A5022318132- Immune cells in cancer
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
- Cardiovascular Disease and Adiposity
- Complement system in diseases
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
Cedars-Sinai Medical Center
2021-2024
University of California, Los Angeles
2023
Abstract Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury infection. During aging they undergo functional changes, but underlying mechanisms their contributions neuroprotection versus neurodegeneration are unclear. Previous studies suggested that microglia sex dimorphic, so we compared microglial in mice of both sexes. RNA-sequencing hippocampal revealed more aging-associated changes female than male microglia, differences old young microglia....
Abstract Aging is associated with increased monocyte production and altered function. Classical monocytes are heterogenous a shift in their subset composition may underlie some of apparent functional changes during aging. We have previously shown that mouse granulocyte‐monocyte progenitors (GMPs) produce “neutrophil‐like” (NeuMo), whereas monocyte‐dendritic cell (MDPs) monocyte‐derived dendritic (moDC)‐producing (DCMo). Here, we demonstrate classical from the bone marrow old male female mice...
Abstract The processes that govern human haematopoietic stem cell (HSC) self-renewal and engraftment are poorly understood challenging to recapitulate in culture reliably expand functional HSCs 1–3 . Here we identify MYC target 1 (MYCT1; also known as MTLC) a crucial HSC regulator moderates endocytosis environmental sensing HSCs. MYCT1 is selectively expressed undifferentiated progenitor cells (HSPCs) endothelial but becomes markedly downregulated during culture. Lentivirus-mediated...
SARS-CoV-2 vaccines have unquestionably blunted the overall impact of COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy population healthcare workers (CORALE study cohort) who had unexpectedly low peak anti-spike receptor binding domain (S-RBD) antibody levels after receiving BNT162b2 vaccine. Compared to matched controls, "low responders" fewer spike-specific...
Background: Hematopoietic stem cells (HSC) integrate diverse environmental cues to maintain the balance between quiescence, self-renewal and differentiation throughout life. However, molecular programs governing HSC stemness become dysregulated during culture, compromising engraftment ability. Despite recent advances in optimizing culture conditions for human HSC, our ability expand or modify functional HSCs therapeutic use is still limited. Our data uncovered MYCT1 (Myc target 1) as a...
Abstract Monocytes can patrol the circulation or be recruited into tissues to become macrophages monocyte-derived dendritic cells (moDCs). We previously showed that monocytes arise via two independent pathways in mouse bone marrow: Granulocyte-Monocyte Progenitors (GMPs) produce neutrophils and monocytes, Monocyte-DC (MDPs) yield conventional plasmacytoid DCs (cDCs pDCs). Notably, both differentiate macrophages, but moDCs exclusively MDP pathway. also microbial stimuli LPS CpG promote...