A5029311650- Frailty in Older Adults
- Nutrition and Health in Aging
- Cancer survivorship and care
- Acute Myeloid Leukemia Research
- Palliative Care and End-of-Life Issues
- Neutropenia and Cancer Infections
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced cardiotoxicity and mitigation
- Economic and Financial Impacts of Cancer
- Cardiovascular Health and Risk Factors
- Occupational and environmental lung diseases
- Histone Deacetylase Inhibitors Research
- Breast Cancer Treatment Studies
- Chronic Disease Management Strategies
- Global Cancer Incidence and Screening
- Bone and Joint Diseases
- Cardiac Health and Mental Health
- Multiple and Secondary Primary Cancers
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical Practices and Patient Outcomes
- Hematopoietic Stem Cell Transplantation
Wake Forest University
2016-2025
Atrium Health Wake Forest Baptist
2016-2025
Wake Forest Baptist Comprehensive Cancer Center
2015-2024
ThedaCare
2024
Regional Cancer Center
2016-2024
Apple (Israel)
2024
University Health System
2023
Virginia Commonwealth University
2022
Comprehensive Blood & Cancer Center
2011-2021
U-M Rogel Cancer Center
2011-2021
Older adults are vulnerable to chemotherapy toxicity; however, there limited data identify those at risk. The goals of this study risk factors for toxicity in older and develop a stratification schema toxicity.Patients age ≥ 65 years with cancer from seven institutions completed prechemotherapy assessment that captured sociodemographics, tumor/treatment variables, laboratory test results, geriatric variables (function, comorbidity, cognition, psychological state, social activity/support,...
Purpose To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic review medical literature. Results A total 68 studies met eligibility criteria form evidentiary basis for recommendations. Recommendations In ≥ 65 years receiving chemotherapy, geriatric (GA) should be used identify that are not routinely...
Purpose Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those risk. A predictive model toxicity was developed (N = 500) that consisted of geriatric questions other clinical variables. This study aims to externally validate this in an independent cohort 250). Patients Methods age ≥ 65 years with a solid tumor, fluent English, who were scheduled receive new regimen recruited from eight institutions. Risk calculated (low,...
The coronavirus disease 2019 (COVID-19) pandemic has disrupted all aspects of clinical care, including cancer trials. In March 2020, ASCO launched a survey programs represented on its Cancer Research Committee and Community Forum Steering Group taskforces to learn about the types changes challenges that trial were experiencing early in pandemic. There 32 respondents; 14 academic programs, 18 community-based programs. Respondents indicated COVID-19 is leading halt or prioritize screening...
BACKGROUND Frailty has been suggested as a construct for oncologists to consider in treating older cancer patients. Therefore, the authors assessed potential of creating deficit‐accumulation frailty index (DAFI) from largely self‐administered comprehensive geriatric assessment (CGA). METHODS Five hundred patients aged ≥65 years underwent CGA before receiving chemotherapy. A DAFI was constructed, resulting 51‐item scale, and cutoff values were examined robust/nonfrail (cutoff value, 0.0 <...
For patients with cancer who are older than 65 years, the 2018 ASCO Guideline recommends geriatric assessment (GA) be performed. However, there limited data on providers' practices using GA. Therefore, ASCO's Geriatric Oncology Task Force conducted a survey of providers to assess practice patterns and barriers
Limited tools exist to predict the risk of chemotherapy toxicity in older adults with early-stage breast cancer.Patients age ≥ 65 years stage I-III cancer from 16 institutions treated neoadjuvant or adjuvant were prospectively evaluated for geriatric and clinical features predictive grade 3-5 toxicity. Logistic regression best-subsets selection was used identify incorporate independent predictors into a model weighted variable scoring. Model performance using area under ROC curve (AUC)...
Objectives To test the feasibility and utility of a bedside geriatric assessment ( GA ) to detect impairment in multiple domains older adults initiating chemotherapy for acute myelogenous leukemia AML ). Design Prospective observational cohort study. Setting Single academic institution. Participants Individuals aged 60 with newly diagnosed planned chemotherapy. Measurements Bedside was performed during inpatient exmination . measures included modified Mini‐Mental State Examination; Center...
To evaluate the prevalence of polypharmacy and potentially inappropriate medication (PIM) use association between these chemotherapy-related adverse events in older adults with cancer undergoing chemotherapy.Secondary analysis prospectively collected data.Outpatient oncology clinics seven academic medical centers.Adults aged 65 chemotherapy.Measures included number daily medications (polypharmacy); PIM based on three indices (Beers, Zhan, Drugs to Avoid Elderly criteria), six "high risk"...
Objective In older men with prostate cancer, aging is associated reduced anxiety and increased depression. The purpose of this study was to examine the association among age, anxiety, depression in a cohort adults receiving chemotherapy. Methods This secondary analysis prospective longitudinal investigating chemotherapy toxicity cancer. Baseline data (pre-chemotherapy) included: sociodemographics, tumor treatment factors, functional status, comorbidities, psychological state (measured by...
Background: Myocardial atrophy and left ventricular (LV) mass reductions are associated with fatigue exercise intolerance. The relationships between the receipt of anthracycline-based chemotherapy (Anth-bC) changes in LV heart failure (HF) symptomatology unknown, as is their relationship to ejection fraction (LVEF), a widely used measurement performed surveillance strategies designed avert symptomatic HF cancer treatment. Methods Results: We blinded, serial assessments body weight, LVEF...
Objectives To analyze self‐reported changes in physical function older women with breast cancer receiving adjuvant chemotherapy. Design Secondary analysis of the Cancer and Leukemia Group B (CALGB) 49907 prospective randomized clinical trial. Setting CALGB institutions United States. Participants Women aged 65 Stage I to III enrolled who had data from before after receipt chemotherapy (N=256; mean age 71.5, range 65–85). Measurements were administered subscale European Organization for...
<h3>Importance</h3> Progressive loss of muscle mass and strength, known as sarcopenia, is a well-known phenomenon aging; however, little about the trajectory sarcopenia measures before after cancer diagnosis its contribution to subsequent disability. <h3>Objective</h3> To examine rate decline (ie, appendicular lean [ALM], physical performance) in older adults with both compared population without cancer, secondarily assess association overall survival major disability patients cancer....
The use of a standardized geriatric assessment (GA) to inform treatment decisions in older adults with cancer improves quality life, reduces treatment-related toxicity, and is guideline-recommended. This study aimed assess community oncologists' knowledge utilization GAs.Between September 2019 February 2020, practicing US-based oncologists were invited attend live meetings complete web-based surveys designed collect information on decision making various practice-based challenges oncology...
In 2023, ASCO updated its guideline on assessment and management of vulnerabilities in older patients undergoing chemotherapy.The update revisited recommendations from the previous ( 2018), 1 light significant advances field since then introduced an innovative geriatric (GA) tool.][4] This companion Questions Answers article addresses some concerns that clinicians experience as they implement recommendations.
OBJECTIVES: To evaluate objective physical performance measures as predictors of survival and subsequent disability in older patients with cancer. DESIGN: Longitudinal cohort study. SETTING: Health, Aging Body Composition (Health ABC) Study. PARTICIPANTS: Four hundred twenty‐nine individuals diagnosed cancer during the first 6 years follow‐up Health ABC MEASUREMENTS: The associations between precancer (20‐m usual gait speed, 400‐m long‐distance corridor walk (LDCW), grip strength) overall a...
To measure short-term changes in physical and cognitive function emotional well-being of older adults receiving intensive chemotherapy for acute myeloid leukemia (AML).Prospective observational study.Single academic institution.Individuals aged 60 with newly diagnosed AML who received induction (N = 49, mean age 70 ± 6.2, 56% male).Geriatric assessment (GA) was performed during inpatient examination within 8 weeks after hospital discharge chemotherapy. Measures were the Pepper Assessment...