direct oral amoxicillin challenge. Several pathways been developed to delabel challenge, mostly in the outpatient settings, but there is relative scarcity on published outcomes these pathways, especially inpatient pediatric settings. Objective: This study aimed evaluate performance an institutionally derived screening tool. Methods:...
The use of 16S rRNA sequencing in culture-negative infections has improved identification bacterial pathogens select scenarios, but its clinical impact requires further elucidation, especially the pediatric population. This retrospective study aims to determine utility on management our institution. Significant was identified 30 (40.5%) 74 samples (p < 0.0001). Of all specimens, pulmonary yielded most (n = 9, 30%), followed equally by joint fluid 6, 20%) and bone 20%), with no difference...
Abstract A three‐year‐old boy presented with fever, maculopapular rash involving palms and soles, hyponatremia two weeks following a tick bite. Empiric doxycycline that he was on discontinued negative initial rickettsial serology based the non‐endemicity of Rocky Mountain spotted fever (RMSF) in Northeast Ohio. He demonstrated high inflammatory markers met criteria for hemophagocytic lymphohistiocytosis (HLH). With working diagnosis macrophage activation syndrome secondary to presumed...
Isotretinoin or 13-cis-retinoic acid, a derivative of vitamin A, is highly effective therapy for severe and resistant acne. Its usage restricted worldwide because its teratogenic potential. The most common side effects are dermatologic, cheilitis, increased skin fragility, susceptibility to sunburns. Rare include myalgias arthralgias. It also causes transient laboratory abnormalities such as elevated creatine kinase (CK). Very few cases isotretinoin-induced muscle injury leading...
Abstract Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study...
Background: The development of broad-range polymerase chain reaction (BR-PCR) and next-generation sequencing techniques has significant implications for antimicrobial stewardship by increasing clinicians’ ability to provide a tailored regimen. We sought explore the clinical utility BR-PCR testing its impact on treatment among an adult cohort in large hospital system. Methods: retrospectively evaluated samples that underwent between 2017 2021 summarized their characteristics therapy....
Abstract Background Targeted antimicrobial regimens rely on prompt isolation and identification of the pathogen. When conventional gold standard culture-based methods fail to identify a pathogen, broad range PCR next-generation 16S rRNA sequencing has emerged as clinically useful increasingly frequent diagnostic tool. However, its impact in clinical decision making effect outcomes, particularly with negative results, remains poorly elucidated. This study aims evaluate adult infections....