A5081863585- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
- Metabolism and Genetic Disorders
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Diet and metabolism studies
- Coronary Interventions and Diagnostics
- Ocular Diseases and Behçet’s Syndrome
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- TGF-β signaling in diseases
- Aortic Thrombus and Embolism
- Health Promotion and Cardiovascular Prevention
- Cancer, Lipids, and Metabolism
- Cellular Mechanics and Interactions
University of Oulu
2011-2022
University of Eastern Finland
2018-2022
Oulu University Hospital
2014-2017
Institute of Clinical Research
2014
Biocenter Finland
2012
Inflammatory markers have been observed in proliferative diabetic retinopathy (PDR). We assessed vitreous concentrations of adhesion molecules and cytokines PDR non-diabetic controls plasma to differentiate local inflammation from the breakdown blood-retina barrier.38 patients with 16 macular hole or epiretinal membrane underwent vitrectomy. Vitreous soluble [sE-selectin, intercellular molecule (sICAM)-1 -3, platelet-endothelial cell (sPECAM)-1, sP-selectin, vascular (sVCAM)-1] [interleukin...
Significance A previously unrecognized role is described for collagen XVIII—a ubiquitous, structurally complex basement membrane proteoglycan—in supporting preadipocyte differentiation and the maintenance of this differentiated state, hence size lipid-clearing/storage functions white adipose tissue depots. Specific lack medium long isoforms nonfibrillar in mice led to reduced adiposity, ectopic deposition fat liver, elevated very low-density lipoprotein-triglyceride levels. The finding a...
HDL-mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have protective role in atherogenesis. However, the estimation of HDL-CEC based on vitro cell assays are laborious and hamper large-scale phenotyping.Here, we present cost-effective high-throughput nuclear magnetic resonance (NMR) spectroscopy method to estimate directly from serum. We applied new population-based study 7603 individuals including 574 who developed incident coronary heart disease (CHD)...
HDL particles can be structurally modified in atherosclerotic disorders associated with low cholesterol level (HDL-C). We studied whether the lipidome of main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species HDL2 HDL3 subfractions is premature coronary heart disease (CHD) or metabolic syndrome (MetS) families where common HDL-C predisposes to CHD. The was analyzed by LC-MS. Lysophosphatidylcholines were depleted linoleic acid relative more saturated...
Objective The potential of high-density lipoproteins (HDL) to facilitate cholesterol removal from arterial foam cells is a key function HDL. We studied whether efflux serum and HDL subfractions impaired in subjects with early coronary heart disease (CHD) or metabolic syndrome (MetS) families where low HDL-cholesterol level (HDL-C) predisposes CHD. Methods were isolated plasma by sequential ultracentrifugation. THP-1 macrophages loaded acetyl-LDL used the assay total HDL, HDL2, HDL3 serum....
Population subgrouping has been suggested as means to improve coronary heart disease (CHD) risk assessment. We explored here how unsupervised data-driven metabolic subgrouping, based on comprehensive lipoprotein subclass data, would work in large-scale population cohorts.We applied a self-organizing map (SOM) artificial intelligence methodology define subgroups detailed profiles population-based cohort (n = 5789) and utilised the trained SOM an independent 7607). identified four SOM-based of...
Observational findings for high-density lipoprotein (HDL)-mediated cholesterol efflux capacity (HDL-CEC) and coronary heart disease (CHD) appear inconsistent, knowledge of the genetic architecture HDL-CEC is limited.A large-scale observational study on associations other HDL-related measures with CHD largest genome-wide association (GWAS) HDL-CEC.Six independent cohorts were included follow-up data 14,438 participants to investigate incident (1,570 events). The GWAS was carried out in 20,372...
Context and objective. Lipoproteins are involved in the pathophysiology of several metabolic diseases. Here we focus on interplay between lipoprotein metabolism adiponectin with extension alcohol intake. Design subjects. Eighty-three low-to-moderate 80 heavy drinkers were studied. Plasma adiponectin, other biochemical extensive data measured. Self-organizing maps applied to characterize phenotypes their interrelationships measures consumption. Results. Alcohol consumption plasma had a strong...
Abstract High-density lipoprotein mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have protective role in atherogenesis. However, the estimation of HDL-CEC based on vitro cell assays are laborious and hamper large-scale phenotyping. Here, we present cost-effective high-throughput nuclear magnetic resonance (NMR) spectroscopy method to estimate directly from serum. We applied new population-based study 7,603 individuals including 574 who developed incident...