A5016490053- Aquaculture Nutrition and Growth
- Renal function and acid-base balance
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Aquaculture disease management and microbiota
- Acute Myeloid Leukemia Research
- Reproductive biology and impacts on aquatic species
- Pancreatic function and diabetes
- Multiple Myeloma Research and Treatments
- Physiological and biochemical adaptations
- Retinoids in leukemia and cellular processes
- Animal Genetics and Reproduction
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- MicroRNA in disease regulation
- Education and Professional Development
- Ion Transport and Channel Regulation
- Drug-Induced Hepatotoxicity and Protection
- Dupuytren's Contracture and Treatments
- Microplastics and Plastic Pollution
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nephrotoxicity and Medicinal Plants
- Renin-Angiotensin System Studies
- Renal and Vascular Pathologies
- Glioma Diagnosis and Treatment
Clinica Universidad de Navarra
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Sergio Arboleda University
2023
Universitat de Barcelona
2009-2015
Hospital Universitario Insular de Gran Canaria
1993-2009
Complejo Hospitalario de Salamanca
2009
Centro Regional de Hemodonación
2000
University of Pisa
1998
Universidad de Murcia
1993-1995
Background The prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established remain a controversial matter.Design Methods Between 1996 2005, 739 newly diagnosed enrolled two consecutive trials (PETHEMA LPA96 LPA99) received induction therapy all-trans retinoic acid idarubicin. Consolidation comprised three courses anthracycline monochemotherapy (LPA96), reinforced doses idarubicin an intermediate or high relapse...
Background Acute promyelocytic leukemia is a subtype of acute myeloid characterized by the t(15;17). The incidence and prognostic significance additional chromosomal abnormalities in still controversial matter.Design Methods Based on cytogenetic data available for 495 patients with enrolled two consecutive PETHEMA trials (LPA96 LPA99), we analyzed incidence, characteristics, outcome without who had been treated all-trans retinoic acid plus anthracycline monochemotherapy induction...
Abstract —Cyclooxygenase-2 (COX-2) has been identified in renal tissues under normal conditions, with its expression enhanced during sodium restriction. To evaluate the role of COX-2–derived metabolites regulation function, we infused a selective inhibitor (nimesulide) anesthetized dogs or low intake. The effects elicited by nimesulide and non–isozyme-specific (meclofenamate) were compared In ex vivo assays, meclofenamate, but not nimesulide, prevented platelet aggregation arachidonic acid....
The objective of the present study was to examine, in anesthetized dogs, possible interaction between prostaglandins (PG) and nitric oxide (NO) mediating renal response an extracellular volume expansion (ECVE). ECVE examined during 1) intrarenal infusion a PG synthesis inhibitor, 2) administration NO 3) simultaneous inhibition right kidney. Compared with control group, ECVE-induced increments sodium excretion fractional lithium were not affected by inhibition. did induce changes hemodynamics...
Type 1 diabetes subjects are characterized by impaired direct pathway synthesis of hepatic glycogen that is unresponsive to insulin therapy. Since it not known whether this an irreversible defect insulin-dependent diabetes, and indirect fluxes were quantified in streptozotocin (STZ)-induced diabetic rats compared with STZ received subcutaneous or intraperitoneal (I-SC I-IP). Three groups studied at 18 days post-STZ treatment. One group was administered I-SC another I-IP as two daily...
In liver, through the reaction catalysed by alanine aminotransferase (ALT), becomes an effective precursor for gluconeogenesis. present study amino-oxyacetate (AOA) was used to evaluate its effect on liver ALT activity of carnivorous fish Sparus aurata . Moreover, derived metabolic effects metabolites and other key enzymes glycolysis, gluconeogenesis pentose phosphate pathway were also studied. A dose-effect-dependent inhibition AOA hepatic cytosolic mitochondrial observed in vitro vivo ,...
The objective of this study was to examine the renal effects changes in intrarenal angiotensin II levels during administration a cyclooxygenase inhibitor, when nitric oxide synthesis is reduced. In first group dogs, meclofenamate and subpressor dose L-NAME induced an increase (P < 0.05) arterial pressure (14 +/- 2 mm Hg), decrease RBF (180 13 111 10 mL/min) GFR (37 3 24 5 mL/min), reduction excretory response sodium load. second group, converting enzyme inhibitor prevented pressure,...
Abstract —Previous studies have reported evidence of an important interaction between nitric oxide (NO) and prostaglandins in the acute regulation renal function. The objective this study was to determine conscious dogs whether effects prolonged administration a cyclooxygenase inhibitor are enhanced when NO synthesis is reduced. Meclofenamate infusion (5 μg · kg −1 min ) during 4 consecutive days (n=8) elicited continuous decrease ( P <0.05) blood flow plasma renin activity transitory...
This study was undertaken to determine, in anesthetized dogs, the role of renal prostaglandins (PG) mediating natriuretic response increased interstitial hydrostatic pressure (RIHP) during extracellular volume expansion (ECVE) with isotonic saline. It also determined if intrarenal angiotensin II (ANG II) effects ECVE are potentiated by inhibition PG synthesis. induced similar elevations RIHP, natriuresis, and fractional lithium excretion dogs treated (n = 7) not a synthesis inhibitor 5). In...
Alanine aminotransferase (Alt) provides a molecular link between carbohydrate and amino acid metabolism. In the cell context, predominant Alt isozyme is located in cytosol. To gain insight into transcriptional regulation of cytosolic alt gene ( calt ), we cloned characterized promoter from gilthead sea bream Sparus aurata ). Transient transfection bass larvae cells with deleted constructs electrophoretic mobility shift assays allowed us to identify p300 c-Myb as new factors expression....
This study examined, in anesthetized dogs, the possible interactions between nitric oxide (NO) and angiotensin II (ANG II) mediating renal response to an extracellular volume expansion (ECVE). It was found that intrarenal maintenance of ANG levels (group 1) or NO synthesis inhibition 2) did not induce changes hemodynamics but reduced (P < 0.05) ECVE-induced increments sodium excretion fractional lithium (FeLi). In third group, inhibited during blockade. this group increment modify FeLi....
Abstract —The benefits of the simultaneous administration low doses a calcium antagonist and converting enzyme inhibitor in treatment hypertension renal vasoconstriction are well established. The objective this study was to evaluate whether converting-enzyme have beneficial effects treating alterations induced by acute cyclooxygenase when nitric oxide synthesis is reduced. These were examined anesthetized dogs before during an sodium load. It found that intrarenal infusion meclofenamate (5...