A5051347954- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Probiotics and Fermented Foods
- Diverticular Disease and Complications
- Diet and metabolism studies
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders
- Digestive system and related health
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- COVID-19 and healthcare impacts
- Biosimilars and Bioanalytical Methods
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
University of Chieti-Pescara
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Agostino Gemelli University Polyclinic
2016-2025
Università Cattolica del Sacro Cuore
2016-2025
University of the Sacred Heart
2025
Link Campus University
2025
Centro Clinico Nemo
2022-2023
University of Milano-Bicocca
2022
University School
2012-2018
Case Western Reserve University
2012-2018
The gastrointestinal tract is a complex and dynamic network where an intricate mutualistic symbiosis modulates the relationship between host microbiota in order to establish ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria phylum Firmicutes make up substantial part total microbiota. They start colonize intestine breastfed infants during first month life populate specific region intestinal mucosa close with cells. This position allows them participate...
Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly ulcerative colitis, have recently been published, but with major variations in study design. These include differences administered dose, route and frequency delivery, type placebo evaluated endpoints. Although overall outcomes appear to be promising, they are highly dependent on both donor recipient factors. Objective To...
Malnutrition is a major complication of inflammatory bowel disease (IBD). This mini review focusing on main determinants malnutrition in IBD, the most important components malnutrition, including lean mass loss and sarcopenia, as an emerging problem. Each one these needs to be well considered correct nutritional evaluation IBD patient order build multidisciplinary approach. The then possible instrumental clinical armamentarium for evaluation.
Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory diseases (IBD) patients. DD, IBS, IBD patients along with healthy controls (CT) were enrolled our Italian GI outpatient clinic. Stool samples collected. Microbiota was through a metagenomic gene-targeted approach. pathology represented continuous spectrum of where displayed one...
Summary Background Faecal microbiota transplantation ( FMT ) is a highly effective treatment against recurrent Clostridium difficile infection. Far less evidence exists on the efficacy of in treating severe infection refractory to antibiotics. Aim To compare two ‐based protocols associated with vancomycin curing subjects Methods Subjects antibiotics were randomly assigned one following arms: (1) ‐S, including single faecal infusion via colonoscopy followed by 14‐day course, (2) ‐M, multiple...
In addition to their well-established role(s) in the pathogenesis of gastrointestinal (GI)-related inflammatory disorders, including bowel disease (IBD) and inflammation-associated colorectal cancer (CRC), emerging evidence confirms critical involvement interleukin-1 (IL-1) cytokine family ligands maintenance normal gut homeostasis. fact, paradigm that IBD occurs two distinct phases is substantiated by observation classic IL-1 members, such as IL-1, receptor antagonist (IL-1Ra), IL-18,...
Significance We clarify that the normal, inherent function of IL-33 following acute, resolving colitis is protection, inducing proliferation and restitution ST2L-bearing intestinal epithelial cells (IECs). Importantly, this response occurs in otherwise healthy, immunocompetent C57BL/6J (B6) mice may be different other models possessing genetic and/or immunologic abnormalities predispose to colitis, similar patients with inflammatory bowel disease. Mechanistically, although molecular...
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Autoimmune Disorder Associated with Streptococcal Infections (PANDAS) are conditions that impair brain normal neurologic function, resulting in the sudden onset of tics, obsessive compulsive disorder, other behavioral symptoms. Recent studies have emphasized crosstalk between gut brain, highlighting how composition can influence behavior functions. Thus, present study investigates relationship PANS/PANDAS microbiota ecology. The a...
Abstract Diarrhoea is one of the most burdensome and common adverse events chemotherapeutics, has no standardised therapy to date. Increasing evidence suggests that gut microbiome can influence development chemotherapy-induced diarrhoea. Here we report findings from a randomised clinical trial faecal microbiota transplantation (FMT) treat diarrhoea induced by tyrosine kinase inhibitors (TKI) in patients with metastatic renal cell carcinoma (ClinicalTrials.gov number: NCT04040712). The...