A5012646641- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Chemical Synthesis and Analysis
- Psoriasis: Treatment and Pathogenesis
- Cancer Treatment and Pharmacology
- Curcumin's Biomedical Applications
- T-cell and B-cell Immunology
- Helicobacter pylori-related gastroenterology studies
- Electromagnetic Fields and Biological Effects
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Terahertz technology and applications
- Microbial Inactivation Methods
- NF-κB Signaling Pathways
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
University of Cagliari
2024-2025
Azienda Ospedaliero-Universitaria Cagliari
2025
National Cancer Institute
2015-2023
Center for Cancer Research
2015-2023
University of Rome Tor Vergata
2006-2018
National Institutes of Health
2015-2018
Data Harbor (United States)
2015
Alexandria University
2014
Istituto Superiore di Sanità
2014
Sana'a University
2014
Colorectal cancers (CRCs) often show a dense infiltrate of cytokine-producing immune/inflammatory cells. The exact contribution each immune cell subset and cytokine in the activation intracellular pathways sustaining CRC growth is not understood. Herein, we isolate tumor-infiltrating leukocytes (TILs) lamina propria mononuclear cells (LPMCs) from tumor area macroscopically unaffected, adjacent, colonic mucosa patients who underwent resection for sporadic that culture supernatants TILs, but...
Several anti-PD-1/PD-L1 monoclonal antibodies (mAb) are currently providing evidence of clinical benefit in subsets cancer patients. The mode action these mAbs is to inhibit PD-1 on immune cells interacting with PD-L1 tumor cells. These either designed or engineered eliminate antibody-dependent cell-mediated cytotoxicity (ADCC), which, however, has been implicated as an important mechanism several highly effective mAb-mediated therapies. A fully human anti-PD-L1 mAb would potentially be able...
Natural killer (NK) cells are known to play a role in mediating innate immunity, enhancing adaptive immune responses, and have been implicated anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC) by reactivity of CD16 with the Fc region human IgG1 antibodies. The NK-92 cell line, derived from lymphoma patient, has previously well characterized adoptive transfer irradiated demonstrated safety shown preliminary evidence clinical benefit cancer patients. devoid CD16,...
<b>Background:</b> T cell-mediated immunity plays a central part in the pathogenesis of tissue damage inflammatory bowel disease (IBD). The mechanism by which cells mediate during IBD remains unclear, but evidence indicates that cell-derived cytokines stimulate fibroblasts to synthesise matrix metalloproteinases (MMPs), then mucosal degradation. We have previously shown that, IBD, there is high production interleukin (IL) 21, cytokine, enhances Th1 activity. <b>Aim:</b> To investigate...
Abstract Regulatory T (T reg ) cells play a key role in the maintenance of immune system homeostasis. can be generated periphery under control TGF‐β, cytokine involved negative system. However, TGF‐β cooperates with IL‐6 generation Th17 cells, novel class effector numerous inflammatory diseases, including colitis. Therefore, emerges as mediator both anti‐inflammatory and pro‐inflammatory processes, depending on local milieu. Here we demonstrate that IL‐21, type‐1 produced by pathogenesis...
Epacadostat is a novel inhibitor of indoleamine-2,3-dioxygenase-1 (IDO1) that suppresses systemic tryptophan catabolism and currently being evaluated in ongoing clinical trials. We investigated the effects epacadostat on (a) human dendritic cells (DCs) with respect to maturation ability activate tumor antigen-specific cytotoxic T-cell (CTL) lines, subsequent lysis cells, (b) regulatory T (Tregs), (c) peripheral blood mononuclear (PBMCs) vitro. Simultaneous treatment IFN-γ plus...
// Monica Benvenuto 1,* , Laura Masuelli 2,* Enrico De Smaele 2 Massimo Fantini 1 Rosanna Mattera 1,3 Danilo Cucchi 3 Elena Bonanno 4 Enrica Di Stefano Giovanni Vanni Frajese 5 Augusto Orlandi Isabella Screpanti Alberto Gulino Andrea Modesti and Roberto Bei Department of Clinical Sciences Translational Medicine, University Rome "Tor Vergata", Rome, Italy Experimental "Sapienza", Molecular Biomedicine Prevention, Physical Education, Human Health, "Foro Italico", * These authors have...
// Laura Masuelli 1 , Enrica Di Stefano Massimo Fantini 2 Rosanna Mattera Monica Benvenuto Marzocchella Pamela Sacchetti Chiara Focaccetti 3 Roberta Bernardini Ilaria Tresoldi Valerio Izzi Maurizio Mattei Giovanni Vanni Frajese 4 Florigio Lista 5 Andrea Modesti and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", STA, Dipartimento di Scienze Motorie, Umane e della Salute, Università Roma, Foro Italico...
Abstract Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT treating IBD, particularly ulcerative colitis (UC), still requires thorough clinical investigation. Notwithstanding differences in methodologies, current studies demonstrate inducing remission UC patients. Therefore, standardized and robust randomized trials (RCTs) are needed to...
<h3>Background</h3> Multiple anti-PD-L1/PD-1 checkpoint monoclonal antibodies (MAb) have shown clear evidence of clinical benefit. All except one been designed or engineered to omit the possibility mediate antibody-dependent cell-mediated cytotoxicity (ADCC) as a second potential mode anti-tumor activity; reason for this is concern lysis PD-L1 positive immune cells. Avelumab fully human IgG1 MAb which has in prior vitro studies ADCC versus range tumor cells, and demonstrated activity...
// Laura Masuelli 1 , Monica Benvenuto 2 Enrica Di Stefano Rosanna Mattera Massimo Fantini Giuseppina De Feudis Enrico Smaele Ilaria Tresoldi Maria Gabriella Giganti Andrea Modesti 2, 3 and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", Center for Regenerative (CIMER), Correspondence to: Bei, email: bei@med.uniroma2.it Keywords: curcumin, malignant mesothelioma, apoptosis, autophagy, proliferation...
Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail benefit most patients with carcinomas. This highlights need develop effective therapeutic strategies increase blockade. Histone deacetylase (HDAC) in combination have provided preliminary evidence of anti-tumor effects. We investigated here whether exposure either natural killer (NK) cells and/or two different classes HDAC...
We investigated 400 cases of dengue-like illness in persons hospitalized during an outbreak Al Hudaydah, Yemen, 2012. Overall, 116 dengue and 49 chikungunya were diagnosed. Dengue virus type 2 was the predominant serotype. The co-circulation these viruses indicates that mosquitoborne infections represent a public health threat Yemen.
Violacein (VIO; 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one), an indole-derived purple-colored pigment, produced by a limited number of Gram-negative bacteria species, including Chromobacterium violaceum and Janthinobacterium lividum, has been demonstrated to have anti-cancer activity, as it interferes with survival transduction signaling pathways in different cancer models. Head neck carcinoma (HNC) represents the sixth most common one...
// Veronica De Simone 1 , Giulia Ronchetti Eleonora Franzè Alfredo Colantoni Angela Ortenzi Massimo C. Fantini Angelamaria Rizzo Giuseppe S. Sica 2 Pierpaolo Sileri Piero Rossi Thomas T. MacDonald 3 Francesco Pallone Giovanni Monteleone and Carmine Stolfi Department of Systems Medicine, University Rome "Tor Vergata", Rome, Italy Surgery, Centre for Immunology Infectious Disease, Blizard Institute Cell Molecular Science, Barts the London School Medicine Dentistry, London, UK Correspondence...
NK-92 cells, and their derivative, designated aNK, were obtained from a patient with non-Hodgkin lymphoma. Prior clinical studies employing adoptively transferred irradiated aNK cells have provided evidence of benefit an acceptable safety profile. now been engineered to express IL-2 the high affinity (ha) CD16 allele (designated haNK). Avelumab is human IgG1 anti–PD-L1 monoclonal antibody, which has shown activity in range tumors. vitro that avelumab ability mediate antibody-dependent...
Abstract Glycosylation is a vital post-translational modification of proteins and lipids in mammalian cells involved cell–matrix interactions, cell recognition, intracellular signaling. One glycosylation pattern often disrupted during the process carcinogenesis O-glycosylation. This phenomenon leads to expression incomplete or truncated O-glycans on cancer cells, particularly cancers epithelial origin, including breast, ovarian, gastric, pancreatic, colon cancers. alteration supports tumor...
Abstract Introduction: The three essential components of an ADC include the mAb, linker, and cytotoxic payload. mAb is designated to target specific tumor-associated antigens that are overexpressed on surface cancer cells. PB-223 was developed through affinity maturation NEO-102, a chimeric human IgG1 specifically targets truncated Core-2 O-glycans, found in colorectal pancreatic cancers. binding for its improved, compared by optimizing VH VL sequences Fast Screening Expression Biophysical...