A5030029867- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Neonatal and fetal brain pathology
- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Breast Lesions and Carcinomas
- Intracranial Aneurysms: Treatment and Complications
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Breast Cancer Therapies
- Angiogenesis and VEGF in Cancer
- Endometriosis Research and Treatment
- Testicular diseases and treatments
- Kawasaki Disease and Coronary Complications
- Cardiac Ischemia and Reperfusion
- Brain Metastases and Treatment
- Glycogen Storage Diseases and Myoclonus
- Cancer Risks and Factors
- Foreign Language Teaching Methods
- Infectious Encephalopathies and Encephalitis
- Advanced MRI Techniques and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Iowa
2021-2025
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2017-2021
Innsbruck Medical University
2008-2021
University of Iowa Stead Family Children’s Hospital
2020
Northwestern University
2017-2019
Lurie Children's Hospital
2016-2019
BrustGesundheitZentrum Tirol
2017-2018
Wayne State University
2017
Universität Innsbruck
2008-2015
University Hospital Innsbruck
2014
Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate interrater reliability (IRR), Burden AmplitudeS and Epileptiform Discharges (BASED) score shown promise for reliable interictal assessment syndrome. Our aim was to develop a BASED training program assess IRR among learners. We hypothesized moderate or...
<b><i>Article abstract</i></b> Local intra-arterial lysis using recombinant tissue plasminogen activator (rTPA) was performed in a 6 and 2/3-year-old patient with major cardioembolic ischemic stroke 48 hours after intracardiac surgery. Selective application of 2.5 mg rTPA (0.11 mg/kg body weight) resulted recanalization the occluded cerebral vasculature good neurologic recovery.
Abstract UDP ‐glucose dehydrogenase ( UGDH ) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings variants. Both presented around 6 months delay elevated creatinine kinase. Sibling A developed epilepsy at age 9 years. Muscle biopsy from sibling showed necrotizing myopathy reduced matriglycan immunostaining. Western blot revealed α‐dystroglycan abnormally low molecular weight. The shared...
<title>Abstract</title> The ability of the forebrain to track and integrate respiratory signals, a process known as breathing interoception, is critical for detecting threats ensuring survival, yet its neural mechanisms remain largely unknown. Using human intracranial recordings, we identified widespread synchronization between oscillations rhythms across wakefulness, sleep, external mechanical ventilation. During localized sites within interoceptive regions such insula, somatosensory...
The objective of this case-control study 242 reproductive-age women was to determine the concentration afamin in serum and peritoneal fluid with without endometriosis test as a diagnostic marker endometriosis. Afamin levels were altered significantly compared disease-free controls, correlated vitamin E levels, are consistent increased oxidative stress cavity
This report is based on a consecutive series of 162 patients with aneurysmal subarachnoid haemorrhage (SAH), including 22 (14%) recurrent SAH, who were treated within 72 h after the most recent bleed. Of haemorrhage: 68% in poor clinical condition (Hunt & Hess grade 4-5); 73% presented intracerebral (ICH); 41% developed delayed ischaemic infarctions from chronic arterial spasm; 14% made good recovery, while died. 140 single bleed: 34% 33% ICH; 22% infarctions; 53% 19% Our results suggest...
Highly sensitive reporter-gene assays have been developed that allow both the direct VEGF neutralizing activity of bevacizumab and ability to activate antibody dependent cellular cytotoxicity (ADCC) be quantified rapidly in a highly specific manner. The use these has shown 46 patients with ovarian cancer following four cycle treatment, longitudinal samples from two respond therapy small cohort glioblastoma, there is reasonably good correlation between drug levels determined by ELISA...
Abstract BACKGROUND Pathological complete response (pCR) after neoadjuvant systemic therapy is correlated with better prognosis in HER2-positive, early breast cancer. Bevacizumab (B) was shown to add efficacy treatment HER2-negative, cancer terms of pCR-rate but failed the adjuvant setting both, HER2-negative and HER2-positive disease. The role B not defined. Thus, ABCSG-32 designed as a randomized phase II trial evaluate efficacy, non-cardiac safety, cardiac toxicity when added docetaxel +...
This study aims to investigate glial cell derived neurotrophic factor (GDNF) levels in newborns' umbilical cord blood and cerebrospinal fluid across various perinatal growth parameters clinical conditions.Cord from 20 newborns 58 residual CSF samples (stored after completion of testing) were collected. GDNF determined using ELISA kits R&D Systems triplicates with appropriate controls eliminate background.Cord significantly higher (p=0.004) preterm (n=6) (115.05±57.17,pg/ml) when compared...
BMI has been suggested to impact on estrogenic activity in patients receiving anastrozole resulting a reduced treatment efficacy obese women. Current evidence this regard is controversially discussed. Since estradiol inversely correlated with gonadotropins it can be assumed that an of also reflected by gonadotropin plasma concentrations. We aim at investigating the hormonal state breast cancer (BC) indicated LH, FSH and SHBG as well estradiol.We determined gonadotropin-, estradiol-...
Investigators from the Accident Vasculaire Cérébral de nouveau-né (AVCnn) Study Group, a multicenter registry in France, examined outcomes at 7 years of age children previously identified with neonatal arterial ischemic stroke (NAIS).
Abstract Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk adverse reactions. We present case neonate who developed...
Influenza-associated encephalopathy/encephalitis (IAE) can result in serious neurological complications. We report a 4-year-old healthy female child with the diagnosis of IAE. Her clinical course was complicated by temporary visual impairment and significant motor deficits. unique ophthalmological findings have little precedent previous literature.