Charlotte V. Hobbs
A5019807753- Kawasaki Disease and Coronary Complications
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Parasites and Host Interactions
- Vaccine Coverage and Hesitancy
- HIV/AIDS drug development and treatment
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Inflammasome and immune disorders
- Global Maternal and Child Health
- SARS-CoV-2 detection and testing
- Congenital Diaphragmatic Hernia Studies
- Parasite Biology and Host Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Mechanical Circulatory Support Devices
- Viral gastroenteritis research and epidemiology
- Metabolism and Genetic Disorders
University of Mississippi Medical Center
2016-2025
Children’s Institute
2024-2025
Mississippi State Department of Health
2021-2024
University of Alabama at Birmingham
2024
Saint Thomas Midtown Hospital
2024
University of New Mexico
2024
Children's of Alabama
2024
Jackson Memorial Hospital
2016-2023
Oak Ridge Institute for Science and Education
2023
Boston Children's Hospital
2023
Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) its temporal association with coronavirus disease 2019 (Covid-19) is important, given public health implications syndrome. We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, pediatric centers across United States. The case definition included six criteria: serious illness leading hospitalization, an age less than 21 years, fever that lasted at least 24 hours,...
<h3>Importance</h3> Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes. <h3>Objective</h3> To compare clinical characteristics and outcomes adolescents with MIS-C vs those severe coronavirus disease 2019 (COVID-19). <h3>Setting, Design, Participants</h3> Case series 1116 patients aged younger than 21 years hospitalized between March 15 October 31, 2020, at 66 US hospitals 31 states. Final date follow-up was January...
Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement children and adolescents is unclear.To understand range severity among associated with COVID-19.Case series patients (age <21 years) hospitalized between March 15, 2020, December positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals Overcoming COVID-19 public health...
The assessment of real-world effectiveness immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy.
Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious hyperinflammatory condition, which generally occurs 2-6 weeks after typically mild or asymptomatic infection with SARS-CoV-2, the virus that causes COVID-19 (1-3). In United States, BNT162b2 (Pfizer-BioNTech) vaccine currently authorized for use and adolescents aged 5-15 years under an Emergency Use Authorization fully licensed by Food Drug Administration persons ≥16 (4). Prelicensure randomized trials ≥5...
Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for disease 2019 (Covid-19), generated concern about immune evasion and duration protection from vaccines in children adolescents.Using a case-control, test-negative design, we assessed vaccine effectiveness against laboratory-confirmed Covid-19 leading hospitalization critical (i.e., receipt life support or death). From July 1, 2021, February...
Infants younger than 6 months of age are at high risk for complications coronavirus disease 2019 (Covid-19) and not eligible vaccination. Transplacental transfer antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) after maternal Covid-19 vaccination may confer protection in infants.
COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or might become in the future, protect them from COVID-19.§ Infants at risk life-threatening complications COVID-19, including acute respiratory failure (1). Evidence other vaccine-preventable diseases suggests that maternal immunization can provide protection infants, especially during high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent...
The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant severe acute respiratory syndrome 2 (SARS-CoV-2) in United States has offered an opportunity to assess real-world effectiveness BNT162b2 messenger RNA vaccine adolescents between 12 and 18 years age.
Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection
Abstract Background Information on outcomes of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA MRSA, respectively) bacteremia, particularly readmission, is scarce requires further research to inform optimal patient care. Methods We performed a retrospective analysis using the 2014 Nationwide Readmissions Database, capturing 49.3% US hospitalizations. identified MSSA MRSA bacteremia International Classification Diseases, Ninth Revision, Clinical Modification among patients...
As of December 14, 2020, children and adolescents aged <18 years have accounted for 10.2% coronavirus disease 2019 (COVID-19) cases reported in the United States.* Mitigation strategies to prevent infection with SARS-CoV-2, virus that causes COVID-19, among persons all ages, are important pandemic control. Characterization risk factors SARS-CoV-2 can inform efforts by parents, school program administrators, public health officials reduce transmission. To assess school, community, close...
BACKGROUND. Vaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication, and clinical trials have targeted zygote antigen Pfs25 decades. We reported a protein-protein conjugate vaccine formulated in alum adjuvant induced serum functional activity both US Malian adults. However, antibody levels declined rapidly, transmission-reducing required 4 doses. Functional immunogenicity durability must be improved before advancing transmission-blocking vaccines...
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing Alpha, Beta, Gamma, Delta variants by age-stratified analyses (<5, 5-11, 12-21 years) 177 pediatric patients hospitalized with severe acute COVID-19, MIS-C, convalescent samples outpatients mild COVID-19 during 2020 early 2021. Across all patients, less than 10% show neutralizing antibody titers Omicron. Children...
Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood.In a multicenter, case-control, public health investigation ages 5-18 years hospitalized from 1 July 2021 7 April 2022, we compared the odds being fully vaccinated (2 doses BNT162b2 vaccine ≥28 days...
Importance Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections (LRTIs) and infant hospitalization worldwide. Objective To evaluate characteristics outcomes RSV-related critical illness in US infants during peak 2022 RSV transmission. Design, Setting, Participants This cross-sectional study used a public health prospective surveillance registry 39 pediatric hospitals across 27 states. were admitted for 24 or more hours between October 17 December 16,...
In the apicomplexan protozoans motility and cell invasion are mediated by TRAP/MIC2 family of transmembrane proteins, members which link extracellular adhesion to intracellular actomyosin motor complex. Here we characterize a new member family, named TRAP-Like Protein (TLP), that is highly conserved within Plasmodium genus. Similar sporozoite protein, TRAP, ookinete CTRP, TLP possesses an domain architecture comprised von Willebrand factor A (vWA) thrombospondin type 1 (TSP1) domains, plus...
Response TeamAs of March 1, 2021, persons aged <18 years accounted for approximately 11% 28.4 million reported COVID-19 cases in the United States*; however, data on pediatric infections with SARS-CoV-2, virus that causes COVID-19, are limited (1).Surveys SARS-CoV-2 antibody seroprevalence suggest cumulative incidence infection is much higher than ascertained by (2,3).Evidence previous among young Mississippi was assessed testing antibodies to a convenience sample residual serum specimens...
Previous studies of severe acute respiratory syndrome coronavirus 2 infection in infants have incompletely characterized factors associated with illness or focused on born to mothers disease 2019 (COVID-19). Here we highlight demographics, clinical characteristics and laboratory values that differ between without COVID-19.Active surveillance was performed by the Overcoming COVID-19 network identify children adolescents 2-related hospitalized at 62 sites 31 states from March 15 December 27,...
Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming Network conducted a case-control study March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt vaccine dose (vaccine [VE]) hospitalization in infants and subset <3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all Case-patients (infants hospitalized outside...
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated vaccines.During December 19, 2021-October 29, 2023, Overcoming Network evaluated effectiveness (VE) ≥2 mRNA doses against hospitalization and critical illness among U.S. children adolescents aged 5-18 years, using a case-control design.Too...
To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome (MIS-C).Multicenter prospective cohort study conducted 25 United States pediatric hospitals. Patients <21-years-old, May 2020 to 2021 COVID-19 MIS-C with follow-up 2 4 months after admission. We assessed readmissions, persistent symptoms activity impairment, new morbidities. Multivariable regression was used calculate...
Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia.We performed unsupervised clustering on data from 1,526 (684 labeled MIS-C by clinicians) <21 years old hospitalized COVID-19-related illness admitted between 15 March 2020 31 December 2020. We compared prevalence of assigned labels clinical features among clusters, followed recursive feature elimination to identify...
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or failure refractory conventional therapies. Comprehensive reports of children and adolescents SARS-CoV-2–related ECMO for conditions, including multisystem inflammatory in (MIS-C) COVID-19, are needed. DESIGN: Case series patients from the Overcoming COVID-19 public health surveillance registry. SETTING:...
Importance Acute neurological involvement occurs in some patients with multisystem inflammatory syndrome children (MIS-C), but few data report and psychological sequelae, no investigations include direct assessments of cognitive function 6 to 12 months after discharge. Objective To characterize neurological, psychological, quality life sequelae MIS-C. Design, Setting, Participants This cross-sectional cohort study was conducted the US Canada. included MIS-C diagnosed from November 2020...