A5087773842- Iron Metabolism and Disorders
- Trace Elements in Health
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer, Hypoxia, and Metabolism
- Erythropoietin and Anemia Treatment
- RNA regulation and disease
- Cancer Treatment and Pharmacology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Testicular diseases and treatments
- RNA Research and Splicing
- Sexual Differentiation and Disorders
- Cardiac Imaging and Diagnostics
Wake Forest University
2007-2023
UConn Health
2014-2023
Centre for Cancer Biology
1996-2023
University of Connecticut
2012-2021
Sorbonne Université
2006-2016
Virginia Commonwealth University
2015
Farmington Community Library
2014
University of Otago
2011
Karolinska Institutet
2011
Atrium Health Wake Forest Baptist
1995-2009
Certain infections and malignancies in mammals cause the development of a condition known as cachexia which animal continues to lose weight, often while consuming an adequate diet. When macrophages are stimulated with endotoxin, they produce factor or factors, termed cachectin, that inhibits activity fat-producing (lipogenic) enzymes cultured adipocytes. This effect may reflect one physiological bases for cachexia. In present study, clones complementary DNA from genes whose expression is...
Purpose Antiandrogen withdrawal (AAWD) results in a prostate-specific antigen (PSA) response (decline PSA level of ≥ 50%) 15% to 30% androgen-independent prostate cancer (AiPCa) patients. Thereafter, adrenal androgen ablation with agents such as ketoconazole (K) is commonly utilized. The therapeutic effect AAWD alone was compared simultaneous and K therapy. Patients Methods AiPCa patients were randomized undergo (n = 132), or together (400 mg orally [po] tid) hydrocortisone (30 po each...
Ferritin is a spherical molecule composed of 24 subunits two types, ferritin H chain (FHC) and L (FLC). stores iron within cells, but it also circulates binds specifically saturably to variety cell types. For most this binding can be mediated by only FHC (HFt) not FLC (LFt), indicating that cells FLC. By using expression cloning, we identified human transferrin receptor-1 (TfR1) as an important receptor for HFt with little or no LFt. In vitro, precipitated soluble TfR1, showing interaction...
Iron is required for normal cell growth and proliferation. However, excess iron potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry. For this reason, cells have evolved highly regulated mechanisms controlling intracellular levels. Chief among these sequestration in ferritin. Ferritin a 24 subunit protein composed two types, termed H L. The ferritin has potent ferroxidase activity that catalyses oxidation ferrous iron, whereas L...
An iron efflux pump is a pivotal protein in breast cancer biology and strong independent predictor of prognosis.
Fifty-eight patients with metastatic transitional cell carcinoma of the urinary tract received cisplatin, methotrexate, and vinblastine (CMV) combination chemotherapy. Complete responses (CRs) were noted in 14 50 (28%) evaluable partial (PRs) for an overall response rate 56% (95% confidence limits 42% to 70%). The median duration CRs was 9 months. Six (43%) remain unmaintained remission from 6 + 35 months onset treatment. survival receiving CMV 8 Median 11 v 7 PRs (P less than .05)...
Ferroportin and hepcidin are critical proteins for the regulation of systemic iron homeostasis. is only known mechanism export intracellular non–heme-associated iron; its stability regulated by hormone hepcidin. Although ferroportin profoundly affects concentrations in tissues important absorption trafficking, breast cancer their influence on growth prognosis have not been examined. We demonstrate here that both expressed cultured human epithelial cells regulates these cells. Further,...
Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate use MWCNTs to generate heat in response near-infrared radiation (NIR) results thermal destruction kidney vitro and vivo. We document the effects therapy through magnetic resonance temperature-mapping shock protein-reactive immunohistochemistry. Our enables ablation tumors with low laser powers (3...
Iron is required for normal cell growth and proliferation. However, excess iron potentially harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton chemistry. For this reason, cells have evolved highly regulated mechanisms controlling intracellular levels. Chief among these sequestration in ferritin. Ferritin a 24 subunit protein composed two types, termed H L. The ferritin has potent ferroxidase activity that catalyses oxidation ferrous iron, whereas L...