A5050585132- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Vascular anomalies and interventions
- Liver Disease and Transplantation
- Aortic Disease and Treatment Approaches
- Cardiovascular and Diving-Related Complications
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Heart Rate Variability and Autonomic Control
- Frailty in Older Adults
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Eicosanoids and Hypertension Pharmacology
- Renal Transplantation Outcomes and Treatments
Johns Hopkins Hospital
2020-2025
Johns Hopkins University
2020-2025
GTx (United States)
2024
Johns Hopkins Medicine
2020-2024
University of Gothenburg
2024
Baylor University Medical Center
2016-2023
Johns Hopkins Children's Center
2021-2023
Boston Children's Hospital
2016-2023
Children's Hospital of Philadelphia
2023
Brigham and Women's Hospital
2023
Diurnal variation of cardiac function in vivo has been attributed primarily to changes factors such as sympathetic activity. No study investigated previously the intrinsic properties heart throughout day. We therefore diurnal variations metabolic flux and contractile isolated working rat how this related circadian expression genes. Contractile performance, carbohydrate oxidation, oxygen consumption were greatest middle night, with little fatty acid oxidation. The all genes (including...
Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in maintenance membrane structure function, thereby fundamentally integrating dynamic alterations myocardial performance with composition dynamics. The major phospholipases myocardium belong to a family known as calcium-independent (iPLA2s). In addition their role maintaining normal iPLA2 catalytic activity results generation...
There is significant interest in NO pathway modulators, specifically type 5 phosphodiesterase inhibitors (PDE5is), to treat patients with a Fontan circulation. Trials, however, have had mixed results. The relationship between the and clinical status circulation knowledge gap. We performed targeted metabolomic analysis using liquid chromatography coupled mass spectrometry quantify plasma metabolite concentrations from 2 well-characterized populations of circulation: Boston Adult Congenital...
Objective Obesity affects adults with congenital heart disease (CHD). The effect of an increased body mass index (BMI) respect to morbidity and mortality has not been evaluated in complex CHD. Our objective was evaluate the effects BMI on failure univentricular patients who had undergone Fontan palliation. Methods A query patients' first appointments at Washington University Center for Adults CHD between 2007 2014 yielded 79 patients. status as normal (<25 kg/m2), overweight (≥25, <30 obese...