A5033398262- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Systemic Lupus Erythematosus Research
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Viral-associated cancers and disorders
- Retinopathy of Prematurity Studies
- Meningioma and schwannoma management
- Renal Diseases and Glomerulopathies
- Insect and Arachnid Ecology and Behavior
- Genomics and Rare Diseases
- Calpain Protease Function and Regulation
Oulu University Hospital
2016-2025
University of Oulu
2016-2025
Research Medical Center
2020
Institute of Clinical Research
2013
Biocenter Finland
2012
Purpose: Angiogenesis in diabetic retinopathy (DR) is a multifactorial process regulated by hypoxia-induced growth factors and inflammatory cytokines. In addition to the angiogenic switch, proteolytic processing altered synthesis of extracellular matrix are critical steps this disease. This study was performed evaluate levels metalloproteinase-2 metalloproteinase-9 (MMP-2 MMP-9), angiopoietin-1 angiopoietin-2 (Ang-1 Ang-2), vascular endothelial factor (VEGF), erythropoietin (EPO)...
Inflammatory markers have been observed in proliferative diabetic retinopathy (PDR). We assessed vitreous concentrations of adhesion molecules and cytokines PDR non-diabetic controls plasma to differentiate local inflammation from the breakdown blood-retina barrier.38 patients with 16 macular hole or epiretinal membrane underwent vitrectomy. Vitreous soluble [sE-selectin, intercellular molecule (sICAM)-1 -3, platelet-endothelial cell (sPECAM)-1, sP-selectin, vascular (sVCAM)-1] [interleukin...
Abstract. Purpose: Tafluprost is a new prostaglandin F 2α (PGF ) derivative in development for the treatment of glaucoma. first PGF analogue with preservative‐free formulation. Methods: This randomized, investigator‐masked, multicentre, crossover phase III study evaluated pharmacodynamics and safety preserved tafluprost 0.0015% eyedrops administered 4 weeks 43 patients open‐angle glaucoma or ocular hypertension. The primary variable was change from baseline overall diurnal intraocular...
Aims/Purpose: The purpose of this study was to identify new genetic associations anterior uveitis through genome‐wide association (GWAS). Methods: We conducted a GWAS meta‐analysis combining data from the FinnGen, Estonian Biobank and UK with total 12 205 cases 917 145 controls. A phenome‐wide performed investigate across phenotypes traits. Genetic correlations were evaluated. Results: detected six associated genomic regions significance ( p < 5 × 10 ‐8 ). Three novel loci identified:...
Aims/Purpose: The purpose of this study was to identify new genetic associations anterior uveitis through genome‐wide association (GWAS). Methods: We conducted a GWAS meta‐analysis combining data from the FinnGen, Estonian Biobank and UK with total 12 205 cases 917 145 controls. A phenome‐wide performed investigate across phenotypes traits. Genetic correlations were evaluated. Results: detected six associated genomic regions significance ( p < 5 × 10 ‐8 ). Three novel loci identified:...
<h3>Background:</h3> In diabetic retinopathy, the vascular endothelium is damaged due to oxidative stress and inflammation, vitreous VEGF concentration becomes elevated. The association of retinopathy with single nucleotide polymorphisms (SNPs) was studied on two genes: VEGF, an important mediator neovascularisation, MnSOD, a major antioxidant enzyme. <h3>Methods:</h3> study population 755 individuals consisting 131 (type 1 or type 2) patients (DR group), 98 controls without (DC group) 526...
The efficacy, safety and tolerability of the preservative-free (PF) fixed combination (FC) tafluprost 0.0015% timolol 0.5% (once daily) were compared to those individual components (PF once daily PF twice in patients with open-angle glaucoma or ocular hypertension inadequately controlled on prior prostaglandin monotherapy for 6 months. A stratified, double-masked, randomized, multicenter phase III study was conducted. total 189 users randomized within stratum (TS) receive either FC (n = 95)...
To study the association of single-nucleotide polymorphisms interleukin 8, vascular endothelial growth factor, erythropoietin, complement factor H, component C3, and LOC387715 genes with response to bevacizumab treatment in exudative age-related macular degeneration.Clinical records, smoking history, optical coherence tomography, angiographies 96 bevacizumab-treated degeneration patients were analyzed retrospectively. Blood DNA was collected. Based on disappearance intra- or subretinal fluid...
To evaluate the applicability of imaging devices (spectral-domain optical coherence tomography (Cirrus SD-OCT), scanning laser polarimetry (GDx) and ophthalmoscopy (Heidelberg Retinal Tomograph, HRT3)) for glaucoma screening in a middle-aged unselected population.Participants population-based Northern Finland Birth Cohort Eye Study, aged 45 to 49 years, underwent comprehensive eye examination including modern with five methods (retinal nerve fibre layer (RNFL) macular ganglion cell +inner...
Abstract The net mass transfer (NMT) of cholesteryl esters (CEs), triglycerides (TGs), and phospholipids (PLs) between lipoproteins was measured after incubation fresh plasma for up to 2 hours from 18 male alcohol abusers 17 volunteer control subjects. In the mean value CE NMT 3.7 nmol·mL −1 ·h apolipoprotein B–containing (apoB-containing lipoproteins) HDL in subjects 8.7 nmol · mL h apoB-containing lipoproteins. PL higher than (35.0 vs 11.6 HDL, respectively), protein (TP) activity 33% ( P...
Amblyopia is a common visual disorder that treatable in childhood. However, therapies have limited efficacy adult patients with amblyopia. Fluoxetine can reinstate early-life critical period-like neuronal plasticity and has been used to recover functional vision rats We conducted Phase 2, randomized (fluoxetine vs. placebo), double-blind, multicenter clinical trial examined whether or not fluoxetine improve acuity amblyopic adults. This interventional included 42 participants diagnosed...
Background/Aim The aim of this study was to evaluate the effect prediabetes and diabetes on macular thickness retinal vascular calibres in our population-based cohort (Northern Finland Birth Cohort). Methods population 2005 individuals divided into (n=57), (n=1638) normal glucose metabolism (NGM) groups (n=310). Total macula measured using Cirrus HD-OCT 4000. Central arteriolar equivalent (CRAE) central venular (CRVE) were from fundus images. diagnosis made according WHO 2006 diagnostic...
Background. Vascular endothelial growth factor (VEGF) plays an important role in the development of diabetic retinopathy. Previous studies have suggested that angiotensin‐converting enzyme (ACE) inhibitor therapy may reduce vitreous VEGF concentration Also HMG CoA reductase inhibitors (statins), known for their beneficial effects on vascular endothelium, might influence
Plasma lipid concentrations cannot properly account for the complex interactions prevailing in lipoprotein (patho)physiology. Sequential ultracentrifugation (UCF) is gold standard physical isolations allowing subsequent analyses of molecular composition particles. Due to labor and cost issues, however, UCF-based are usually done only VLDL, LDL, HDL fractions; sometimes with addition intermediate density (IDL) particles fractionation into HDL(2) HDL(3) (as here; n = 302). We demonstrate via...
The evaluation of visual acuity (VA) and refraction in the Northern Finland Birth Cohort Eye study was performed using Nidek AR-360A autorefractometer. accuracy method for this population-based screening assessed. Measurements refractive error were obtained from right eyes 1238 subjects (mean age 47), first objectively with then subjectively by an optometrist. Agreement subjective calculated sphere, cylinder, mean spherical equivalent (MSE), cylindrical vectors J45 J0 presbyopic correction...
Purpose The aim of this study was to compare the measurements intraocular pressure by two tonometers, Icare rebound tonometer and Goldmann applanation tonometer, in a randomised screening study. influence refraction central corneal thickness on also evaluated. Methods Intraocular measured with 1266 participants; were determined. One eye each participant selected for report’s analysis. A Bland–Altman plot used values obtained devices. Results correlation between good: intraclass coefficient...
The effect of apolipoprotein (apo) E phenotype on the concentration and chemical composition plasma lipoproteins was studied in 73 male alcohol abusers 50 controls. apo confirmed by genotyping to avoid possible effects posttranslational modifications or its metabolites. lipid protein concentrations both intermediate density lipoprotein low were lower among than controls, those with E4 having highest masses groups. In only high (HDL)-2 higher controls respective group, whereas HDL2 HDL3 other...
Alcohol use is known to increase high-density lipoprotein (HDL) cholesterol, which at least in part mediated by the alcohol-induced reduction plasma cholesteryl ester transfer protein (CETP) activity and mass. We have shown that high HDL concentration reduces CETP-mediated net mass of esters from very-low-density (VLDL) low-density (LDL), or even reverses direction incubations. Therefore, we studied effect composition on lipid transfers 14 male alcohol abusers nine control subjects...