Tanayott Thaweethai
A5006567116- Long-Term Effects of COVID-19
- Gestational Diabetes Research and Management
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- COVID-19 and Mental Health
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infant Development and Preterm Care
- Bariatric Surgery and Outcomes
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Thermal Regulation in Medicine
- Vitamin C and Antioxidants Research
- Respiratory Support and Mechanisms
- Genetic Associations and Epidemiology
- Advanced Causal Inference Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience of respiration and sleep
Massachusetts General Hospital
2021-2025
Harvard University
2021-2025
Somerville Hospital
2025
Lemuel Shattuck Hospital
2025
Harvard Pilgrim Health Care
2023
Brigham and Women's Hospital
2023
Broad Institute
2023
University of South Florida
2023
Brown University
2016-2023
Acumen (United States)
2015
Importance SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms other health effects occurring after acute infection, termed postacute sequelae of (PASC), also known as long COVID . Characterizing PASC requires analysis prospectively and uniformly collected data from diverse uninfected infected individuals. Objective To develop a definition using self-reported describe frequencies across cohorts, vaccination status, number infections. Design, Setting, Participants...
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
Importance A substantial number of individuals worldwide experience long COVID, or post-COVID condition. Other postviral and autoimmune conditions have a female predominance, but whether the same is true for especially within different subgroups, uncertain. Objective To evaluate sex differences in risk developing COVID among adults with SARS-CoV-2 infection. Design, Setting, Participants This cohort study used data from National Institutes Health (NIH) Researching to Enhance Recovery...
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms other health effects after the acute phase of infection; termed post-acute sequelae (PASC), long COVID. The characteristics, prevalence, trajectory and mechanisms PASC are ill-defined. objectives Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study Adults (RECOVER-Adult) to: (1) characterize prevalence; (2) symptoms, organ dysfunction, natural history, distinct phenotypes PASC; (3)...
Abstract Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods the impact preexisting on probable PASC in adults and children using electronic health record data from multiple research networks. Three networks within REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, National Cohort...
There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).
To evaluate changes in insulin physiology euglycemic pregnancy and gestational diabetes mellitus (GDM).Participants underwent oral glucose tolerance tests at ≤15 weeks' gestation (early pregnancy), 24-32 (mid-late 6-24 weeks postpartum. We evaluated longitudinal secretory response (log Stumvoll first-phase estimate) sensitivity Matsuda index) using linear mixed models. then participants who met GDM criteria early GDM) mid-late (classic separately from those without GDM. derived the (PIP)...
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity condition. Iterative refinement classification index for research is needed to incorporate newly available data as field rapidly evolves. Objective To update 2023 adults LC using additional participant from Researching Enhance Recovery (RECOVER-Adult) study an expanded symptom list based on input patient communities. Design, Setting, Participants Prospective,...
Obesity is a strong risk factor for adverse outcomes in patients hospitalized with COVID-19, however, the distribution of fat and amount muscle mass are more accurate factors than BMI. The objective this study was to assess body composition measures obtained on opportunistic abdominal CTs as predictors outcome COVID-19. We hypothesized that elevated visceral intermuscular adipose tissue would be associated outcome.Our retrospective IRB-approved HIPAA-compliant. group comprised 124 (median...
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...
OBJECTIVE Pregnant individuals are universally screened for gestational diabetes mellitus (GDM). Gestational glucose intolerance (GGI) (an abnormal initial GDM screening test without a diagnosis) is not recognized risk factor. We tested an association between GGI and after pregnancy. RESEARCH DESIGN AND METHODS conducted retrospective cohort study of followed prenatal primary care. defined as glucose-loading result at ≥24 weeks’ gestation with oral tolerance (OGTT) that did meet criteria....
Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established. Our objectives were (1) to gestational age-specific reference intervals for CBCs and their a large United States-based cohort (2) use these examine associations between extreme values risk of obstetric complications. Retrospective study including electronic health record-based discovery validation cohorts....
Identifying individuals hospitalized for SARS-CoV-2 infection at increased risk of death is crucial clinical decision making. Analyses must consider simultaneously the multitude biomarkers across several domains and how these biomarker profiles change over time. This electronic health records-based study included a Massachusetts General Brigham hospital least 24 h within 5 days prior 30 after diagnosis COVID-19. K-means clustering was used to identify among 20 eligible proportional hazards...
Obesity is an established risk factor for severe COVID-19 outcomes. The mechanistic underpinnings of this association are not well-understood.
Statins may be protective in severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection. The aim of the current study was to evaluate effect in-hospital statin use on 28-day mortality rates and intensive care unit (ICU) admission among patients with SARS-CoV-2, stratified into 4 groups: those who used statins before hospitalization (treatment continued or discontinued hospital) did not newly initiated hospital never initiated).In a cohort 1179 record review assess demographics,...
Hospital-based biobanks are being increasingly considered as a resource for translating polygenic risk scores (PRS) into clinical practice. However, since these originate from patient populations, there is possibility of bias in estimation due to overrepresentation patients with higher frequency healthcare interactions.PRS schizophrenia, bipolar disorder, and depression were calculated using summary statistics the largest available genomic studies sample 24 153 European ancestry participants...
Pregnancy induces unique physiologic changes to the immune response and hormonal leading plausible differences in risk of developing post-acute sequelae SARS-CoV-2 (PASC), or Long COVID. Exposure during pregnancy may also have long-term ramifications for exposed offspring, it is critical evaluate health outcomes children. The National Institutes Health (NIH) Researching COVID Enhance Recovery (RECOVER) Multi-site Observational Study PASC aims infection various populations. RECOVER-Pregnancy...
To examine the relationship between gestational glucose intolerance (GGI) and neonatal hypoglycemia.
To evaluate the risks of large-for-gestational-age birth weight (LGA) and weight-related complications in pregnant individuals with gestational glucose intolerance, an abnormal screening loading test result without meeting diabetes mellitus (GDM) criteria.
Clinical trial participation should theoretically reduce barriers to care by ensuring medication and healthcare access. We aimed evaluate disparities in achieving diabetes treatment targets race/ethnicity educational attainment within the Action Control Cardiovascular Risk Diabetes (ACCORD) (ClinicalTrials.gov NCT00000620). The ACCORD included three interventions of varying participant burden: glycaemic (high burden), blood pressure (medium burden) triglyceride-lowering (low burden)....