A5063727362- Congenital Heart Disease Studies
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Connective tissue disorders research
- Cardiac pacing and defibrillation studies
- Cardiovascular Issues in Pregnancy
- Ultrasound in Clinical Applications
- Tracheal and airway disorders
- Proteoglycans and glycosaminoglycans research
- Mechanical Circulatory Support Devices
- Congenital Diaphragmatic Hernia Studies
- Phonocardiography and Auscultation Techniques
- Pulmonary Hypertension Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Tissue Engineering and Regenerative Medicine
- Obstructive Sleep Apnea Research
- Vascular anomalies and interventions
- Cardiovascular and Diving-Related Complications
University of Arizona
2016-2025
Banner - University Medical Center Tucson
2007-2023
Stanford University
2021
Children's Medical Center
2019
Henry Ford Hospital
2018
Temple University
2018
University of Pennsylvania
2018
Hospital Universitari Germans Trias i Pujol
2018
Children's Center
2010
Arizona Science Center
2006
We identified hyaluronan synthase-2 (Has2) as a likely source of (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2–/– embryos lack HA, exhibit severe cardiac vascular abnormalities, die midgestation (E9.5–10). Heart explants from the characteristic transformation endothelial cells into mesenchyme, an essential developmental event that depends on receptor-mediated intracellular signaling. This defect is reproduced by expression dominant-negative...
ABSTRACT Background Almost half of individuals born with Down syndrome (DS) have congenital heart defects (CHDs). Yet, little is known about the health and healthcare needs adults CHDs DS. Therefore, we examined comorbidities utilization this population. Methods Data were from 2016–2019 Congenital Heart Survey to Recognize Outcomes, Needs, well‐beinG (CH STRONG), a survey 19–38‐year‐olds identified through birth registries in Arkansas, Arizona, Atlanta. Outcome estimates standardized CH...
Limited population-based information is available on long-term survival of US individuals with congenital heart defects (CHDs). Therefore, we assessed patterns in from birth until young adulthood (ie, 35 years age) and associated factors among a sample CHDs.
Total anomalous pulmonary venous return (TAPVR) is a congenital heart defect inherited via complex genetic and/or environmental factors. We report detailed mapping in extended TAPVR kindreds and mutation analysis patients that implicate the PDGFRA gene development of TAPVR. Gene expression studies mouse chick embryos for both Pdgfra receptor its ligand Pdgf-a show temporal spatial patterns consistent with role vein (PV) development. used an ovo function blocking assay conditional knockout...
Transition from adolescence to adulthood is a change in status yielding self-sufficiency, independence, and participation adult roles. There are numerous efforts define transition elements encourage formalized processes readying youth for adulthood, yet significant challenges remain. We recruited individuals who were age 12 years or older not transitioned 18 within 24 months complete questionnaires participate focus group. 25 participants (Mean 17.9 years) completed 76 % participated groups....
The mouse p locus encodes a gene that functions in normal pigmentation. We have characterized radiation-induced mutant allele of the is associated with failure-to-thrive syndrome, addition to diminished Mice homozygous for this allele, 100H , show delayed growth and die within 2 wk after birth. discovered mice develop progressive atrioventricular heart block significant ultrastructural changes both cardiac skeletal muscle cells. These observations are common characteristics described human...
Abstract The role played by specific extracellular matrix molecules in normal endocardial cushion differentiation into valves and septa remains to be established. In this respect, type collagen VI is of particular interest because genes encoding the α1 α2 chains are located on chromosome 21, defects involving atrioventricular (AV) cushions frequent trisomy 21. Collagen expression was studied human embryonic fetal hearts (5–18 weeks development) compared immunohistochemistry with results from...
During development, the embryonic atrioventricular (AV) endocardial cushions undergo a morphogenic process to form mature valve leaflets and membranous septa in heart. Several extracellular matrix (ECM) proteins are expressed developing AV cushions, but it remains be established if any specific ECM necessary for normal cushion morphogenesis. Abnormal development of cardiac valves is frequent cause congenital heart defects, particularly infants with trisomy 21 (Down syndrome). The genes...
The aim of the current study is to investigate hospitalization outcomes COVID-19 positive children and adults with moderate or severe congenital heart disease without disease. Retrospective review using Vizient Clinical Data Base for admissions patients an ICD-10 code from April 2020 March 2021. Admissions (CHD) were stratified into pediatric (< 18 years) adult (≥ hospital compared. There 9478 admissions, 160 (1.7%) CHD, 658,230 389 (0.06%) CHD. Pediatric CHD younger (1 vs 11 years), had...
Background Disabilities have implications for health, well-being, and health care, yet limited information is available on the percentage of adults with congenital heart defects (CHD) living disabilities. We evaluated prevalence disability associated characteristics among 2016-2019 CH STRONG (Congenital Heart Survey to Recognize Outcomes, Needs, Well-Being) population-based sample 19- 38-year-olds CHD from 3 US locations. Methods Results Prevalence types (hearing, vision, cognition,...
Abstract Although hypoxic and/or nutritional insults during gestation are believed to contribute congenital heart defects, the mechanisms responsible for these anomalies not understood. Given role vascular endothelial growth factor (VEGF) plays in response hypoxia, it is a likely candidate mediating deleterious effects of embryonic hypoxia. The ectopic or overproduction endogenous factors such as VEGF may specific defects. Here we compared hypoxia‐induced precocious production early valve...
Abstract Endothelial cells in the atrioventricular canal of heart undergo an epithelial‐mesenchymal transition (EMT) to form valves. We surveyed on‐line database ( http://www.geisha.arizona.edu/ ) for clones expressed during gastrulation identify novel EMT components. One gene, latrophilin‐2, was identified as and appeared be functional EMT. This molecule chosen further examination. In situ localization showed it both myocardium endothelium. Several antisense DNA probes siRNA latrophilin‐2...
Pharmacokinetic and pharmacodynamic data on adrenergic agents in children have revealed wide ranges of plasma clearance rates hemodynamic responses patients with critical illnesses or myocardial dysfunction. In order to more clearly elucidate the underlying pharmacologic processes, graded i.v. dobutamine infusions 0.5, 2.5 5.0 micrograms/kg/min were sequentially administered healthy adolescents. Plasma concentrations responses, including echocardiographic measures systolic diastolic...