A5053522142- Cystic Fibrosis Research Advances
- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Tracheal and airway disorders
- Cardiovascular Health and Disease Prevention
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Food Security and Health in Diverse Populations
- Diabetes Treatment and Management
- Celiac Disease Research and Management
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pneumocystis jirovecii pneumonia detection and treatment
- Growth Hormone and Insulin-like Growth Factors
- Digestive system and related health
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Genetic and Kidney Cyst Diseases
- Adrenal and Paraganglionic Tumors
University of Washington
2018-2024
Seattle Children's Hospital
2017-2023
Seattle University
2018
Emory University
2014-2015
The development and introduction of modulator therapies have completely shifted the paradigm for treatment cystic fibrosis (CF). Highly effective driven marked improvements in lung function, exacerbation rate, weight quality life CF patients. However, their effect on related diabetes (CFRD) is not well delineated. role transmembrane conductance regulator (CFTR) CFRD pathogenesis inadequately understood research aimed at deciphering underlying mechanisms continues to evolve. In this review,...
Autosomal-recessive mutations in the growth hormone receptor (GHR) are most common causes for primary insensitivity (GHI) syndrome with classical GHI phenotypically characterized by severe short stature and marked insulin-like factor (IGF)-I deficiency. We report three families dominant-negative heterozygous intracellular domain of GHR causing a nonclassical phenotype.To determine if identified variants exert potential effects cause phenotype our patients.All (c.964dupG,...
To examine the association between household food insecurity (HFI), glycemic control, severe hypoglycemia and diabetic ketoacidosis (DKA) among youth young adults (YYA) with youth-onset type 2 diabetes.This cross-sectional study included 395 YYA diabetes from SEARCH for Diabetes in Youth Study (2015-2019). HFI was reported by adult participants or parents of minor via US Household Food Security Survey Module. Glycemic control assessed HbA1c analyzed as a continuous categorical variable...
The role of growth hormone (GH) and its therapeutic supplementation in the trichorhinophalangeal syndrome type I (TRPS I) is not well delineated. TRPS a rare congenital syndrome, characterized by craniofacial skeletal malformations including short stature, sparse, thin scalp hair lateral eyebrows, pear-shaped nose, cone shaped epiphyses hip dysplasia. It inherited an autosomal dominant manner caused haploinsufficiency TRPS1 gene. We report family (Mother 3 her 4 children) with novel mutation...
Eating disorders and disturbed body image have been reported in individuals with cystic fibrosis (CF) may contribute to poor weight gain, reduced lung function increased mortality. CF often look feel different from their peers bear the additional burden of body-altering side effects treatment. As a result, impact such as binge eating, anorexia nervosa, bulimia nervosa adversely affect social, emotional, physical development those CF. Multiple risk factors an eating disorder Growth failure is...
OBJECTIVE To examine short-term mortality and cause of death among youth young adults (YYAs) with youth-onset diabetes. RESEARCH DESIGN AND METHODS We included 19,717 YYAs newly diagnosed diabetes before 20 years age from 1 January 2002 to 31 December 2015 enrolled in the SEARCH for Diabetes Youth Study. Of these, 14,721 had type 1; 4,141 2; 551 secondary 304 other/unknown type. Cases were linked National Death Index through 2017. calculated standardized ratios (SMRs) 95% CIs based on age,...
Our aim was to explore the relationship of Low-Density Lipoprotein Cholesterol (LDL-C) with subclinical cardiovascular disease (CVD) in youth T1D and T2D. We hypothesized association LDL-C elevated arterial stiffness (AS) would be partially accounted by co-occurrence other CVD factors.
Rationale: Pulmonary exacerbation (PEx) events contribute to lung function decline in people with cystic fibrosis (CF). CF Foundation PEx guidelines note that a short course of systemic corticosteroids may offer benefit without contributing long-term adverse effects. However, insufficient evidence exists recommend for treatment. Objectives: To determine if the treatment in-hospital pediatric are associated improved clinical outcomes compared corticosteroids. Methods: We conducted...
Hyperglycaemia may contribute to failure recover from pulmonary exacerbations in cystic fibrosis (CF). We aimed evaluate the prevalence and mechanism of hyperglycaemia during post-exacerbations.
OBJECTIVE To identify correlates of hemoglobin A1c (HbA1c) testing frequency and associations with HbA1c levels microvascular complications in youth-onset diabetes. RESEARCH DESIGN AND METHODS The SEARCH for Diabetes Youth study collected data from individuals diagnosed diabetes before age 20 at 8 years (n = 1,885 type 1, n 230 2) 13 649 84 duration. We identified reporting ≥3 tests/year using logistic regression. examined (retinopathy, neuropathy, or nephropathy) sequentially adjusted...
Objectives . Cardiovascular disease (CVD) is the leading cause of death and disability among persons with diabetes. Early intervention on cardiovascular risk factors (CRFs) important in reducing CVD burden. The SEARCH for Diabetes Youth study assessed CRFs incident cohorts youth aged <20 years established from 2002 to 2016. Research Design Methods Regression models trends over each year lipids (total cholesterol (TC), HDL‐c, LDL‐c, triglycerides (TG), VLDL‐c, non‐HDL‐c), kidney function...
Diabetes is the most common comorbidity in individuals with cystic fibrosis (CF). Among people CF, prevalence of CF-related diabetes (CFRD) estimated to be 2% children, 19% adolescents, 40% their 20s, and 45–50% those ≥30 years age (1). CFRD shares some aspects type 1 that it primarily due insulin deficiency, but distinguished from because its insidious onset over persistence production long after diagnosis, which makes diabetic ketoacidosis (DKA) very rare (2). Routine screening for...
As females with cystic fibrosis (CF) increasingly reach their reproductive years, gynecologic issues have become an important area of clinical care and research. First, CF may disease-specific problems, including cyclic pulmonary symptoms, vaginal yeast infections, urinary incontinence. Next, contraceptive methods are thought to be overall safe effective, however further research is needed confirm this understand the lower rates uptake among compared general population. Further, reduced...
Background: Hypoglycemia is the most common complication of type 1 diabetes (T1D) in children. prevents optimal glycemic control and can have deleterious effects on developing brain. Clinical Case: A 2-year-old female was diagnosed with T1D started an insulin regimen detemir lispro. At age 3, she transitioned to a Medtronic 530 G pump Enlite continuous glucose monitor. For 7 months, had stable requirement without significant issues. Thereafter, family reporting severe nighttime hypoglycemia...
To assess changes in diabetes autoantibodies (DAs) over time children and young adults with determine whether observed were associated demographic characteristics, clinical parameters complications. Participants had DAs measured at baseline (10.3 ± 7.1 months after diagnosis) 12, 24 ≥5 years the measurement. At ≥5-year follow-up, presence of complications was assessed. We examined associations between change number positive individual DA status participants' characteristics time. Out 4179...
Screening for household food insecurity (HFI) is recommended because of its impact on diabetes management. While HFI has been shown to be associated with poor glycemic control in adults type 2 (T2D) and youth young (YYA) 1, the association between YYA T2D not known. This cross-sectional study included (n=395) from 2015-2020 SEARCH Diabetes Youth Study (14-35 yrs; median age: 25.2 yrs). was defined as affirming ≥3 items US Household Food Security Survey Module. HbA1c values were available 271...