A5057545412- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Electronic Health Records Systems
- Chromatin Remodeling and Cancer
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Cancer, Hypoxia, and Metabolism
- Medical Coding and Health Information
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Biomedical Text Mining and Ontologies
- Tuberculosis Research and Epidemiology
- Neutropenia and Cancer Infections
- Cancer, Stress, Anesthesia, and Immune Response
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
Tennessee Oncology
2021-2022
Atrium Health Wake Forest Baptist
2013-2020
Wake Forest University
2017-2020
Wake Forest Baptist Comprehensive Cancer Center
2019-2020
University College London
2018
University College Hospital
2018
Swedish Medical Center
2017
Cardiff University
2012
Tapestry Health
2006
Westchester Medical Center
2006
Up to 40% of lung cancer patients develop brain metastasis, and the median survival these remains less than 6 months. Smoking is associated with cancer. However, how smoking impacts development metastasis elusive. We examined 281 distant found that smokers exhibited a significantly high incidence metastasis. nicotine enhanced while depletion microglia suppressed this effect in vivo. Nicotine skewed polarity M2 phenotype, thereby increasing secretion IGF-1 CCL20, which promoted tumor...
Abstract Background The effect of immunotherapy on brain metastasis patients remains incompletely understood. Our goal was to evaluate its survival, neurologic death, and patterns failure after stereotactic radiosurgery (SRS) without prior whole-brain radiation therapy (WBRT) in with lung melanoma primaries metastatic the brain. Methods We performed a retrospective analysis 271 consecutive or treated upfront SRS for metastases between 2013 2018. Of these patients, 101 (37%) received 170...
KRAS is a key oncogenic driver in lung adenocarcinoma (LUAD). Chromatin-remodeling gene SMARCA4 comutated with LUAD; however, the impact of mutations on clinical outcome has not been adequately established. This study sought to shed light significance LUAD. The association survival outcomes was interrogated four independent cohorts totaling 564 patients: KRAS-mutant patients LUAD who received nonimmunotherapy treatment from (a) Cancer Genome Atlas (TCGA) and (b) MSK-IMPACT Clinical...
The combination of standard‑dose chemotherapy and immunotherapy has been shown to be beneficial for patients with non‑small cell lung cancer (NSCLC) good performance status (PS). However, treatment options poor PS are limited. In the present study, feasibility immunological effects low‑dose carboplatin paclitaxel combined pembrolizumab were examined in metastatic NSCLC a PS. Patients advanced 2 randomized single‑agent at 200 mg every 3 weeks or weekly area under curve 1 25 mg/m2. Blood...
Background: examine baseline dyspnoea and subsequent 10-year mortality adjusting for age gender determine whether is related to early or late both. Examine the relationship between confounding effects of underlying diseases. Methods: we sent modified Medical Research Council (MRC) questionnaire identify breathlessness in 1,404 randomly selected subjects from general practitioner lists 5,002 aged 70 years over living community. A further random sample 500 underwent clinical assessment...
Structured diagnosis (DX) are crucial for secondary use of electronic health record (EHR) data. However, they often suboptimally recorded. Our previous work showed initial evidence variable DX recording patterns in oncology charts even after biopsy records available.We verified this finding's internal and external validity. We hypothesized that pattern would be preserved a larger cohort patients the same disease. also effect vary across subspecialties.We extracted data from EHRs treated...
Accurate recording of diagnosis (DX) data in electronic health records (EHRs) is important for clinical practice and learning care. Previous studies show statistically stable patterns entry EHRs that contribute to inaccurate DX, likely because a lack support. We conducted qualitative research characterize the preferences oncological care providers on cancer DX during practice.We semistructured interviews focus groups uncover common themes barriers accurate recording. Then, we developed...
Small cell carcinoma (SCC) is a rare variant of head and neck cancer characterized by high-grade neuroendocrine with similar features to small lung (SCLC). Human papillomavirus (HPV) an increasingly recognized cause but usually associated squamous the oropharynx. In this report, we present clinical presentation, diagnosis, management patient HPV-related SCC oropharynx that responded favorably chemotherapy cisplatin plus etoposide concomitant radiation therapy, regimen typically used in...
We sought to identify candidate biomarkers for early brain metastasis (BM) recurrence in patients who underwent craniotomy followed by adjuvant stereotactic radiosurgery. RNA sequencing was performed on eight resected tissue samples and revealed B-cell related genes be highly expressed did not experience a distant failure had prolonged overall survival. To translate the findings from data, we immunohistochemistry stain B T cell markers formalin-fixed parffin-embedded blocks 13 patients....
Background: Concomitant chemo-radiation therapy (CRT) with cisplatin is the mainstay of treatment for patients locally advanced head and neck cancer. Nephrotoxicity a well-documented adverse effect cisplatin, which exacerbated by dehydration, common complication in this group patients. This study prospectively assessed utility urine specific gravity (USG) as guide fluid replacement, its preventive induced nephrotoxicity. Methods: Patients cancer who received CRT weekly at our institution...