A5004885916- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cell death mechanisms and regulation
- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- RNA regulation and disease
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Amino Acid Enzymes and Metabolism
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Polyamine Metabolism and Applications
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
Sapienza University of Rome
2015-2024
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2017
Elisa (Finland)
2008
University of Chicago
2001-2007
May Institute
2001-2007
Istituto Pasteur
2004
University of L'Aquila
2004
University of Illinois Chicago
2003
University of Rome Tor Vergata
1996-1999
Bambino Gesù Children's Hospital
1997
Abstract Medulloblastoma is an aggressive brain malignancy with high incidence in childhood. Current treatment approaches have limited efficacy and severe side effects. Therefore, new risk‐adapted therapeutic strategies based on molecular classification are required. MicroRNA expression analysis has emerged as a powerful tool to identify candidate molecules playing important role large number of malignancies. However, no data yet available human primary medulloblastomas. A throughput...
Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss chromosome 17p has also been described as the most frequent genetic defect this human neoplasia. This observation raises question possible interplay between deletion and tumorigenic pathway. Here, we identify orthologue mouse REN(KCTD11), previously reported expressed differentiating low proliferating neuroblasts. Human...
Article4 December 2014Open Access Source Data Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors Paola Infante Center Life [email protected], Istituto Italiano di Tecnologia, Rome, Italy Search more papers by this author Mattia Mori Romina Alfonsi Department of Molecular Medicine, University La Sapienza, Francesca Ghirga Dipartimento Chimica e Tecnologie del Farmaco, Federica Aiello Chemistry and Industrial Chemistry, Pisa, Sara Toscano Cinzia Ingallina Mariangela Siler...
Aberrant Hedgehog/GLI signaling has been implicated in a diverse spectrum of human cancers, but its role lung adenocarcinoma (LAC) is still under debate. We show that the downstream effector Hedgehog pathway, GLI1, expressed 76% LACs, roughly half these tumors, canonical pathway activator, Smoothened, at low levels, possibly owing to epigenetic silencing. In LAC cells including cancer stem cell compartment, we GLI1 activated noncanonically by MAPK/ERK signaling. Different mechanisms can...
// Monica Benvenuto 1,* , Laura Masuelli 2,* Enrico De Smaele 2 Massimo Fantini 1 Rosanna Mattera 1,3 Danilo Cucchi 3 Elena Bonanno 4 Enrica Di Stefano Giovanni Vanni Frajese 5 Augusto Orlandi Isabella Screpanti Alberto Gulino Andrea Modesti and Roberto Bei Department of Clinical Sciences Translational Medicine, University Rome "Tor Vergata", Rome, Italy Experimental "Sapienza", Molecular Biomedicine Prevention, Physical Education, Human Health, "Foro Italico", * These authors have...
Medulloblastoma is the most common pediatric malignant brain tumor, arising from aberrant cerebellar precursors' development, a process mainly controlled by Hedgehog (Hh) signaling pathway. Histone deacetylase HDAC1 has been recently shown to modulate Hh signaling, deacetylating its effectors Gli1/2 and enhancing their transcriptional activity. Therefore, HDAC may represent potential therapeutic target for Hh-dependent tumors, but still little information available on physiological...
// Laura Masuelli 1 , Monica Benvenuto 2 Enrica Di Stefano Rosanna Mattera Massimo Fantini Giuseppina De Feudis Enrico Smaele Ilaria Tresoldi Maria Gabriella Giganti Andrea Modesti 2, 3 and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", Center for Regenerative (CIMER), Correspondence to: Bei, email: bei@med.uniroma2.it Keywords: curcumin, malignant mesothelioma, apoptosis, autophagy, proliferation...
ABSTRACT Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor regulated by hypusination, unique posttranslational modification catalyzed deoxyhypusine synthetase (DHPS) and hydroxylase (DOHH) starting from the polyamine spermidine. Emerging data are showing that hypusinated EIF5A regulates key cellular processes such as autophagy, senescence, homeostasis, energy metabolism, plays role in cancer. However, effects of inhibition preclinical cancer models, mechanism...
A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC and its targets, including ornithine decarboxylase (ODC), a master regulator polyamine metabolism. Elevated polyamines promote tumorigenesis in part by activating DHPS-mediated hypusination translation factor eIF5A, thereby inducing biosynthesis. Thus, MYC, ODC eIF5A orchestrate positive feedback loop that represents an attractive therapeutic target for CRC therapy. Here we show combined inhibition induces...