A5041929328- Heavy Metal Exposure and Toxicity
- Child Nutrition and Water Access
- Arsenic contamination and mitigation
- Folate and B Vitamins Research
- Trace Elements in Health
- Pregnancy and Medication Impact
- Epilepsy research and treatment
- Spinal Dysraphism and Malformations
- Statistical Methods and Inference
- Birth, Development, and Health
- Fluoride Effects and Removal
- Neonatal and fetal brain pathology
- Air Quality and Health Impacts
- Energy and Environment Impacts
- Analytical chemistry methods development
- Pesticide Exposure and Toxicity
- Congenital Anomalies and Fetal Surgery
- Prenatal Screening and Diagnostics
- Fault Detection and Control Systems
- Cystic Fibrosis Research Advances
- Esophageal and GI Pathology
- Malaria Research and Control
- Environmental and Social Impact Assessments
- Human Health and Disease
- Cerebrospinal fluid and hydrocephalus
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
National Institute of Neurosciences & Hospital
2023
Boston University
2023
Boston Children's Museum
2015-2022
Pennsylvania State University
1992
Goa Medical College
1981
Presidency University
1969-1977
Government of West Bengal
1975
Because humans are invariably exposed to complex chemical mixtures, estimating the health effects of multi-pollutant exposures is critical concern in environmental epidemiology, and regulatory agencies such as U.S. Environmental Protection Agency. However, most studies focus on single agents or consider simple two-way interaction models, part because we lack statistical methodology more realistically capture complexity mixed exposures. We introduce Bayesian kernel machine regression (BKMR) a...
Background: Exposure to chemical mixtures is recognized as the real-life scenario in all populations, needing new statistical methods that can assess their complex effects. Objectives: We aimed joint effect of utero exposure arsenic, manganese, and lead on children’s neurodevelopment. Methods: employed a novel approach, Bayesian kernel machine regression (BKMR), study coexposure neurodevelopment using an adapted Bayley Scale Infant Toddler Development™. Third Edition, 825 mother–child pairs...
The overall effect of an exposure on outcome, in the presence a mediator with which may interact, can be decomposed into four components that correspond to portion is due: (i) neither mediation nor interaction; (ii) just interaction (but not mediation); (iii) both and (iv) interaction). This four-way decomposition unifies methods attribute effects interactions assess mediation. We introduce Stata command med4way estimate causal contrasts arise this decomposition. Med4way implemented as...
Early life lead exposure might be a risk factor for neurocognitive impairment in adulthood. We sought to assess the relationship between early environmental and intellectual function also attempted identify which time period blood-lead concentrations are most predictive of adult outcome. recruited adults Boston area who had participated as newborns young children prospective cohort study that examined childhood function. IQ was measured using Wechsler Abbreviated Scale Intelligence (WASI)....
The people of Bangladesh are currently exposed to high concentrations arsenic and manganese in drinking water, as well elevated lead many regions. objective this study was investigate associations between environmental exposure these contaminants neurodevelopmental outcomes among Bangladeshi children. We evaluated data from 524 children, members an ongoing prospective birth cohort established the effects prenatal early childhood Sirajdikhan Pabna Districts Bangladesh. Water collected...
Background: the relationship between arsenic and birth weight is not well understood.the objective was to evaluate causal prenatal exposure considering potential mediation effects of gestational age maternal gain during pregnancy using structural equation models.Methods: a prospectively enrolled cohort pregnant women recruited in Bangladesh from 2008 2011.arsenic measured personal drinking water at time enrollment (gestational <16 weeks, n = 1,140) toenails collected ≤1 month postpartum (n...
During the conduct of a cohort study intended to associations between mixed metal exposures and child health outcomes, we found that 78% 309 children aged 20-40 months evaluated in Munshiganj District Bangladesh had blood lead concentrations ≥5 µg/dL 27% ≥10 µg/dL. Environmental sources such as spices (e.g., turmeric, which has already faced recalls due high levels) may be potential route exposure. We conducted visits homes 28 randomly selected from among low concentration groups. visits,...
Pesticide exposure during pregnancy is thought to adversely affect fetal growth, which in turn may impact child but results have been inconsistent across studies and few explored these effects developing countries.To quantify urinary concentrations of pesticide biomarkers early (<16 weeks' gestation), estimate the association with preterm birth, low birth weight, small for gestational age, stunting at ~1 2 years age.Eight were quantified urine collected from 289 pregnant women (aged 18-40...
Greater understanding of the pathways through which an environmental mixture operates is important to design effective interventions. We present new methodology estimate natural direct and indirect effects controlled a complex exposure on outcome mediator variable. implement Bayesian Kernel Machine Regression (BKMR) allow for all possible interactions nonlinear (1) co‐exposures mediator, (2) outcome, (3) selected covariates and/or outcome. From posterior predictive distributions we simulate...
OBJECTIVES The American Academy of Pediatrics recommends that children and adolescents with Down syndrome receive anticipatory guidance regarding development behavior. However, few tools provide specific on developmental norms for syndrome. Our objective was to estimate age ranges at which achieve milestones facilitate screening by pediatric practitioners. METHODS We used standardized questionnaires obtain information from clinicians caregivers who received care the Boston Children’s...
Background: Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD).Objectives: We attempted to assess the relationship between potential biomarkers for AD among young men women. also whether was changes in AD-related genes.Methods: used sandwich enzyme-linked immunosorbent assays (ELISA) measure plasma concentrations amyloid β Aβ40 Aβ42 55 adults who had participated as newborns children a...
Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. A prospective cohort was recruited in Bangladesh from 2008–2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic measured personal drinking water using inductively-coupled plasma mass spectrometry. Questionnaires collected data at enrollment, 28 WGA, and within one month of delivery. Adjusted odds ratios (aORs) 95%...
Arsenic induces neural tube defects in several animal models, but its potential to cause humans is unknown. Our objective was investigate the associations between maternal arsenic exposure, periconceptional folic acid supplementation, and risk of posterior defect (myelomeningocele) among a highly exposed population rural Bangladesh. We performed case–control study that recruited physician-confirmed cases from community health clinics served by Dhaka Community Hospital Bangladesh, as well...
Lead toxicity is of particular public health concern given its near ubiquitous distribution in nature and established neurotoxicant properties. Similar ubiquity ability to inhibit neurodevelopment, early childhood stunting affects an estimated 34 % children under 5 low- middle-income countries. Both lead have been shown be associated with decreased although the relationship between these burdens underexplored. The association exposure has previously established, yet limited data are...
Studies have evaluated environmental exposure to toxic metals such as arsenic (As), cadmium (Cd), manganese (Mn), or lead (Pb) on birth size; however, information potential effects of exposures metal mixtures is limited.We assessed the association between (As, Cd, Mn, Pb) in umbilical cord blood and neonate size Bangladeshi children.In this cohort study, pregnant women who were ≥18 years age with an ultrasound-confirmed singleton pregnancy ≤16wk gestation recruited from two Bangladesh...
Importance Acute neurological involvement occurs in some patients with multisystem inflammatory syndrome children (MIS-C), but few data report and psychological sequelae, no investigations include direct assessments of cognitive function 6 to 12 months after discharge. Objective To characterize neurological, psychological, quality life sequelae MIS-C. Design, Setting, Participants This cross-sectional cohort study was conducted the US Canada. included MIS-C diagnosed from November 2020...
Neural tube defects are debilitating birth that occur when the developing neural plate fails to close in early gestation. Arsenic induces animal models, but whether environmental arsenic exposure increases risk of humans is unknown.We describe a new case-control study Bangladesh, country currently experiencing an epidemic poisoning through contaminated drinking water. We plan understand how influences mechanisms include disruption maternal glucose and folate metabolism, as well epigenetic...
Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification health effects associated with a critical goal for establishing policy sufficiently protective human health. The exposure an mixture poses several statistical challenges. It is often case that multiple pollutants interact each affect outcome. Further, exposure-response relationship between outcome some exposures, such as metals, can exhibit complex, nonlinear forms, since exposures...
Neural tube defects are a pressing public health concern despite advances in prevention from folic acid-based strategies. Numerous chemicals, particular arsenic, have been associated with neural animal models and could influence risk humans.
Arsenic is associated with lung disease and experimental models suggest that arsenic-induced degradation of the chloride channel CFTR (cystic fibrosis transmembrane conductance regulator) a mechanism arsenic toxicity. We examined associations between exposure, sweat concentration (measure function), pulmonary function among 269 adults in Bangladesh. Participants ≥ 60 mmol/L had higher exposures than those < (water: median 77.5 µg/L versus 34.0 µg/L, p = 0.025; toenails: 4.8 µg/g 3.7 µg/g,...