Stephanie P. Schwartz
A5060504843- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- Vaccine Coverage and Hesitancy
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Child and Adolescent Psychosocial and Emotional Development
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Hospital Admissions and Outcomes
- Inflammasome and immune disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Emergency and Acute Care Studies
- Prenatal Screening and Diagnostics
- Metabolism and Genetic Disorders
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Infectious Encephalopathies and Encephalitis
- Reproductive System and Pregnancy
- Attention Deficit Hyperactivity Disorder
- Pediatric Pain Management Techniques
- Chromosomal and Genetic Variations
University of North Carolina at Chapel Hill
2020-2025
University of North Carolina Hospitals
2018-2024
Child Mind Institute
2020-2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Children's Healthcare of Atlanta
2023
Texas Children's Hospital
2023
Children's Hospital of Philadelphia
2023
Emory University
2023
Nationwide Children's Hospital
2023
<h3>Importance</h3> Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes. <h3>Objective</h3> To compare clinical characteristics and outcomes adolescents with MIS-C vs those severe coronavirus disease 2019 (COVID-19). <h3>Setting, Design, Participants</h3> Case series 1116 patients aged younger than 21 years hospitalized between March 15 October 31, 2020, at 66 US hospitals 31 states. Final date follow-up was January...
Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement children and adolescents is unclear.To understand range severity among associated with COVID-19.Case series patients (age <21 years) hospitalized between March 15, 2020, December positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals Overcoming COVID-19 public health...
The assessment of real-world effectiveness immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy.
Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious hyperinflammatory condition, which generally occurs 2-6 weeks after typically mild or asymptomatic infection with SARS-CoV-2, the virus that causes COVID-19 (1-3). In United States, BNT162b2 (Pfizer-BioNTech) vaccine currently authorized for use and adolescents aged 5-15 years under an Emergency Use Authorization fully licensed by Food Drug Administration persons ≥16 (4). Prelicensure randomized trials ≥5...
Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for disease 2019 (Covid-19), generated concern about immune evasion and duration protection from vaccines in children adolescents.Using a case-control, test-negative design, we assessed vaccine effectiveness against laboratory-confirmed Covid-19 leading hospitalization critical (i.e., receipt life support or death). From July 1, 2021, February...
Infants younger than 6 months of age are at high risk for complications coronavirus disease 2019 (Covid-19) and not eligible vaccination. Transplacental transfer antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) after maternal Covid-19 vaccination may confer protection in infants.
COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or might become in the future, protect them from COVID-19.§ Infants at risk life-threatening complications COVID-19, including acute respiratory failure (1). Evidence other vaccine-preventable diseases suggests that maternal immunization can provide protection infants, especially during high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent...
The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant severe acute respiratory syndrome 2 (SARS-CoV-2) in United States has offered an opportunity to assess real-world effectiveness BNT162b2 messenger RNA vaccine adolescents between 12 and 18 years age.
This study examined gender differences in 79 high‐school students' attitudes towards their science classes, perceptions of and scientists, views about majoring science. The identified some the subtleties underlying females' low participation in, interest documented previous research. Four themes emerged from responses on rating scales questionnaire. First, even when females planned to major science, they were more interested than males people‐oriented aspects majors. Second, biology was one...
Background Healthcare is approaching a tipping point as burnout and dissatisfaction with work-life integration (WLI) in healthcare workers continue to increase. A scale evaluating common behaviours actionable examples of WLI was introduced measure balance. Objectives (1) Explore differences by role, specialty other respondent demographics large system. (2) Evaluate the psychometric properties climate scale, extent which it acts like climate, or group-level norm when used at work setting...
Pfizer-BioNTech COVID-19 vaccine is authorized for use in children and adolescents aged 12-15 years licensed by the Food Drug Administration (FDA) persons ≥16 (1). A randomized placebo-controlled trial demonstrated an efficacy of 100% (95% confidence interval [CI] = 75.3%-100%) preventing outpatient (2); however, data among on effectiveness (VE) against real-world settings are limited, especially hospitalized patients. In early September 2021, U.S. pediatric hospitalizations reached highest...
Background Improving the resiliency of healthcare workers is a national imperative, driven in part by having minimal exposure to skills and culture achieve work–life balance (WLB). Regardless current policies, feel compelled work more take less time recover from work. Satisfaction with WLB has been measured, as conflict, but how frequently engage specific behaviours rarely assessed. Measurement may have advantages over measurement perceptions; accurately reflect can be targeted leaders for...
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing Alpha, Beta, Gamma, Delta variants by age-stratified analyses (<5, 5-11, 12-21 years) 177 pediatric patients hospitalized with severe acute COVID-19, MIS-C, convalescent samples outpatients mild COVID-19 during 2020 early 2021. Across all patients, less than 10% show neutralizing antibody titers Omicron. Children...
Multisystem inflammatory syndrome in children (MIS-C), linked to antecedent severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, is associated with considerable morbidity. Prevention of SARS-CoV-2 infection or disease 2019 (COVID-19) by vaccination might also decrease MIS-C likelihood.In a multicenter, case-control, public health investigation ages 5-18 years hospitalized from 1 July 2021 7 April 2022, we compared the odds being fully vaccinated (2 doses BNT162b2 vaccine ≥28 days...
Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection
Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming Network conducted a case-control study March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt vaccine dose (vaccine [VE]) hospitalization in infants and subset <3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all Case-patients (infants hospitalized outside...
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated vaccines.During December 19, 2021-October 29, 2023, Overcoming Network evaluated effectiveness (VE) ≥2 mRNA doses against hospitalization and critical illness among U.S. children adolescents aged 5-18 years, using a case-control design.Too...
To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome (MIS-C).Multicenter prospective cohort study conducted 25 United States pediatric hospitals. Patients <21-years-old, May 2020 to 2021 COVID-19 MIS-C with follow-up 2 4 months after admission. We assessed readmissions, persistent symptoms activity impairment, new morbidities. Multivariable regression was used calculate...
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood has high sensitivity adults with disease 2019 (COVID-19), but pediatric patients is unclear. Recent data suggest that persistent SARS-CoV-2 spike antigenemia may contribute to multisystem inflammatory children (MIS-C). We quantified nucleocapsid (N) and (S) either COVID-19 or MIS-C using ultrasensitive immunoassays (Meso Scale Discovery).Plasma was collected from inpatients (<21 years) enrolled across...
Importance Neurological manifestations during acute SARS-CoV-2–related multisystem inflammatory syndrome in children (MIS-C) are common hospitalized patients younger than 18 years and may increase risk of new neurocognitive or functional morbidity. Objective To assess the association severe neurological a hospital admission with morbidities at discharge. Design, Setting, Participants This prospective cohort study from 46 centers 10 countries included who were for SARS-CoV-2 MIS-C between...
Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia.We performed unsupervised clustering on data from 1,526 (684 labeled MIS-C by clinicians) <21 years old hospitalized COVID-19-related illness admitted between 15 March 2020 31 December 2020. We compared prevalence of assigned labels clinical features among clusters, followed recursive feature elimination to identify...
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been used successfully to support adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related cardiac or failure refractory conventional therapies. Comprehensive reports of children and adolescents SARS-CoV-2–related ECMO for conditions, including multisystem inflammatory in (MIS-C) COVID-19, are needed. DESIGN: Case series patients from the Overcoming COVID-19 public health surveillance registry. SETTING:...