A5079292680- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Cardiac pacing and defibrillation studies
- Cardiovascular and Diving-Related Complications
- Transplantation: Methods and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Vascular Anomalies and Treatments
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Connective tissue disorders research
- Mechanical Circulatory Support Devices
- Liver Disease and Transplantation
- Aortic aneurysm repair treatments
- Vascular anomalies and interventions
- Hepatocellular Carcinoma Treatment and Prognosis
- Obstructive Sleep Apnea Research
- Cervical Cancer and HPV Research
Children's Hospital of Wisconsin
2016-2025
Medical College of Wisconsin
2014-2023
Children's Hospital of Philadelphia
2023
Hospital of the University of Pennsylvania
2023
Barro Colorado Island
2022
Wisconsin Heart Hospital
2020
Children's Healthcare of Atlanta
2015
Mayo Clinic in Arizona
2015
Pediatrics and Genetics
2012
University of Illinois Chicago
2000
The Fontan operation creates a total cavopulmonary connection, circulation in which the importance of pulmonary vascular resistance is magnified. Over time, this leads to deterioration cardiovascular efficiency associated with decline exercise performance. Rigorous clinical trials aimed at improving physiology and guiding pharmacotherapy are lacking.
Abstract Aims The Fontan operation has resulted in improved survival patients with single‐ventricle congenital heart disease. As a result, there is growing population of teenagers and adults circulation. Many co‐morbidities have been increasingly recognized this due to the unique features Standardization how co‐morbid conditions are defined will help facilitate understanding, consistency interpretability research clinical experience. Unifying common language usage critical precursor step for...
Background/Objectives Following repair of congenital heart disease (CHD), adult patients are at risk for reduced exercise capacity. Restrictive lung (RLD) may contribute to capacity in this population. The aim study was determine the prevalence RLD and its impact on tolerance with CHD. Methods One hundred consecutive CHD, who underwent routine cardiopulmonary testing spirometry, were evaluated. Clinical data obtained by retrospective chart review. Results Patients from 10 major diagnostic...
Objective Patients after Fontan operation for complex congenital heart disease (CHD) have decreased exercise capacity and report reduced health-related quality of life (HRQOL). Studies suggest hospital-based cardiac physical activity programs can improve HRQOL in patients with CHD; however, these variable adherence rates. The impact a home-based program survivors is unclear. This pilot study evaluated the safety, feasibility, benefits an innovative on patients. Methods A total 14 children,...
Background and AimsFor patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated progression to end-stage congestive heart failure (CHF) remain largely unclear.
Introduction An increasing number of patients with congenital heart disease are now surviving into adulthood. This has also led to the emergence complications from underlying disease, related surgical interventions, and associated combordities. While prevalence particular arrhythmias specific been previously described, a detailed analysis all lesions large comorbidities not published. Methods Admissions were identified in National Inpatient Sample. Associated for these patients. Univariate...
Recent data indicate that patients after the Fontan procedure are at risk for significant liver dysfunction; however, prevalence and extent of disease in population remains unknown. Furthermore, limited exist regard to screening adult patients. We sought determine following using computed tomography (CT) serum biomarkers fibrosis. Adult underwent as part their annual evaluation. Screening consisted laboratory evaluation dual-phase CT scan. Laboratory included analysis function, viral...
Background:Cardiac Resynchronization Therapy(CRT) is a key treatment for heart failure(HF) in acquired disease, but its benefits adults with congenital disease and systemic right ventricle(sRV) remain unclear. This study aimed to assess whether CRT improves outcomes patients sRV. Methods:This analysis was part of an international, retrospective data from 33 centers including patients>18years transposition the great arteries(TGA) following atrial switch operation congenitally corrected...
Immune activation results in the of adrenal steroidogenesis and inhibition gonadal steroidogenesis. Previous studies indicated that these effects were caused primarily by suppression secretion ACTH LH, respectively. However, other evidence a direct effect immune system on gonads. In this study, serum testosterone, quantitated RIA after lipopolysaccharide injection, showed significant decrease within 2 h. Parallel measurement LH no change. There differences receptor or cAMP produced Leydig...
Utilization of Fontan fenestration varies considerably by center. Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use impact on post-Fontan length stay (LOS). Patients 2 to 6 years old at surgery from 2010 2020 catheterization <1 year prior were included. Factors using multivariable logistic regression adjusting for key covariates. Restrictive cubic spline analysis was used evaluate...
Abstract The Fontan Outcomes Network was created to improve outcomes for children and adults with single ventricle CHD living circulation. network mission is optimise longevity quality of life by improving physical health, neurodevelopmental outcomes, resilience, emotional health these individuals their families. This manuscript describes the systematic design this new learning network, including initial steps in development a national, lifespan registry, pilot testing data collection forms...