A5024199124- Frailty in Older Adults
- Nutrition and Health in Aging
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Pancreatic and Hepatic Oncology Research
- Body Composition Measurement Techniques
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Cancer Treatment and Pharmacology
- Occupational and environmental lung diseases
- Cancer Risks and Factors
- Colorectal Cancer Treatments and Studies
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Family Support in Illness
- Multiple Myeloma Research and Treatments
- Cancer-related cognitive impairment studies
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Health and Wellbeing Research
- Reformation and Early Modern Christianity
University of Alabama at Birmingham
2017-2025
University of Alabama System
2025
O'Neal Comprehensive Cancer Center
2021-2024
Carleton University
2016-2024
Illinois College
2024
University of Illinois Urbana-Champaign
2024
The Ohio State University
2023
Luxembourg Institute of Health
2023
Odense University Hospital
2023
Royal Marsden Hospital
2023
Background Senescent cells, which express p16INK4a , accumulate with aging and contribute to age-related pathology. To understand whether cytotoxic agents promote molecular aging, we measured expression of other senescence markers in breast cancer patients treated adjuvant chemotherapy.
Severe skeletal muscle (SM) loss (sarcopenia) is associated with poor cancer outcomes, including reduced survival and increased toxicity. This study investigates SM measures in metastatic breast (MBC) patients receiving first-line taxane-based chemotherapy evaluates associations treatment toxicity other outcomes.Using computerized tomography (CT) images taken for the evaluation of disease burden, area (SMA), density (SMD) were measured at third lumbar vertebrae. Sarcopenia was defined as...
Abstract Background. We investigated whether a brief geriatric assessment (GA) would identify important patient deficits that could affect treatment tolerance and care outcomes within sample of older cancer patients rated as functionally normal (80%–100%) on the Karnofsky performance status (KPS) scale. Methods. Cancer aged ≥65 years were assessed using GA included both professionally patient-scored KPS measures comorbidity, polypharmacy, cognition, function, nutrition, psychosocial status....
For patients with cancer who are older than 65 years, the 2018 ASCO Guideline recommends geriatric assessment (GA) be performed. However, there limited data on providers' practices using GA. Therefore, ASCO's Geriatric Oncology Task Force conducted a survey of providers to assess practice patterns and barriers
The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing risks benefits treatment, preventing or decreasing complications from therapy, managing patients deemed be at high risk treatment-related toxicity. CGA is a multidisciplinary, in-depth evaluation that assesses objective health adult while evaluating multiple domains, which may affect prognosis...
This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents most common histologic form of disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical radiation and radiology is necessary. Primary treatment perianal cancer canal are similar include chemoradiation in cases. Follow-up clinical evaluations recommended all patients with carcinoma because additional curative-intent...
Because of the escalating cost cancer care coupled with high insurance deductibles, premiums, and uninsured populations, patients are affected by treatment-related financial harm, known as toxicity. The purpose this study was to describe individuals reporting toxicity identify rates reasons for affordability-related treatment noncompliance.
Abstract Purpose: Poor body composition metrics (BCM) are associated with inferior cancer outcomes; however, in early breast (EBC), there is a paucity of evidence regarding the impact BCM on toxicities. This study investigates associations between and treatment-related toxicity patients EBC receiving anthracyclines taxane–based chemotherapy. Experimental Design: Pretreatment computerized tomographic (CT) images were evaluated for skeletal muscle area (SMA), density (SMD), fat tissue at third...
Background: An objective measure is needed to identify frail older adults with cancer who are at increased risk for poor health outcomes. The primary of this study was develop a frailty index from cancer-specific geriatric assessment (GA) and evaluate its ability predict all-cause mortality among cancer. Patients Methods: Using unique novel data set that brings together GA long-term data, we developed the Carolina Frailty Index (CFI) based on principles deficit accumulation. CFI scores...
// Grant R. Williams 1, 2 , Allison M. Deal 3 Hyman B. Muss 2, Marc S. Weinberg Hanna K. Sanoff Kirsten A. Nyrop Mackenzi Pergolotti 4 Shlomit Strulov Shachar 5 1 The University of Alabama at Birmingham, AL, USA North Carolina Chapel Hill, NC, UNC Lineberger Comprehensive Cancer Center, Colorado State University, Fort Collins, CO, Division Oncology, Rambam Health Care Campus, Haifa, Israel Correspondence to: Williams, email: gwillia@uab.edu Keywords: sarcopenia, myopenia, skeletal muscle...