James Chan
A5053334484- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Family and Disability Support Research
- Neurogenetic and Muscular Disorders Research
- Child Nutrition and Feeding Issues
- Cerebral Palsy and Movement Disorders
- Attention Deficit Hyperactivity Disorder
- Infant Development and Preterm Care
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Genetics and Neurodevelopmental Disorders
- Dysphagia Assessment and Management
- Dental Health and Care Utilization
- Biochemical Acid Research Studies
- COVID-19 Impact on Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric health and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Neurological diseases and metabolism
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
Massachusetts General Hospital
2015-2024
Amyotrophic Lateral Sclerosis Association
2024
Harvard University
2014-2023
Clinical Research Institute
2023
Northwestern University
2023
Public Health Ontario
2023
University of Toronto
2023
University of California, San Diego
2023
National Institute of Neurological Disorders and Stroke
2023
Toronto Western Hospital
2023
Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental models. The efficacy safety of a combination the two compounds persons with amyotrophic lateral sclerosis (ALS) are not known.
Abstract An orally administered, fixed‐dose coformulation of sodium phenylbutyrate‐taurursodiol (PB‐TURSO) significantly slowed functional decline in a randomized, placebo‐controlled, phase 2 trial ALS (CENTAUR). Herein we report results long‐term survival analysis participants CENTAUR. In CENTAUR, adults with were randomized 2:1 to PB‐TURSO or placebo. Participants completing the 6‐month (24‐week) eligible receive open‐label extension. all‐cause mortality (35‐month maximum follow‐up...
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
To examine rehabilitation interventions and resulting physical activity patterns of patients managed in acute stroke units to help inform development a randomized controlled trial very early rehabilitation.An open observational study patient therapist report interventions. A survey unit resources.Patients less than 14 days post-stroke from 5 metropolitan were observed over 2 consecutive weekdays at 10-minute intervals between 08.00 h 17.00 h. Physical activity, location person(s) present...
Objective: A randomized pilot trial of gastrointestinal (GI) symptoms targeting probiotic for quality life in autism spectrum disorder (ASD). Methods: Thirteen children, 3-12 years age with ASD, anxiety, and GI symptoms, were into a crossover 8 weeks each on VISBIOME placebo separated by 3-week washout. contains eight species, mostly Lactobacillus Bifidobacterium. Primary outcome was the Pediatric Quality Life Inventory (PedsQL) module. Secondary outcomes included gut microbiota analysis,...
To characterize [11 C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary (PLS). We have previously shown increased the precentral gyrus a small group of ALS patients. Herein, we confirm our initial finding, study longitudinal changes, gray versus white matter distribution larger cohort patients PLS.Eighty-five participants including 53 ALS, 11 PLS, 21 healthy controls underwent integrated PET-magnetic resonance imaging....
Objective To characterize the gut microbiota in people with amyotrophic lateral sclerosis (ALS) relative to controls and test hypothesis that butyrate-producing bacteria are less abundant gastrointestinal tracts of ALS (PALS). Methods: We conducted a case–control study at Massachusetts General Hospital compare controls. Metagenomic shotgun sequencing was performed on DNA extracted from stool samples 66 (PALS), 61 healthy (HC), 12 neurodegenerative (NDC). Taxonomic metagenomic profiles were...
The amyotrophic lateral sclerosis (ALS) trial outcome measures are clinic based. Active and passive smartphone data can provide important longitudinal information about ALS progression outside the clinic.We used Beiwe, a research platform for smartphone-based digital phenotyping, to collect active (self-report ALSFRS-R surveys speech recordings) (phone sensors logs) from patients with approximately 24 weeks. In clinics, at baseline every 3 months, we collected vital capacity, ALSFRS-R,...
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms other health effects after the acute phase of infection; termed post-acute sequelae (PASC), long COVID. The characteristics, prevalence, trajectory and mechanisms PASC are ill-defined. objectives Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study Adults (RECOVER-Adult) to: (1) characterize prevalence; (2) symptoms, organ dysfunction, natural history, distinct phenotypes PASC; (3)...
A recent meta-analysis documented a significant statistical association between mild traumatic brain injury (mTBI) and attention deficit hyperactivity disorder (ADHD) (Adeyemo et al., 2014), but the direction of this effect was unclear. In study, we hypothesized that ADHD would be an antecedent risk factor for mTBI. Participants were student athletes ages 12 to 25 who had sustained mTBI Controls similar age sex selected from studies youth with without ADHD. Subjects assessed symptoms ADHD,...
Both working memory (WM; a brain system that provides temporary storage and manipulation of the information) attention-deficit/hyperactivity disorder (ADHD) have been associated with educational deficits. Since WM deficits are prevalent in children ADHD, main aim present study was to examine whether driven by or effect ADHD itself.Participants were referred youth (N = 276) without 241) ascertained from pediatric psychiatric sources. Assessment included measures psychiatric, psychosocial,...
<h3>Importance</h3> The Extension for Community Health Outcomes (ECHO) model is a widely adopted technology-based training primary care physicians and practitioners (PCPs) to patients with complex conditions. Despite its popularity, our knowledge, direct effects of ECHO on clinical practice have not been tested in large-scale study. <h3>Objective</h3> To test the effectiveness as applied autism whether it resulted improved practice, self-efficacy regarding screening comorbidity management....
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A 16 Gb 4-state MLC NAND flash memory augments the sustained program throughput to 34 MB/s by fully exercising all available cells along a selected word line and using additional performance enhancement modes. The same chip operating as an 8 SLC device guarantees over 60 programming throughput. newly introduced All Bit Line (ABL) architecture has multiple advantages when higher is targeted it was...
Objective: Amyotrophic lateral sclerosis (ALS) has profound effects on people with ALS (PALS) and caregivers. There is a paucity of research detailing comparing PALS caregiver day-to-day perspectives ALS. Methods: A survey developed collaboratively by The Association panel experts in care was designed to broadly sample the experience caregivers respect physical emotional symptoms, efficacy treatment approaches, goals for future treatments. Specific symptoms assessed consisted fatigue, pain,...
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 11 (Gibson et al., 2006; Cho 2010). attenuates CNS microglial activation secretion pro-inflammatory cytokines (Fujimoto 1999; In vitro evidence suggests that ibudilast neuroprotective by suppressing neuronal cell death induced activation. People with ALS have increased measured [11C]PBR28-PET in the motor cortices. The primary objective to determine impact on reducing glial...
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...
ABSTRACT Introduction : Urate has been identified as a predictor of amyotrophic lateral sclerosis (ALS) survival in some but not all studies. Here we leverage the recent expansion Pooled Resource Open‐Access ALS Clinical Trials (PRO‐ACT) database to study association between urate levels and survival. Methods data 1,736 participants from PRO‐ACT were analyzed. Cox proportional hazards regression models used evaluate associations at trial entry Results After adjustment for potential...
Neuroinflammation is increasingly tied to disease progression in amyotrophic lateral sclerosis (ALS). Participants the first-in-human trial of intra-spinal allogeneic stem cell therapy for ALS received immunosuppression, and one participant saw dramatic improvement across multiple outcome measures. The primary objective this study (NCT01884571) was assess rate clinical response same immunosuppressive regimen using basiliximab, tacrolimus, mycophenolate, prednisone people with ALS. A defined...
This prospective 12-week open-label trial evaluates the tolerability and efficacy of memantine hydrochloride for treatment core social cognitive deficits in adults with high-functioning autism spectrum disorder (ASD). Measures assessment therapeutic response included Social Responsiveness Scale-Adult Research Version (SRS-A), disorder-specific Clinical Global Impression scales, Behavior Rating Inventory Executive Functioning-Adult Self-Report, Diagnostic Analysis Nonverbal Accuracy Scale,...
To test the safety, tolerability, and urate-elevating capability of urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS).
Higher urate levels are associated with improved ALS survival in retrospective studies, however whether raising confers a advantage is unknown. In the Safety of Urate Elevation Amyotrophic Lateral Sclerosis (SURE-ALS) trial, inosine raised serum and was safe well-tolerated. The SURE-ALS2 trial designed to assess longer term safety. Functional outcomes smartphone application were also explored.Participants randomized 2:1 (n = 14) or placebo 9) for 20 weeks, titrated 7-8 mg/dL. Primary safety...