A5053622284- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Muscle Physiology and Disorders
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Prenatal Screening and Diagnostics
- Bone and Joint Diseases
- Cancer Genomics and Diagnostics
- Alcohol Consumption and Health Effects
- Dietary Effects on Health
Icahn School of Medicine at Mount Sinai
2020-2024
New York Proton Center
2023
Marche Polytechnic University
2009-2018
New York University
2016-2018
Ospedali Riuniti di Ancona
2013
Mature adipocytes are generally considered terminally differentiated because they have lost their proliferative abilities. Here, we studied the gene expression and functional properties of mature isolated from human omental subcutaneous fat tissues. We also focused on dedifferentiated in culture morphologies changes with respect to adipocytes, stromal-vascular fraction (SVF)-derived mesenchymal stem cells (MSCs) bone marrow (BM)-derived MSCs. Isolated expressed cell reprogramming genes. They...
In bone marrow (BM), hematopoietic elements are mingled with adipocytes (BM-A), which the most abundant stromal component in niche. BM-A progressively increase aging, eventually occupying up to 50% of BM cavities. this work, role played by was explored studying primary human isolated from hip surgery patients at molecular level, through microarray analysis, and functional assessing their relationship stem cells (HSC) long-term culture initiating cell (LTC-IC) assay. Findings demonstrated...
Mesenchymal stem cells (MSCs) are promising candidates for cell therapy and tissue engineering. Increasing evidence suggests that MSCs isolated from fetal tissues more plastic grow faster than adult MSCs. In this study, we characterized human mesenchymal progenitor chorionic villi (CV) amniotic fluid (AF) during the first second trimesters, respectively, compared them with bone marrow-derived (BM). We evaluated 10 CV, AF, 6 BM samples expanded until reached senescence. used discarded...
// Upal Basu-Roy 1,* , Eugenia Han 2,* Kirk Rattanakorn 1 Abhilash Gadi Narendra Verma Giulia Maurizi Preethi H. Gunaratne 3 Cristian Coarfa 4 Oran D. Kennedy 5 Michael J. Garabedian 1,2 Claudio Basilico and Alka Mansukhani Department of Microbiology, NYU School Medicine, New York, NY, USA 2 Perlmutter Cancer Center, Langone Medical Biology Biochemistry, University Houston, Texas, Molecular Cellular Biology, Baylor College Orthopaedic Surgery, * These authors have contributed equally to this...
We have investigated foetal mesenchymal stem cells (MSCs) obtained from first-trimester chorionic villi (CV) and second-trimester amniotic fluid (AF), comparing them to adult bone marrow-derived MSCs.We report on cell population growth in human allogeneic serum (HS) platelet lysate (PL), immunophenotype, cytokine expression profile immunoregulatory activity, of these MSCs stimulated peripheral blood mononuclear lymphocyte subpopulations.Chorionic grow rapidly HS, with 20 populations...
White adipocytes are plastic cells able to reversibly transdifferentiate into brown and epithelial glandular under physiologic stimuli in vivo. These properties could be used future for regenerative medicine, but incompletely explored their details. Here, we focused on of human mature (MA) combining gene expression profile through microarray analysis with morphologic data obtained by electron time lapse microscopy. Primary MA showed the classic morphology functional adipocytes. Notably,...
Abstract The transcription factor (TF) yes-associated protein 1 (YAP1) is a major effector of the tumor suppressive Hippo signaling pathway and also necessary to maintain pluripotency in embryonic stem cells. Elevated levels YAP1 expression antagonize effects that normally represses function. High observed several types human cancers particularly prominent cancer cells (CSCs). cell TF Sox2, which marks maintains CSCs osteosarcomas (OSs), promotes by binding an intronic enhancer element...
Mature adipocytes have shown dynamic plasticity to be converted into fibroblast-like and lipid-free cells. After the dedifferentiation process, these cells re-entered cell cycle acquired a high proliferation potential, becoming valid source of stem However, many aspects cellular biosafety about dedifferentiated fat remained unclear. This study aimed elucidate their potential susceptibility malignant transformation ascertain safety for clinical use. To evaluate genomic stability adipocytes,...
Hepatic steatosis is a key initiating event in the pathogenesis of alcohol-associated liver disease (ALD), most detrimental organ damage resulting from alcohol use disorder. However, mechanisms by which induces remain incompletely understood. We have previously found that binging impairs brain insulin action, increased adipose tissue lipolysis unrestraining sympathetic nervous system (SNS) outflow. Here, we examined whether an impaired brain-SNS-adipose axis drives hepatic through...