A5101696170- Glycosylation and Glycoproteins Research
- Traditional Chinese Medicine Studies
- Brain Metastases and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Stress, Anesthesia, and Immune Response
- Food Quality and Safety Studies
- Cancer Cells and Metastasis
- Tuberculosis Research and Epidemiology
- Safety and Risk Management
- Virus-based gene therapy research
- Microbial Metabolic Engineering and Bioproduction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- Carbohydrate Chemistry and Synthesis
- HIV, Drug Use, Sexual Risk
- Cerebrovascular and Carotid Artery Diseases
- Extracellular vesicles in disease
- HIV/AIDS Research and Interventions
- Lipid metabolism and disorders
- Higher Education and Teaching Methods
- Cardiac Ischemia and Reperfusion
- Cancer-related gene regulation
- Facial Rejuvenation and Surgery Techniques
- Cancer Treatment and Pharmacology
Nanjing Drum Tower Hospital
2010-2025
Chongqing Medical University
2012-2025
Children's Hospital of Chongqing Medical University
2012-2025
Port Moresby General Hospital
2025
Kunming Medical University
2009-2024
Sun Yat-sen University
2013-2024
Nankai University
2009-2024
Utah State University
2019-2024
Fudan University Shanghai Cancer Center
2021-2024
Shanghai Medical College of Fudan University
2021-2024
Abstract Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients with estrogen-positive tumors experience a significantly higher incidence bone (>87%) compared to estrogen-negative (<56%). To understand the mechanism this bone-tropism ER + tumor, and identify liquid biopsy biomarkers for high risk metastasis, secreted extracellular vesicles cytokines from bone-tropic cancer cells are examined in study. Both exosomal miR-19a Integrin-Binding...
Research Article5 March 2013Open Access Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain Fei Xing Department Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School Medicine, Springfield, IL, USA Cancer Institute, Mississippi Center, Jackson, MS, Search for more papers this author Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Internal Iwate...
Abstract Brain metastasis is one of the chief causes mortality in breast cancer patients, but mechanisms that drive this process remain poorly understood. Here, we report brain metastatic cells expressing high levels c-Met promote via inflammatory cytokine upregulation and vascular reprogramming. Activated signaling promoted adhesion tumor to endothelial enhanced neovascularization by inducing secretion IL8 CXCL1. Additionally, stimulation IL1β activation induced tumor-associated astrocytes...
Prostate cancer is known to frequently recur in bone; however, how dormant cells switch its phenotype leading recurrent tumor remains poorly understood. We have isolated two syngeneic cell lines (indolent and aggressive) through vivo selection by implanting PC3mm stem-like into tibial bones. found that indolent retained the phenotype, whereas aggressive grew rapidly bone vivo, growth rates of both culture were similar, suggesting a role microenvironment regulation dormancy recurrence....
Up to 40% of lung cancer patients develop brain metastasis, and the median survival these remains less than 6 months. Smoking is associated with cancer. However, how smoking impacts development metastasis elusive. We examined 281 distant found that smokers exhibited a significantly high incidence metastasis. nicotine enhanced while depletion microglia suppressed this effect in vivo. Nicotine skewed polarity M2 phenotype, thereby increasing secretion IGF-1 CCL20, which promoted tumor...
Brain metastases are a major cause of death in patients with metastatic breast cancer. While surgical resection and radiation therapy effective treatment modalities, the majority will succumb from disease progression. We have developed novel for brain that delivers athermal radiofrequency electromagnetic fields amplitude-modulated at cancer specific frequencies (BCF).27.12 MHz BCF were administered to patient metastasis by placing spoon-shaped antenna on anterior part tongue three one-hour...
To evaluate the feasibility of using a multigene signature to tailor individualised adjuvant therapy for patients with operable triple negative breast cancer.
Concussive injury (or mild traumatic brain injury; mTBI) can exhibit features of focal or diffuse patterns. We compared and contrasted the cellular molecular responses after controlled cortical impact (mCCI; a injury) fluid percussion (FPI; in rats. The rationale for this comparative analysis was to investigate brain's response versus identify common changes triggered by these modalities determine functional pathways altered that may provide novel targets therapeutic intervention....
We aimed to track the global trend of cosmetic treatment outcomes for facial rejuvenation and differences in modalities used East Asian Western populations.
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed. Two hundred sixty eight patients IPF were grouped different severity according to area, serum Club cell secretory protein 16(CC16) compared between these groups. All randomly divided into training testing sets. COX regression LASSO algorithm used screen featured characteristics. Then models constructed, ROC curve, calibration...
To evaluate the accuracy and comprehensiveness of eight free, publicly available large language model (LLM) chatbots in addressing common questions related to chronic neonatal lung disease (CNLD) home oxygen therapy (HOT). Twenty CNLD HOT-related were curated across nine domains. Responses from ChatGPT-3.5, Google Bard, Bing Chat, Claude 3.5 Sonnet, ERNIE Bot 3.5, GLM-4 generated evaluated by three experienced neonatologists using Likert scales for comprehensiveness. Updated LLM models...
To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models.This is a retrospective observational study of serum samples from 45 participants aSAH analyzed at multiple predetermined time points: <24 hours, 24 to 48 3 5 days, and 6 8 days aSAH. Concentrations cytokines were measured 41-plex human immunoassay kit, the Pearson correlation coefficients between all possible cytokine pairs computed. Systematic models constructed on basis correlations...
The quality of strong-flavor Baijiu, a prominent Chinese liquor, is intricately tied to the choice sorghum variety used in fermentation. However, significant gap remains our understanding how glutinous and non-glutinous varieties comprehensively impact Baijiu flavor formation through fermentation metabolites. This study employed untargeted metabolomics combined with feature-based molecular networking (FBMN) explore unique metabolic characteristics these two during FBMN analysis revealed 267...
Hypoplastic coronary artery disease is a rare congenital abnormality that associated with sudden cardiac death. However, molecular mechanisms responsible for this are not clear. The aim of the present study was to assess role nitric oxide synthase-3 (NOS3) in pathogenesis hypoplastic arteries. Wild-type (WT), NOS3−/−, and novel cardiac-specific NOS3 overexpression mouse model were employed. Deficiency resulted hypoplasia foetal mice spontaneous myocardial infarction postnatal hearts....
Background The present study was aimed to evaluate the role and safety of surgical lung biopsies (SLB) in patients with interstitial disease (ILD) China. Methods A retrospective analysis 418 ILD undergoing SLB from Chinese literature data our hospital during past ten years performed. Results total cases underwent SLB, including open biopsy (OLB) 229 video-assisted thoracoscopic (VATLB) 189 cases. yielded a specific diagnosis for 88.0% cases, unclassifiable idiopathic pneumonia seen 9.1%...
Tissue factor (TF) expression on islets has been shown to trigger instant blood-mediated inflammatory reaction (IBMIR), leading rapid islet loss in portal vein transplantation. This study investigated whether antisense RNA-mediated TF gene knockdown could suppress IBMIR as a strategy overcome IBMIR. Neonatal porcine cell clusters (NICCs) were transfected with or without TF-specific RNA nonspecific by lipid-based method. Expression of both and protein NICCs was analyzed after transfection...
Purpose. To examine the effect of parental support on sedentary behaviors among Hispanic children. Design and Setting. A longitudinal quasi-experimental design with five waves data collection was used to children's in a school-based intervention program west Texas. Subjects. low-income parents their children 5 9 years (N = 416 child-parent dyads) over 22-month period (1217 observations). Intervention. Transformation Para Salud multicomponent aimed at prevention control childhood overweight...
The aim of this study was to investigate focal iron deposition level in the brain patients with ischemic cerebrovascular disease and its correlation cerebral small vessel imaging markers.Seventy-four first-ever transient attack (median age: 69 years; 30 males 44 females) 77 positive stroke history 72 43 34 were studied retrospectively. On phase image susceptibility-weighted regions interest manually drawn at bilateral head caudate nucleus, lenticular nucleus (LN), thalamus (TH), frontal...
Abstract Background C‐Jun and EGFR have not been explored as targets via the mechanism of RNA silencing . Hence, this study designed an efficient C‐Jun‐h‐825 small interfering (siRNA) investigated its effect on matrix metalloproteinase (MMP) collagen expression in human keratinocytes exposed to UV radiation. Methods Five siRNAs were screened for their ability downregulate fibroblasts. These constructs used changes skin cancer‐related protein expression. HaCaT cells grouped into...
Background Salivary nitrate is positively correlated with plasma and its level 9 times the after loading. Nitrate in saliva known to be reduced nitrite by oral bacteria. levels are 3–5 those serum physiological conditions respectively our previous study. The biological functions of high salivary still not well understood. aim this vitro study was investigate antimicrobial effects on main pathogens under acidic conditions. Methods Six common including Streptococcus mutans NCTC 10449,...
A Gram-staining-negative bacterium, designated strain BLN2(T), was isolated from within the roots of reeds (Phragmites australis) in Beijing Cuihu Wetland (China) and characterized using a polyphasic taxonomic approach. The cells were yellow-pigmented, rod-shaped, strictly aerobic devoid flagella, but showed gliding motility. Strain BLN2(T) produced yellow, translucent, circular convex colonies, with optimal growth at 30 °C pH 7.0. major respiratory quinone menaquinone 6 (MK-6) predominant...