A5079840473- Diabetes Management and Research
- Acute Myeloid Leukemia Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Brain Metastases and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Meningioma and schwannoma management
- Cardiovascular Health and Disease Prevention
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Cancer survivorship and care
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Cardiovascular Function and Risk Factors
- Agriculture and Farm Safety
- Frailty in Older Adults
- Hematopoietic Stem Cell Transplantation
- Nutrition and Health in Aging
- Obesity and Health Practices
- Heart Rate Variability and Autonomic Control
Wake Forest University
2015-2024
Atrium Health Wake Forest Baptist
2013-2023
Wake Forest Baptist Comprehensive Cancer Center
2018-2023
Comprehensive Blood & Cancer Center
2021
U-M Rogel Cancer Center
2021
Wake County Public School System
2020
Hyattsville Community Development Corporation
2020
W. G. (Bill) Hefner VA Medical Center
2016
Winston-Salem State University
2015
University Surgical Associates
2014
Diagnoses of type 1 and 2 diabetes in youths present a substantial clinical public health burden. The prevalence these diseases increased the 2001-2009 period, but data on recent incidence trends are lacking.
<h3>Importance</h3> Changes in the prevalence of youth-onset diabetes have previously been observed. <h3>Objective</h3> To estimate changes type 1 and 2 youths US from 2001 to 2017. <h3>Design, Setting, Participants</h3> In this cross-sectional observational study, individuals younger than 20 years with physician-diagnosed were enumerated 6 areas (4 geographic areas, health plan, select American Indian reservations) for 2001, 2009, <h3>Exposures</h3> Calendar year. <h3>Main Outcomes...
Diabetes is one of the most common chronic diseases among persons aged <20 years (1). Onset diabetes in childhood and adolescence associated with numerous complications, including diabetic kidney disease, retinopathy, peripheral neuropathy, has a substantial impact on public health resources (2,3). From 2002 to 2012, type 1 2 incidence increased 1.4% 7.1%, respectively, U.S. youths (4). To assess recent trends (defined for this report as years), researchers analyzed 2002-2015 data from...
We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) 2 (T2D) enrolled SEARCH Diabetes Youth (SEARCH) study.
OBJECTIVE To project the prevalence and number of youths with diabetes trends in racial ethnic disparities U.S. through 2060. RESEARCH DESIGN AND METHODS Based on a mathematical model data from SEARCH for Diabetes Youth study calendar years 2002–2017, we projected future type 1 2 among youth aged &lt;20 while considering different scenarios incidence. RESULTS The will increase 213,000 (95% CI 209,000; 218,000) (type 185,000, 28,000) 2017 to 239,000 282,000) 191,000, 48,000) 2060 if...
To determine whether [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) can delineate patients with esophageal cancer who may not benefit from esophagectomy after chemoradiotherapy.We reviewed records of 163 histologically confirmed stage I to IVA receiving chemoradiotherapy or without resection curative intent. All received surgical evaluation. Initial and postchemoradiotherapy FDG-PET scans prognostic/treatment variables were analyzed. complete response (PET-CR) was defined...
Objectives To test the feasibility and utility of a bedside geriatric assessment ( GA ) to detect impairment in multiple domains older adults initiating chemotherapy for acute myelogenous leukemia AML ). Design Prospective observational cohort study. Setting Single academic institution. Participants Individuals aged 60 with newly diagnosed planned chemotherapy. Measurements Bedside was performed during inpatient exmination . measures included modified Mini‐Mental State Examination; Center...
This analysis described Latino migrant farmworkers' work safety climate and its association with musculoskeletal discomfort, working while injured or ill, depressive symptoms.
Abstract Purpose: The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial metabolism. This study determined the effects of on function and defined MTD, pharmacokinetics, safety in patients with relapsed or refractory hematologic malignancies. Experimental Design: Human leukemia cell lines were exposed to was assayed. A phase I trial conducted which given as 2-hour infusion days 1 4 for 3 weeks every 28 days. Results: inhibited respiration human cells consistent...
We review our single institution experience to determine predictive factors for early and delayed distant brain failure (DBF) after radiosurgery without whole radiotherapy (WBRT) metastases.Between January 2000 December 2010, a total of 464 patients were treated with Gamma Knife stereotactic (SRS) WBRT primary management newly diagnosed metastases. Histology, systemic disease, RPA class, number metastases evaluated as possible predictors DBF rate. rates determined by serial MRI. Kaplan-Meier...
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism chemotherapy response determined MTD, efficacy, safety CPI-613 combined high-dose cytarabine mitoxantrone relapsed or refractory acute leukemia.Experimental Design: The to was assessed cell lines animal models. A phase I plus conducted AML.Results: Exposure induced oxygen...
To describe temporal trends and correlates of glycemic control in youth young adults (YYA) with youth-onset diabetes.
The purpose of this study was to determine the effects a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women.Four hundred twenty-four (age = 70-89 yr), nondisabled, community-dwelling women at risk for disability were enrolled multicenter, single-blind, randomized controlled trial. Participants participate either moderate-intensity PA or successful aging health education intervention. Biomarkers inflammation (interleukin (IL)-6sR, IL-1sRII,...
Immigrant Latino farmworkers confront multiple challenges that threaten their mental health. Previous farmworker health research has relied primarily on cross-sectional study designs, leaving little opportunity to describe how changes or identify factors may contribute these changes. This used prospective data obtained at monthly intervals across one 4-month agricultural season from a large sample of in North Carolina (N = 288) document variation depressive symptoms the and delineate...
Abstract BACKGROUND The Src tyrosine kinase substrate and adaptor protein Tks5 had previously been implicated in the invasive phenotype of normal transformed cell types via regulation cytoskeletal structures called podosomes/invadopodia. role Src‐Tks5 signaling prostate cancer, however, not evaluated. METHODS We measured relative expression (n = 20) cancerous 184, from 92 patients) tissue specimens by immunohistochemistry using a commercially available tumor microarray. also manipulated...
In this study we attempted to discern the factors predictive of neurologic death in patients with brain metastasis treated upfront stereotactic radiosurgery (SRS) without whole radiation therapy (WBRT) while accounting for competing risk nonneurologic death. We performed a retrospective single-institution analysis SRS WBRT. Competing risks was estimate subdistribution hazard ratios (HRs) and predictor variables interest. Of 738 alone, occurred 226 (30.6%), 309 (41.9%). Multivariate...
The aim of the study was to evaluate short and long-term effects acupuncture on vasomotor symptoms (VMS) quality life-related measures.A total 209 perimenopausal postmenopausal women aged 45 60 years, experiencing four or more VMS per day, were recruited from community randomized receive up 20 treatments within first 6 months (acupuncture group) second (waitlist control 12-month period. primary outcome mean daily frequency VMS. Secondary outcomes interference with life, sleep quality,...
Background The incidence of type 1 diabetes mellitus (T1DM) in children is increasing, resulting higher burden cardiovascular diseases due to mellitus–related vascular dysfunction. Methods and Results We examined risk factors ( CVRF s) arterial parameters 1809 youth with T1DM. Demographics, anthropometrics, blood pressure, laboratory data were collected at T1DM onset 5 years later. Pulse wave velocity augmentation index tonometry. ANOVA or chi‐square tests used test for differences measures...
Abstract Devimistat is a TCA cycle inhibitor. A previously completed phase I study of devimistat in combination with cytarabine and mitoxantrone patients relapsed or refractory AML showed promising response rates. Here we report the results single arm II (NCT02484391). The primary outcome feasibility maintenance following induction consolidation high dose was not met, as only administered 2 21 responders. secondary outcomes (CR + CRi) median survival were 44% (21/48) 5.9 months respectively....
Abstract Background Several studies have documented poor housing conditions for farmworkers but none has focused on migrant farmworker housing, which is often provided as a condition of employment. Farmworker quality regulated, little documentation exists compliance with regulations. Methods A 2007 survey 43 randomly selected camps and 2008 27 from the sample via interviewer administered questionnaire checklist. Results Substandard are common in housing. All had at least one exterior...
// Adam G. Johnson 1 , Jimmy Ruiz 2, 3 Ryan Hughes Brandi R. Page Scott Isom 4 John T. Lucas Emory McTyre Kristin W. Houseknecht Diandra N. Ayala-Peacock Daniel J. Bourland William H. Hinson Adrian Laxton 5 Stephen B. Tatter Waldemar Debinski 6 Kounosuke Watabe 7 Michael D. Chan Department of Radiation Oncology, Wake Forest School Medicine, Winston-Salem, NC, USA 2 Section on Hematology and W.G. (Bill) Hefner Veteran Administration Medical Center, Cancer Salisbury, Biostatistical Sciences,...