A5080002084- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Muscle Physiology and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Risk Factors
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Geological and Geophysical Studies
- Pulmonary Hypertension Research and Treatments
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Coronary Artery Anomalies
- Respiratory Support and Mechanisms
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Hydrocarbon exploration and reservoir analysis
- Neuroscience of respiration and sleep
- Genetic and Kidney Cyst Diseases
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2009-2025
Ludong University
2025
China University of Geosciences (Beijing)
2016-2024
Ministry of Education of the People's Republic of China
2022
Children's Medical Center
2021
University of Cincinnati Medical Center
2021
Ohio Heart & Vascular Center
2021
Nanjing Traditional Chinese Medicine Hospital
2020
National Heart Institute
2020
Background Patients with Duchenne muscular dystrophy exhibit progressive cardiac and skeletal muscle dysfunction. Based on prior data, dysfunction in patients may be influenced by myocardial fibrosis steroid therapy. We examined the longitudinal relationship of ventricular using magnetic resonance a large cohort. Methods Results reviewed 465 serial studies (98 ≥4 studies) for left ejection fraction ( LVEF ) presence late gadolinium enhancement LGE ), marker fibrosis. was modeled examining...
Background The normal rate of subclinical vascular aging from adolescence to young adulthood has not been well‐characterized. We conducted a 5‐year longitudinal study among adolescents with normal‐weight, obesity, and/or type 2 diabetes mellitus examine trajectories early aging. Methods and Results Adolescents (mean [SD] age 17.6 [3.5]; 35.3% male) had either weight (n=141), obesity (n=156), or (n=151) at baseline. Primary metrics used for included measures structure (carotid intima‐media...
Carotid intima-media thickness (IMT) provides a mechanism for detecting early atherosclerosis. Little information is available concerning carotid IMT and the progression of atherosclerosis in adolescents young adults with type 2 diabetes mellitus.We sought to determine factors that contribute changes youth mellitus identify any predictors increased IMT.Demographic, anthropometric, laboratory data imaging were obtained 129 mixed ethnicity, ages 10-23 yr. Associations outcomes risk variables...
<p dir="ltr">Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. Research Design Methods: This study included 1226 individuals (median age initial visit 18 years, 58% female, 53% Non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity...
<p dir="ltr">Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. Research Design Methods: This study included 1226 individuals (median age initial visit 18 years, 58% female, 53% Non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity...
To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. This study included 1,226 individuals (median age at initial visit 18 years; 58% female; 53% non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity carotid femoral, radial, femoral foot, augmentation...
Among the multiple organ disorders caused by severe acute respiratory syndrome coronavirus (SARS-CoV), lung failure following atypical pneumonia is most serious and often fatal event. We hypothesized that two of hydrophilic structural coronoviral proteins (S E) would regulate alveolar fluid clearance decreasing cell surface expression activity amiloride-sensitive epithelial sodium (Na(+)) channels (ENaC), rate-limiting protein in transepithelial Na(+) vectorial transport across distal cells....
Surfactant protein D (SP-D) is an important effector of innate immunity. We have previously shown that SP-D accumulates at sites acute bacterial infection and neutrophil infiltration, a setting associated with the release reactive species such as peroxynitrite. Incubation native or trimeric lectin domains (NCRDs) peroxynitrite resulted in nitration nondisulfide cross-linking. Modifications were blocked by scavengers pH inactivation peroxynitrite, mass spectroscopy confirmed conserved...
Severe obesity is the fastest growing subgroup of in youth.We sought to explore association between severe and subclinical measures cardiac vascular structure function adolescents young adults.This was a cross-sectional comparison 265 adults with (defined as body mass index [BMI] ≥120% 95th percentile) 182 BMI ≥100-119th at tertiary medical center.Noninvasive were assessed.Participants mean age 17.9 years, 62% non-Caucasian, 68% female. Systolic blood pressure, fasting insulin, C-reactive...
Adults with prediabetes are at increased risk to develop cardiovascular disease. Whether in adolescents is associated early markers of disease not known. We sought 1) compare the profiles among and young adults those normal glucose tolerance 2) determine whether independently noninvasive measures arterial thickness stiffness. studied 102 obese youth 139 a cross-sectional study. Prediabetes or diabetes was diagnosed by fasting blood level ≥100 125 mg/dL, 2-hour oral test value ≥140 199...
Utilization of Fontan fenestration varies considerably by center. Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use impact on post-Fontan length stay (LOS). Patients 2 to 6 years old at surgery from 2010 2020 catheterization <1 year prior were included. Factors using multivariable logistic regression adjusting for key covariates. Restrictive cubic spline analysis was used evaluate...
IL-1R-associated kinase (IRAK)-1 is a critical mediator of TLR/IL-1R-induced activation the transcription factor NF-kappaB. We previously described that commonly occurring IRAK-1 variant haplotype, containing amino acid changes from serine to phenylalanine at position 196 and leucine 532, associated with increased NF-kappaB in LPS-stimulated neutrophils patients sepsis-induced acute lung injury also higher mortality more severe clinical outcomes such patients. To investigate underlying...
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants and children worldwide. We wished to determine whether intratracheal administration beta-agonists improved alveolar fluid clearance (AFC) across distal respiratory epithelium RSV-infected mice. Following intranasal infection with RSV strain A2, AFC was measured anesthetized, ventilated BALB/c mice by instillation 5% BSA into dependent lung. found that direct activation protein kinase A forskolin or...
Turner syndrome (TS) carries an increased risk for vascular disease, or vasculopathy.Vasculopathy can be detected in young TS patients.Vasculopathy was prospectively assessed by measuring function and structure patients (n = 49) lean (L) 76) obese (O) controls 52) through noninvasive techniques. Controls were drawn from previously known adolescents who age-matched disease-free.Pulse wave velocity femoral (PWVf), augmentation index (AIx), carotid intima media thickness (cIMT), Young's Elastic...