A5019926598- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Advanced Proteomics Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- Bone and Dental Protein Studies
- Cancer Immunotherapy and Biomarkers
- Proteoglycans and glycosaminoglycans research
- TGF-β signaling in diseases
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cancer Genomics and Diagnostics
- Occupational and environmental lung diseases
- Retinoids in leukemia and cellular processes
- Hair Growth and Disorders
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- Renal and related cancers
University of Oulu
2016-2025
Oulu University Hospital
2014-2024
Cancer Society of Finland
2022-2023
Cancer Institute (WIA)
2023
Matrix Research (United States)
2014-2022
Finnish Cancer Registry
2022
Biocenter Finland
2014-2016
University of Rome Tor Vergata
1992-2014
Significance Statement The population frequencies of Alport syndrome vary greatly in different reports. This study examined a sequencing database individuals not known to have kidney disease using filtering steps corresponding the American College Medical Genetics and Genomics/Association for Molecular Pathology criteria “predicted pathogenic” variants COL4A3–COL4A5 , which considered collagen chain position 1 Gly residues “critical domains.” Predicted pathogenic COL4A5 occurred at least one...
The sirtuins (SIRTs; SIRT1-7) are a family of NAD(+)-dependent enzymes that dynamically regulate cellular physiology. Apart from SIRT1, the functions and regulatory mechanisms SIRTs poorly defined. We explored regulation SIRT by 2 energy metabolism-controlling factors: peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) AMP-activated protein kinase (AMPK). Overexpression PGC-1α in mouse primary hepatocytes increased SIRT5 mRNA expression 4-fold also α (PPARα)-...
In bone marrow (BM), hematopoietic elements are mingled with adipocytes (BM-A), which the most abundant stromal component in niche. BM-A progressively increase aging, eventually occupying up to 50% of BM cavities. this work, role played by was explored studying primary human isolated from hip surgery patients at molecular level, through microarray analysis, and functional assessing their relationship stem cells (HSC) long-term culture initiating cell (LTC-IC) assay. Findings demonstrated...
// Laura Masuelli 1 , Enrica Di Stefano Massimo Fantini 2 Rosanna Mattera Monica Benvenuto Marzocchella Pamela Sacchetti Chiara Focaccetti 3 Roberta Bernardini Ilaria Tresoldi Valerio Izzi Maurizio Mattei Giovanni Vanni Frajese 4 Florigio Lista 5 Andrea Modesti and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", STA, Dipartimento di Scienze Motorie, Umane e della Salute, Università Roma, Foro Italico...
The extracellular matrix (ECM) is a master regulator of all cellular functions and major component the tumor microenvironment. We previously defined “matrisome” as ensemble genes encoding ECM proteins modulating structure or function. While compositional biomechanical changes in regulate cancer progression, no study has investigated genomic alterations matrisome cancers their consequences. Here, mining Cancer Genome Atlas (TCGA) data, we found that copy number mutations are frequent genes,...
ABSTRACT The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into TNC tumorigenesis, angiogenesis, immunity metastasis. In addition to high levels expression tumors, during chronic inflammation, bacterial viral infection, is also expressed lymphoid organs. This supports potential for control. Advances using murine models with engineered were...
The extracellular matrix (ECM) is a complex meshwork of proteins that forms the scaffold all tissues in multicellular organisms. It plays crucial roles aspects life - from orchestrating cell migration during development, to supporting tissue repair. also critical etiology or progression diseases. To study this compartment, we have previously defined compendium genes encoding ECM and ECM-associated for multiple We termed 'matrisome' further classified matrisome components into different...
Abstract Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that chains are an abundant product normal mammary gland basal ablation in a mouse tumour model inhibits progression by reducing proliferative potential These effects shown to be primarily cell autonomous, from loss normally produced which they growth enhancing ability surface proteoglycan glypican-1 act co-receptor for FGF2. Thus, mechanism is presented...
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly breast pancreatic cancer. Stromal-derived extracellular matrix (ECM) significantly altered desmoplasia, as such plays critical role driving cancer progression. Using fibroblast-derived matrices (FDMs), we show that cells have increased growth on associated FDMs, when compared to FDMs derived from non-malignant tissue (normal) fibroblasts. We assess the changes ECM...
Abstract Background Amino acid sequence characterization is a fundamental part of virtually any protein analysis, and creating concise clear topology schemes high importance in proteomics studies. Although numerous databases prediction servers exist, it challenging to incorporate data from various, sometimes contending, resources into publication-ready scheme. Results Here, we present the Protein Topology Deviser R package (ProToDeviseR) for automatic generation database accession numbers,...
Metformin inhibits ATP production in mitochondria and this may be involved the anti-hyperglycemic effects of drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates function electron transport chain maintains basal yield. We hypothesized metformin treatment could diminish through downregulation SIRT3 expression. Glucagon cAMP induced mRNA mouse primary hepatocytes. prevented induction by glucagon. Moreover, downregulated constitutive expression hepatocytes liver vivo....
Significance A previously unrecognized role is described for collagen XVIII—a ubiquitous, structurally complex basement membrane proteoglycan—in supporting preadipocyte differentiation and the maintenance of this differentiated state, hence size lipid-clearing/storage functions white adipose tissue depots. Specific lack medium long isoforms nonfibrillar in mice led to reduced adiposity, ectopic deposition fat liver, elevated very low-density lipoprotein-triglyceride levels. The finding a...
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines growth factors collectively referred as the matrisome.Studies on cancer matrisome have been performed for single or few neoplasms, but more systematic analysis is still missing.Here we present Pan-Cancer study gene expression 10,487 patients across 32 tumor types, supplemented with transcription (TFs) driver...
White adipocytes are plastic cells able to reversibly transdifferentiate into brown and epithelial glandular under physiologic stimuli in vivo. These properties could be used future for regenerative medicine, but incompletely explored their details. Here, we focused on of human mature (MA) combining gene expression profile through microarray analysis with morphologic data obtained by electron time lapse microscopy. Primary MA showed the classic morphology functional adipocytes. Notably,...
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement tumorigenesis has remained elusive. We show here that ColXVIII was markedly upregulated human breast (BC) closely associated with a poor prognosis high-grade BCs. discovered role for as modulator epidermal growth factor receptor tyrosine kinase (ErbB) signaling it forms...