A5009128263- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Cardiovascular Disease and Adiposity
- Retinal Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Kidney Injury Research
- Heart Rate Variability and Autonomic Control
- Adolescent and Pediatric Healthcare
- Trauma and Emergency Care Studies
- Celiac Disease Research and Management
- Autoimmune Bullous Skin Diseases
- Hormonal Regulation and Hypertension
- Vasculitis and related conditions
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Retinal Imaging and Analysis
University of North Carolina at Chapel Hill
2016-2025
University of Cincinnati
2023
University of Minnesota
2022-2023
Duke Children's Hospital & Health Center
2023
Zero to Three
2023
Creative Commons
2023
Cedars-Sinai Medical Center
2023
Arkana Laboratories
2023
Providence Health Care
2022
Vanderbilt University
2022
<h3>Importance</h3> The burden and determinants of complications comorbidities in contemporary youth-onset diabetes are unknown. <h3>Objective</h3> To determine the prevalence risk factors for related to type 1 vs 2 among teenagers young adults who had been diagnosed with during childhood adolescence. <h3>Design, Setting, Participants</h3> Observational study from 2002 2015 5 US locations, including 2018 participants at younger than 20 years, single outcome measures between 2011 2015....
Despite available interventions, people with type 2 diabetes (T2D) remain at risk of chronic kidney disease (CKD). Finerenone, a potent and selective nonsteroidal mineralocorticoid receptor antagonist, sodium-glucose cotransporter inhibitors (SGLT2is) can reduce both cardiovascular risks in CKD T2D. Here we outline the design study to investigate whether dual therapy finerenone an SGLT2i is superior either agent alone.CONFIDENCE (NCT05254002) randomized, controlled, double-blind,...
Diabetic kidney disease is the most frequent cause of failure, accounting for half all cases worldwide. Moreover, deaths from diabetic increased 106% between 1990 and 2013, with attributed to cardiovascular disease. Recommended screening monitoring are conducted in less than patients diabetes. Standard-of-care treatment an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker correspondingly low. Sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, a...
Abstract The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily 1 , producing a growing public health concern that disproportionately affects minority groups . genetic basis T2D its relationship to other forms are unclear 3 Here we report detailed characterization by analysing exome sequences common variant associations for 3,005 individuals with 9,777 adult control participants matched ancestry, including both males females. We identify monogenic...
To determine the prevalence, progression, and modifiable risk factors associated with development of diabetic retinopathy (DR) in a population-based cohort youth-onset diabetes.
Significance Two common variants in the APOL1 gene explain most of high rate kidney disease people recent African ancestry. However, not all high-risk individuals develop disease. Here we identified UBD locus as a genetic modifier using admixture mapping. Focal segmental glomerulosclerosis patients have significantly increased ancestry at locus, which associates with lower expression. Using cell-based system, show that and interact functionally higher levels expression mitigate -mediated...
Pathogenetic markers of diabetic kidney disease (DKD) progression to ESRD are lacking. We characterized the prognostic value histologic findings in DKD for time native specimens from biopsies performed 1995 2011 with glomerulosclerosis as only glomerular diagnosis (n=109). Biopsy were analyzed according standard methods, including determination nephropathy class, defined by Renal Pathology Society. Clinical data extracted electronic medical records. used competing risk models, death risk,...
Background FSGS is a heterogeneous diagnosis with guarded prognosis. Polymorphisms in the apolipoprotein L1 ( APOL1 ) gene are associated developing and faster progression to kidney failure affected patients. Better understanding natural history of patients risk alleles essential improve patient care support design interpretation interventional studies. The objective this study was evaluate quantitative association between disease interaction other clinical laboratory factors. Methods CureGN...
Finerenone, a selective nonsteroidal MRA, and SGLT2is both reduce CKD progression improve kidney/CV outcomes. The CONFIDENCE study (NCT05254002; EudraCT 2021-003037-11) hypothesis is that early combination of finerenone empagliflozin, SGLT2i, superior to either drug alone in reducing UACR over 6 months. an ongoing, fully enrolled, randomized, controlled, double-blind, multicentre phase 2 clinical trial adults (≥18 years age) with T2D, eGFR 30 90 ml/min/1.73 m2, ≥100 <5000 mg/g. Participants...
<p dir="ltr">Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. Research Design Methods: This study included 1226 individuals (median age initial visit 18 years, 58% female, 53% Non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity...
<p dir="ltr">Objective: To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. Research Design Methods: This study included 1226 individuals (median age initial visit 18 years, 58% female, 53% Non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity...
To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents young adults with youth-onset diabetes. This study included 1,226 individuals (median age at initial visit 18 years; 58% female; 53% non-Hispanic White, 22% Black, 20% Hispanic) type 1 or 2 diabetes from SEARCH for Diabetes Youth Study. Arterial stiffness measures pulse wave velocity carotid femoral, radial, femoral foot, augmentation...
In people with type 2 diabetes, aggressive control of glycemia, BP, and lipids have resulted in conflicting short-term (<5 years) kidney outcomes. We aimed to determine the long-term effects these interventions.