A5016225955- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- SARS-CoV-2 and COVID-19 Research
- Cardiac Health and Mental Health
- Health disparities and outcomes
- T-cell and B-cell Immunology
- Maternal Mental Health During Pregnancy and Postpartum
- Dementia and Cognitive Impairment Research
- Cardiovascular Syncope and Autonomic Disorders
- Reproductive Health and Contraception
- Climate Change and Health Impacts
- Intensive Care Unit Cognitive Disorders
- Maternal and Perinatal Health Interventions
- Hepatitis B Virus Studies
- COVID-19 and healthcare impacts
- Bipolar Disorder and Treatment
- HIV, Drug Use, Sexual Risk
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Telemedicine and Telehealth Implementation
- Food Security and Health in Diverse Populations
- Non-Invasive Vital Sign Monitoring
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
Cedars-Sinai Medical Center
2021-2024
Cedars-Sinai Smidt Heart Institute
2021-2024
University of Washington
2020-2022
Seattle University
2022
Start Treatment & Recovery Centers
2020
University of New England
2014
Objectives We sought to understand the demographic and clinical factors associated with variations in longitudinal antibody response following completion of two-dose regiment BNT162b2 vaccination. Design This study is a 10-month cohort healthcare workers serially measured anti-spike protein IgG (IgG-S) levels using mixed linear models examine their associations participant characteristics. Setting A large, multisite academic medical centre Southern California, USA. Participants total 843 met...
Abstract Blood pressure variability (BPV) and heart rate (HRV) have been associated with Alzheimer’s Disease Related Dementias (ADRD) in rigorously controlled studies. However, the extent to which BPV HRV may offer predictive information real-world, routine clinical care is unclear. In a retrospective cohort study of 48,204 adults (age 54.9 ± 17.5 years, 60% female) receiving continuous at single center, we derived from routinely collected data. We use multivariable Cox models evaluate...
This paper presents a suite of simplified soil water and solute monitoring tools that give output as colours, which are thresholds for action. Data is presented colour patterns, highlight dynamics, such under over irrigation, nitrate leaching salt accumulation. Colour universal language connects the knowledge domains scientists farmers into unified learning system. Evidence from field shows smallholder using these can interpret leading to increased yields, savings in reduction conflict on...
Individual-level blood pressure (BP) variability, independent of mean BP levels, has been associated with increased risk for cardiovascular events in cohort studies and clinical trials using standardized measurements. The extent to which variability relates the real-world practice setting is unclear. We sought determine if adverse outcomes clinically generated data from electronic health record (EHR).
Abstract Background Individuals with post-acute sequelae of COVID (PASC) may have a persistence in immune activation that differentiates them from individuals who recovered without clinical sequelae. To investigate how humoral vary this regard, we compared patterns vaccine-provoked serological response patients PASC to prior PASC. Methods We prospectively studied 245 adults clinically diagnosed and 86 successfully COVID. All participants had measures immunity SARS-CoV-2 assayed before or...
Objective: Comorbidity between anxiety and cannabis use is common yet the nature of association these conditions not clear. Four theories were assessed, a fifth hypothesis tested to determine if misattribution stress symptomology plays role in state-anxiety cannabis. Methods: Three-hundred-sixteen participants ranging age from 18-71 years completed short online questionnaire asking about their history symptoms anxiety. Results: Past current users reported higher incidence lifetime than who...
Abstract Background Seasonal and regional surges in COVID-19 have imposed substantial strain on healthcare systems. Whereas sharp inclines hospital volume were accompanied by overt increases case fatality rates during the very early phases of pandemic, relative impact later pandemic are less clear. We sought to characterize how 2020 winter surge volumes impacted an adequately-resourced health system. Methods performed a retrospective cohort study all adult diagnosed with large academic...
Background Exercise‐based cardiac rehabilitation (CR) is known to reduce morbidity and mortality for patients with conditions. Sociodemographic disparities in accessing CR persist could be related the distance between where live facilities are located. Our objective determine association sociodemographic characteristics geographic proximity facilities. Methods Results We identified actively operating across Los Angeles County used multivariable Poisson regression examine of residential...
To assess the extent of unwanted abortion disclosure and levels social support in decision their association with depression, anxiety, stress.From January to June 2019, we surveyed people presenting for at four clinics California, New Mexico, Illinois regarding experiences accessing abortion. We used multivariable regression examine associations between decision, symptoms anxiety stress.Among 1092 approached, 784 (72% response rate) eligible individuals initiated survey, 746 responded item...
Background Despite recent improvements in hypertension control overall, the extent to which these trends apply most extreme forms of elevated blood pressure—hypertensive crises requiring hospitalization—in both women and men at risk remains unknown. Methods Results Using data from National Inpatient Sample, we estimated sex‐pooled sex‐specific temporal hypertensive crisis hospitalization case fatality rates over serial time periods: years 2002 2006, 2007 2011, 2012 2014. Over entire study...
Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses Pfizer-BioNTech SARS-CoV-2 mRNA vaccine completed post-vaccine...
The impact of high-flow nasal cannula (HFNC) on outcomes patients with respiratory failure from coronavirus disease 2019 (COVID-19) is unknown. We sought to assess whether exposure HFNC before intubation was associated successful extubation and in-hospital mortality compared receiving only.This single-center retrospective study examined COVID-19-related March 2020 2021 who required HFNC, intubation, or both. Data were abstracted the electronic health record. Use duration examined' as well...
SARS-CoV-2 vaccines have unquestionably blunted the overall impact of COVID-19 pandemic, but host factors such as age, sex, obesity, and other co-morbidities can affect vaccine efficacy. We identified individuals in a relatively healthy population healthcare workers (CORALE study cohort) who had unexpectedly low peak anti-spike receptor binding domain (S-RBD) antibody levels after receiving BNT162b2 vaccine. Compared to matched controls, "low responders" fewer spike-specific...
Early reports highlighted racial/ethnic disparities in the severity of COVID-19 seen across USA; extent to which these have persisted over time remains unclear. Our research objective was understand temporal trends variation illness presenting time.We conducted a retrospective cohort analysis using longitudinal data from Cedars-Sinai Medical Center, high-volume health system Southern California. We studied patients admitted hospital with 4 March 2020 through 5 December 2020. primary outcome...
Background and objectives Recognized as a potential risk factor for Alzheimer's disease related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at population level. Granular BPV data are available during acute care hospitalization periods potentially high-risk patients, but the incident ADRD association with measured in this setting is unknown. Our objective was evaluate relation BPV, hospitalization, incidence ADRD....
Hepatic disease is linked to cardiovascular events but the independent association between hepatic and remains unclear, given shared risk factors. This was a retrospective study of consecutive patients with clinical cardiac MRI (CMR) serological marker fibrosis, FIB-4 score, within one year imaging. We assessed relations scores grouped based on prior literature: low (< 1.3), moderate (1.3-3.25), high (>3.25), abnormalities detected by comprehensive CMR into 4 domains: structure (end...
Abstract Background The risk of developing Alzheimer’s Disease and Related Dementias (ADRD) is associated with visit‐to‐visit blood pressure (BP) variability, including variability independent the mean (VIM). 1,2 association between ADRD VIM has primarily been evaluated using standardized BP measurements from clinical trials cohorts, rather than utilizing practice, potentially limiting generalizability to real‐world context. As such, we sought evaluate relationship data collected electronic...