A5064521144- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Cardiovascular Issues in Pregnancy
- Liver Disease and Transplantation
- Mechanical Circulatory Support Devices
- Liver Disease Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Renal and Vascular Pathologies
- Aortic Thrombus and Embolism
- Kawasaki Disease and Coronary Complications
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Organ Donation and Transplantation
Cedars-Sinai Smidt Heart Institute
2020-2025
Cedars-Sinai Medical Center
2019-2025
Texas A&M University
2024
Columbia University Irving Medical Center
2023
West Virginia University
2021
Palo Alto University
2019
Stanford University
2019
Lucile Packard Children's Hospital
2018
Stanford Health Care
2018
NYU Langone Health
2016
Summary During development, the ventricular conduction system (VCS) arises from trabecular or spongy myocardium. VCS and myocytes proliferate at a significantly slower rate than compact zone myocardial cells, establishing transmural cell cycle gradient. The molecular determinants of VCS/trabecular myocyte arrest are not known. Given importance pocket proteins (Rb, p107 p130) in mediating G0/G1 many types, we examined role this gene family regulating exit myocardium system. Using...
Consideration of thrombolysis as first-line reperfusion therapy in patients with COVID-19 and STEMI is recommended by ACC/SCAI guidelines. We describe a patient COVID-19, who presented ST-elevation myocardial infarction was treated anticoagulation. He later found to have significant persistent thrombus burden requiring thrombectomy stent placement. Invasive hemodynamics on multiple high-dose pressers revealed high cardiac output state low systemic vascular resistance, consistent distributive...
Coronary artery fistula (CAF) is an abnormal connection between a coronary and heart chamber resulting in left-to-right shunt. A large CAF was unexpected cause of failure 58-year-old woman who underwent transcatheter closure the with improvement symptoms but complicated by myocardial infarction. (Level Difficulty: Beginner.)
Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses Pfizer-BioNTech SARS-CoV-2 mRNA vaccine completed post-vaccine...
Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. The purpose this study was investigate the prevalence risk factors for COVID-19 TE/bleeding complications in ACHD patients. COVID-19-positive were included between May 2020 November 2021. TE events ischemic cerebrovascular accident, systemic pulmonary embolism, deep venous thrombosis, myocardial infarction, intracardiac...
Adults with congenital heart disease (ACHD) may undergo transplantation (HTx) despite increased risk of poor short-term outcomes due to factors including surgical complexity and antibody sensitization. We assessed the clinical characteristics patients ACHD in current era referred for HTx at a single high-volume transplant center.From 2010 2020, 37 were evaluated HTx. recipients compared non-ACHD matched age, sex, listing status, prior cardiac surgery.Of ACHD, eight (21.6%) declined Of 29...
Despite advancements in mechanical circulatory support (MCS) technology, persistent critical complications related to blood contact remain unresolved. To provide a safer alternative therapy, CorInnova is developing non-blood contacting direct cardiac compression (DCC) device for MCS. product development toward clinical trials, simulation platform has been developed predict outcomes under patient-specific conditions, guiding patient selection trials. The Harvi was validated using preclinical...
Giant cell myocarditis is a rare and often fatal disease. The most obvious presentation described in the literature one of rapid hemodynamic deterioration due to cardiogenic shock necessitating urgent consideration mechanical circulatory support heart transplantation. We present case 60-year-old man whose initial was consistent with myopericarditis but who went on develop decline left ventricular systolic function without overt compromise or dramatic symptomatology. confirmed via...
Abstract Background: While abnormalities of liver function and imaging are common in patients with end-stage heart failure, advanced fibrosis is uncommon. Liver biopsy (LB) used to identify transplant (HT) candidates but can delay or limit access definitive therapies cause complications. We sought develop determine the utility a clinical risk score for HT candidates. Methods: conducted retrospective, single-center review evaluated between 2012 2019 (n = 1,651) identified those who underwent...
While abnormalities of liver function and imaging are common in patients with end-stage heart failure, advanced fibrosis is uncommon. Liver biopsy (LB) used to identify transplant (HT) candidates but can delay or limit access definitive therapies cause complications. We sought develop determine the utility a clinical risk score for HT candidates. conducted retrospective, single-center review evaluated between 2012 2019 (n = 1,651) identified those who underwent LB 137) as well matched...