A5086079401- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Food Security and Health in Diverse Populations
- Alzheimer's disease research and treatments
- Child Nutrition and Feeding Issues
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Breastfeeding Practices and Influences
- Early Childhood Education and Development
- Cannabis and Cannabinoid Research
- Language Development and Disorders
- Child Development and Digital Technology
- Health, Environment, Cognitive Aging
- Heart Rate Variability and Autonomic Control
- Child Nutrition and Water Access
- Pancreatic function and diabetes
- Infant Development and Preterm Care
- Child and Adolescent Psychosocial and Emotional Development
University of Colorado Anschutz Medical Campus
2015-2025
University of Colorado Denver
2014-2024
Children's Hospital Colorado
2021-2024
The Medical Center of Aurora
2018-2024
Colorado School of Public Health
2014-2023
Native Health
2015
University of North Carolina at Chapel Hill
2014
University of Michigan
1985
Maternal obesity increases the risk for pediatric obesity; however, molecular mechanisms in human infants remain poorly understood. We hypothesized that mesenchymal stem cells (MSCs) from born to obese mothers would demonstrate greater potential adipogenesis and less myogenesis, driven by differences β-catenin, a regulator of MSC commitment. MSCs were cultured umbilical cords normal-weight (prepregnancy [pp] BMI 21.1 ± 0.3 kg/m(2); n = 15; NW-MSCs) (ppBMI 34.6 1.0 14; Ob-MSCs). Upon...
The impact of specific maternal fuels and metabolic measures during early late gestation on neonatal body composition is not well defined.To determine how circulating glucose, lipids, insulin resistance in the first second halves pregnancy influence composition.A prospective pre-birth cohort enrolling pregnant women, Healthy Start Study, was conducted, which fasting serum samples were collected twice to measure insulin, hemoglobin A1c, triglyceride, total cholesterol, high-density...
Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood metabolic disease compared infants of normal weight mothers, though the cellular mechanisms mediating these effects unclear.We tested hypothesis that human, umbilical cord-derived mesenchymal stem cells (MSCs) from obese (Ob-MSC) versus (NW-MSC) demonstrate altered fatty acid metabolism consistent adult obesity. In infant MSCs undergoing myogenesis in vitro, we measured...
To assess the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life.We leveraged a subsample 103 mother-child pairs from Healthy Start, an ethnically diverse Colorado-based cohort. Twelve cannabinoids/metabolites (including Δ9-tetrahydrocannabinol cannabidiol) were measured maternal urine collected at ~27 weeks' gestation. Fetal was dichotomized as exposed (any cannabinoid > limit detection [LOD]) not (all cannabinoids < LOD). Fat mass fat-free via air...
Background: Prenatal exposure to cannabis may influence childhood cognition and behavior, but the epidemiologic evidence is mixed. Even less known about potential impact of secondhand during early childhood. Objective: This study sought assess whether prenatal and/or postnatal was associated with behavior. Study design: sub-study included a convenience sample 81 mother–child pairs from Colorado-based cohort. Seven common cannabinoids (including delta 9-tetrahydrocannabinol (Δ9-THC)...
ABSTRACT Objective To examine the relationship between levels of household food insecurity and disordered eating behaviors (DEB) among youth young adults with youth‐onset type 1 (T1D) 2 diabetes (T2D). Method We used cross‐sectional data from multicenter SEARCH for Diabetes in Youth Study (2015–2020). The Household Food Security Survey Module Eating Problem Survey‐Revised (DEPS‐R) were utilized to measure continuous scores DEB. In each stratum type, we evaluated association DEB through...
Maternal obesity is a global health problem that increases offspring risk. The metabolic pathways underlying early developmental programming in human infants at risk for remain poorly understood, largely due to barriers fetal/infant tissue sampling. Utilizing umbilical cord–derived mesenchymal stem cells (uMSC) from of normal weight and obese mothers, we tested whether energy metabolism gene expression differ differentiating uMSC myocytes adipocytes, relation maternal exposures and/or...
Summary Background Recent work has implicated disinhibited eating behaviours (DEB) as a potential pathway toward obesity development in children. However, the underlying neurobiology of young, healthy weight children, prior to development, remains unknown. Objectives This study tested relationship between DEB and intrinsic neuronal activity connectivity young children without obesity. Methods Brain networks overeating including reward, salience executive control networks, default mode...
Few studies have comprehensively examined how health and disease risk influence Alzheimer's (AD) biomarkers. The present study the association of 14 protein-based indicators with plasma neuroimaging biomarkers AD neurodegeneration.
A large body of research has established a relation between maternal education and children's neurocognitive functions, such as executive function language. However, most studies have focused on early childhood relatively few examined associations with changes in over time. Consequently, it remains unclear if is longitudinally related to functions children, adolescents, young adults. In addition, the across development more broadly defined outcomes remain untested. The current study...
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from offspring born to normal-weight and obese mothers, we tested the hypothesis that changes in infant body composition over first 5 months of life correspond with differences cellular metabolism transcriptomic profiles at birth. Higher long-chain acylcarnitine concentrations, lipid transport...
To examine the association between dysglycaemia and multiple modifiable factors measured during pregnancy.The Healthy Start Study collected self-reported data on in early mid-pregnancy (median 17 27 weeks gestation, respectively) from 832 women. Women received one point for each factor which they had optimum scores: diet quality (Healthy Eating Index score ≥64), physical activity level (estimated energy expenditure ≥170 metabolic equivalent task-h/week), mental health status (Perceived...
Key Points Participants with CKD had detectable cognitive deficits in fluid cognition, dexterity, and total cognition. Sex differences cognition exist people CKD. Background is largely an age-related clinical disorder accelerated cardiovascular aging. Cognitive impairment a well-documented occurrence midlife older adults affects multiple domains. We examined function potential sex Methods included 105 individuals (49.5% women) stage 3b–4 (eGFR, 15–44 ml/min) from the Bicarbonate...
OBJECTIVE To examine short-term mortality and cause of death among youth young adults (YYAs) with youth-onset diabetes. RESEARCH DESIGN AND METHODS We included 19,717 YYAs newly diagnosed diabetes before 20 years age from 1 January 2002 to 31 December 2015 enrolled in the SEARCH for Diabetes Youth Study. Of these, 14,721 had type 1; 4,141 2; 551 secondary 304 other/unknown type. Cases were linked National Death Index through 2017. calculated standardized ratios (SMRs) 95% CIs based on age,...