A5019517698- Frailty in Older Adults
- Cancer survivorship and care
- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Palliative Care and End-of-Life Issues
- Cancer Risks and Factors
- Childhood Cancer Survivors' Quality of Life
- Chronic Disease Management Strategies
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
- Occupational and environmental lung diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Economic and Financial Impacts of Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Lymphatic System and Diseases
- Colorectal Cancer Screening and Detection
- Geriatric Care and Nursing Homes
- Medication Adherence and Compliance
- Colorectal Cancer Treatments and Studies
- Balance, Gait, and Falls Prevention
- Advanced Breast Cancer Therapies
Case Western Reserve University
2015-2024
University School
2012-2024
University Hospitals of Cleveland
2009-2024
University Hospitals Seidman Cancer Center
2009-2023
Case Comprehensive Cancer Center
2011-2023
Western University of Health Sciences
2014-2022
Cancer Institute (WIA)
2021
Cleveland Clinic
2021
University Hospitals Cleveland Medical Center
2009-2018
University of Nebraska–Lincoln
2018
Older adults are vulnerable to chemotherapy toxicity; however, there limited data identify those at risk. The goals of this study risk factors for toxicity in older and develop a stratification schema toxicity.Patients age ≥ 65 years with cancer from seven institutions completed prechemotherapy assessment that captured sociodemographics, tumor/treatment variables, laboratory test results, geriatric variables (function, comorbidity, cognition, psychological state, social activity/support,...
Five years of adjuvant tamoxifen therapy for estrogen receptor (ER) -positive breast cancer is more effective than 2 use. However, information on discontinuation scanty. We sought to identify predictors among older women with cancer.Within six health care delivery systems, we identified >or= 65 old diagnosed stage I IIB ER-positive or indeterminant between 1990 and 1994 who had filled a prescription tamoxifen. observed them 5 after initial prescription. used automated pharmacy records...
BACKGROUND Frailty has been suggested as a construct for oncologists to consider in treating older cancer patients. Therefore, the authors assessed potential of creating deficit‐accumulation frailty index (DAFI) from largely self‐administered comprehensive geriatric assessment (CGA). METHODS Five hundred patients aged ≥65 years underwent CGA before receiving chemotherapy. A DAFI was constructed, resulting 51‐item scale, and cutoff values were examined robust/nonfrail (cutoff value, 0.0 <...
The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing risks benefits treatment, preventing or decreasing complications from therapy, managing patients deemed be at high risk treatment-related toxicity. CGA is a multidisciplinary, in-depth evaluation that assesses objective health adult while evaluating multiple domains, which may affect prognosis...
To evaluate the prevalence of polypharmacy and potentially inappropriate medication (PIM) use association between these chemotherapy-related adverse events in older adults with cancer undergoing chemotherapy.Secondary analysis prospectively collected data.Outpatient oncology clinics seven academic medical centers.Adults aged 65 chemotherapy.Measures included number daily medications (polypharmacy); PIM based on three indices (Beers, Zhan, Drugs to Avoid Elderly criteria), six "high risk"...
Objective In older men with prostate cancer, aging is associated reduced anxiety and increased depression. The purpose of this study was to examine the association among age, anxiety, depression in a cohort adults receiving chemotherapy. Methods This secondary analysis prospective longitudinal investigating chemotherapy toxicity cancer. Baseline data (pre-chemotherapy) included: sociodemographics, tumor treatment factors, functional status, comorbidities, psychological state (measured by...
Multimorbidity is common among middle-aged and older adults; however the prospective effects of multimorbidity on health outcomes (health status, major decline, mortality) have not been fully explored. This study addresses this gap in literature.We used self-reported data from 2008 2010 Health Retirement Study. Our population included 13,232 adults aged 50 or older. measure baseline was based occurrence co-occurrence chronic conditions, functional limitations, and/or geriatric syndromes, as...
Importance Nearly 10% of the 1.5 million persons residing in nursing homes (NHs) have received or will receive a diagnosis cancer. Although aggressive end-of-life (EOL) care is common among community-dwelling patients with cancer, little known about such patterns NH residents Objective To compare markers EOL between older adults metastatic cancer who are and their counterparts. Design, Setting, Participants This cohort study used Surveillance, Epidemiology, End Results database linked...
Cancer care at the extremes of life, in young and old, is characterized by unique issues associated with pediatrics geriatric medicine, accentuated special vulnerabilities these groups.In response to needs, field pediatric oncology has been well honed deal problems juvenile cancer patients.While most adult oncologists consider themselves prepared older patients, current expansion population -their variable levels fitness, frailty vulnerability, fact that primarily a disease adults,...
To examine patterns of colorectal cancer (CRC) treatment and survival in relation to comorbidities (COM), functional limitations (FL), geriatric syndromes (GS).Our study population consisted Ohio elders diagnosed with incident invasive CRC the period August 1999 November 2001 admitted home health care (HHC) 30 days before or after diagnosis (n = 1009). We used data from Cancer Incidence Surveillance System, vital records, Medicare administrative data, including HHC Outcome Assessment...
Abstract Learning Objectives Compare characteristics of older patients that receive bevacizumab plus chemotherapy to those treated with alone for advanced NSCLC and CRC. outcomes between Describe toxicities in Background. Bevacizumab leads improved survival metastatic colorectal cancer (CRC) or non-small cell lung (NSCLC) when added chemotherapy. Little is known about factors associated receipt bevacizumab, whether bevacizamab increased toxicity Patients Methods. We conducted a prospective...
Abstract Chemotherapy treatment-related side-effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, depression, but it is unclear whether these important clinical outcomes, such as chemotherapy relative dose intensity (RDI). The National Cancer Institute funded Nutrition to Improve Treatment-Related Outcomes (ENICTO) Consortium, address this knowledge gap. This paper...
Background Nutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, unintentional weight loss (UWL) prior 6 months chemotherapy toxicity among solid tumors. Methods was a secondary analysis of prospective, multicenter involving chemotherapy‐treated patients 65 years old or older. Geriatric assessment, BMI, UWL data were collected before treatment. Multivariable...