A5043522297- Palliative Care and End-of-Life Issues
- Family and Patient Care in Intensive Care Units
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in medical practice
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Patient Dignity and Privacy
- Healthcare Policy and Management
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Neutropenia and Cancer Infections
- Child and Adolescent Psychosocial and Emotional Development
- Heart Failure Treatment and Management
- Geriatric Care and Nursing Homes
- Obsessive-Compulsive Spectrum Disorders
- Reflective Practices in Education
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 detection and testing
- Medical Malpractice and Liability Issues
- Thermal Regulation in Medicine
- Regulation of Appetite and Obesity
Cedars-Sinai Medical Center
2022-2024
University of Washington
2017-2022
Lung Institute
2022
Harborview Medical Center
2020
Apple (United Kingdom)
2017
Columbia University
2013
St. Mary's Hospital
1993
In mid-December 2021, the B.1.1.529 (Omicron) variant of SARS-CoV-2, virus that causes COVID-19, surpassed B.1.617.2 (Delta) as predominant strain in California.§ Initial reports suggest Omicron is more transmissible and resistant to vaccine neutralization but less severe illness compared with previous variants (1-3). To describe characteristics patients hospitalized SARS-CoV-2 infection during periods Delta predominance, clinical outcomes were retrospectively abstracted from electronic...
Patients with chronic illness frequently use Physician Orders for Life-Sustaining Treatment (POLST) to document treatment limitations.To evaluate the association between POLST order medical interventions and intensive care unit (ICU) admission patients hospitalized near end of life.Retrospective cohort study POLSTs who died January 1, 2010, December 31, 2017, were 6 months or less before death in a 2-hospital academic health system.POLST ("comfort measures only" vs "limited additional...
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity condition. Iterative refinement classification index for research is needed to incorporate newly available data as field rapidly evolves. Objective To update 2023 adults LC using additional participant from Researching Enhance Recovery (RECOVER-Adult) study an expanded symptom list based on input patient communities. Design, Setting, Participants Prospective,...
Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition agouti-related protein (AgRP) regulates food intake and energy expenditure can modulate neuroendocrine responses to changes in balance. To examine the effects AgRP on balance, a small molecule, non-peptide compound, TTP2515, developed TransTech Pharma, Inc., was studied vitro rodent models vivo. TTP2515 prevented from antagonizing α-MSH-induced increases cAMP HEK 293 cells...
Initial reports suggest the B.1.1.529 (Omicron) variant of SARS-CoV-2 causes less severe disease compared with B.1.617.2 (Delta) variant, though more widespread vaccination contributed to these findings. Little is known about clinical characteristics and outcomes patients infection requiring intensive care during periods Delta Omicron predominance.To examine compare critically ill adults predominance.We conducted a retrospective cohort study at one academic hospital in Los Angeles (15 July...
BACKGROUND/OBJECTIVES Many older persons with chronic illness use Physician Orders for Life‐Sustaining Treatment (POLST) to document portable medical orders emergency care. However, some POLSTs contain combinations of that do not translate into a cohesive care plan (eg, cardiopulmonary resuscitation [CPR] without intensive care, or antibiotics). This study characterizes the prevalence and predictors conflicting orders. DESIGN Retrospective cohort study. SETTING Large academic health system....
BACKGROUND Identifying hospitals that are both early and consistent adopters of high‐value care can help shed light on the culture practices at those institutions necessary to promote nationwide. The use troponin diagnose acute myocardial infarction (AMI), not test for myoglobin or creatine kinase‐MB (CK‐MB), is a recommendation Choosing Wisely ® campaign. OBJECTIVE To examine variation in cardiac biomarker testing effect troponin‐only diagnosis AMI. DESIGN A retrospective observational...
SARS-CoV-2 vaccines have unquestionably blunted the overall impact of COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy population healthcare workers (CORALE study cohort) who had unexpectedly low peak anti-spike receptor binding domain (S-RBD) antibody levels after receiving BNT162b2 vaccine. Compared to matched controls, "low responders" fewer spike-specific...
A leading cause of mortality after influenza infection is the development a secondary bacterial pneumonia. In absence superinfection, prescribing antibacterial therapies not indicated but has become common clinical practice for those presenting with respiratory viral illness. murine model, we found that antibiotic use during impaired lung innate immunologic defenses toward challenge methicillin-resistant Staphylococcus aureus (MRSA). Antibiotics augment eosinophils, which have inhibitory...