A5015883421- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- Frailty in Older Adults
- Cardiac Imaging and Diagnostics
- Innovations in Medical Education
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer survivorship and care
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Cancer-related cognitive impairment studies
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Childhood Cancer Survivors' Quality of Life
- Patient-Provider Communication in Healthcare
- Advanced MRI Techniques and Applications
- Electronic Health Records Systems
- Clinical Laboratory Practices and Quality Control
Prostate Cancer UK
2025
Atrium Health Wake Forest Baptist
2015-2024
Wake Forest Baptist Comprehensive Cancer Center
2024
Wake Forest University
2011-2022
Swedish Medical Center
2017
U-M Rogel Cancer Center
2011
Comprehensive Blood & Cancer Center
2011
Memorial Sloan Kettering Cancer Center
2005
University of North Carolina at Chapel Hill
1977
PURPOSE Cancer survivors exposed to anthracyclines experience an increased risk of cardiovascular (CV) events. We hypothesized that anthracycline use may increase aortic stiffness, a known predictor CV PATIENTS AND METHODS performed prospective, case-control study involving 53 patients: 40 individuals who received for the treatment breast cancer, lymphoma, or leukemia (cases), and 13 age- sex-matched controls. Each participant underwent phase-contrast magnetic resonance measures pulse wave...
Objectives To test the feasibility and utility of a bedside geriatric assessment ( GA ) to detect impairment in multiple domains older adults initiating chemotherapy for acute myelogenous leukemia AML ). Design Prospective observational cohort study. Setting Single academic institution. Participants Individuals aged 60 with newly diagnosed planned chemotherapy. Measurements Bedside was performed during inpatient exmination . measures included modified Mini‐Mental State Examination; Center...
Background: Myocardial atrophy and left ventricular (LV) mass reductions are associated with fatigue exercise intolerance. The relationships between the receipt of anthracycline-based chemotherapy (Anth-bC) changes in LV heart failure (HF) symptomatology unknown, as is their relationship to ejection fraction (LVEF), a widely used measurement performed surveillance strategies designed avert symptomatic HF cancer treatment. Methods Results: We blinded, serial assessments body weight, LVEF...
Abstract Purpose: The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial metabolism. This study determined the effects of on function and defined MTD, pharmacokinetics, safety in patients with relapsed or refractory hematologic malignancies. Experimental Design: Human leukemia cell lines were exposed to was assayed. A phase I trial conducted which given as 2-hour infusion days 1 4 for 3 weeks every 28 days. Results: inhibited respiration human cells consistent...
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism chemotherapy response determined MTD, efficacy, safety CPI-613 combined high-dose cytarabine mitoxantrone relapsed or refractory acute leukemia.Experimental Design: The to was assessed cell lines animal models. A phase I plus conducted AML.Results: Exposure induced oxygen...
Background— In a murine anthracycline-related cardiotoxicity model, increases in cardiovascular magnetic resonance myocardial contrast-enhanced T1-weighted signal intensity are associated with myocellular injury and decreases left ventricular ejection fraction. We sought to determine whether T1- T2-weighted measures of associate fraction human subjects receiving potentially cardiotoxic chemotherapy. Methods Results— 65 individuals breast cancer (n=51) or hematologic malignancy (n=14), we...
To measure short-term changes in physical and cognitive function emotional well-being of older adults receiving intensive chemotherapy for acute myeloid leukemia (AML).Prospective observational study.Single academic institution.Individuals aged 60 with newly diagnosed AML who received induction (N = 49, mean age 70 ± 6.2, 56% male).Geriatric assessment (GA) was performed during inpatient examination within 8 weeks after hospital discharge chemotherapy. Measures were the Pepper Assessment...
Abstract Devimistat is a TCA cycle inhibitor. A previously completed phase I study of devimistat in combination with cytarabine and mitoxantrone patients relapsed or refractory AML showed promising response rates. Here we report the results single arm II (NCT02484391). The primary outcome feasibility maintenance following induction consolidation high dose was not met, as only administered 2 21 responders. secondary outcomes (CR + CRi) median survival were 44% (21/48) 5.9 months respectively....
OPEN ACCESSOctober 28, 2020The Electronic Health Record Objective Structured Clinical Examination Station: Assessing Student Competency in Patient Notes and Interaction E. Shen, PhD, Joseph Anthony Cristiano, MD, Leslie Renee Ellis, MSHPEd PhD https://orcid.org/0000-0001-6751-5445 Assistant Professor, Department of Internal Medicine, Section General Wake Forest Baptist , MD https://orcid.org/0000-0003-1388-5867 https://orcid.org/0000-0003-0459-7951 Associate on Hematology Oncology, E-mail...
Graduate medical education training in hematology North America is accredited by the Accreditation Council for Medical Education (ACGME). Trainees routinely review peripheral blood smears (PBS) providing clinical care. Competency PBS at graduation required ACGME. However, there are no consensus guidelines on best practices surrounding review, education, or competency. We describe generation of proposed theory and recommendations developed through a multi-institutional focus group, using...
7015 Background: CPI-613 is a novel agent that targets mitochondrial metabolism. It inhibits respiration in AML cells and single phase I study was active for several patients with myeloid malignancies.This trial designed to determine the maximum tolerated dose (MTD) efficacy of combination HDAC mitoxantrone relapsed or refractory AML. Methods: given daily on days 1 through 5 starting at 500 mg/m2. Beginning day 3, (3,000 mg/m2 1,500 age ≥ 60) every 12 hours doses 6 3 doses. If residual...