A5013666222- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Semantic Web and Ontologies
- Neonatal and fetal brain pathology
- Digital Humanities and Scholarship
- Mitochondrial Function and Pathology
- Natural Language Processing Techniques
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Library Science and Information Systems
- Genetics and Neurodevelopmental Disorders
- Digital and Traditional Archives Management
- Research in Social Sciences
- Peripheral Neuropathies and Disorders
- Herpesvirus Infections and Treatments
- Glioma Diagnosis and Treatment
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Functional Brain Connectivity Studies
- Neuroscience of respiration and sleep
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Neural dynamics and brain function
- Management of metastatic bone disease
Aalto University
2019-2024
Oulu University Hospital
2015-2024
University of Oulu
2015-2024
University of Helsinki
2004-2021
Center for Special Minimally Invasive and Robotic Surgery
2015
Tampere University Hospital
1997-2012
Tampere University
1996-2012
Helsinki University Hospital
2002-2008
Public Health Institute
2004
Agrifood Research Finland
2004
A population-based survey was conducted among 152,732 Finnish children and adolescents aged under 16 years living in northern Finland. Diagnoses associated medical conditions were derived from the hospital institutional records of this area. One hundred eighty-seven with DSM-IV autistic disorder identified. Associated disorders or known suspected genetic origin found 12.3 percent, including tuberous sclerosis, Down syndrome, fragile X Klinefelter XYY chromosome 17 deletion, 46, XX, dup(8)...
Signal intensity changes in fMRI during rest caused by vasomotor fluctuations were investigated this work. Resting-state baseline evaluated 12 children anesthetized with thiopental. Five subjects had related to subvoxel motion. In seven without significant motion, slow signal fluctuation at 0.025–0.041 Hz near one or more primary sensory cortices was observed. each subject the amplitude and frequency of stable. It is hypothesized that thiopental, which reduces blood pressure flow cortex,...
<b><i>Objective:</i></b> To investigate the efficacy of nasal sumatriptan in migraine attacks children and adolescents. <b><i>Methods:</i></b> A double-blind, placebo-controlled, two-way crossover trial was conducted three hospital outpatient departments, with 8 to 17 year olds diagnosed serving as subjects (International Headache Society 1988). single dose spray a matching placebo were administered at home during two attacks. The 10 mg for body weight 20 39 kg those ≥40 kg. primary endpoint...
<h3>Objective</h3> To evaluate the efficacy of different antipyretic agents and their highest recommended doses for preventing febrile seizures. <h3>Design</h3> Randomized, placebo-controlled, double-blind trial. <h3>Setting</h3> Five hospitals, each working as only pediatric hospital in its region. <h3>Participants</h3> A total 231 children who experienced first seizure between January 1, 1997, December 31, 2003. The were observed 2 years. <h3>Interventions</h3> All episodes during...
Abstract Objective We studied the prevalence, segregation, and phenotype of mitochondrial DNA 3243A>G mutation in children a defined population Northern Ostrobothnia, Finland. Methods Children with diagnoses commonly associated diseases were ascertained. Blood from 522 selected was analyzed for 3243A>G. clinically examined. Information on health history before age 18 years collected previously identified adult patients Mutation segregation analysis buccal epithelial cells performed...
This paper presents a new software framework, Sampo-UI, for developing user interfaces semantic portals. The goal is to provide the end-user with multiple application perspectives Linked Data knowledge graphs, and two-step usage cycle based on faceted search combined ready-to-use tooling data analysis. For developer, Sampo-UI framework makes it possible create highly customizable, user-friendly, responsive using current state-of-the-art JavaScript libraries from SPARQL endpoints, while...
To determine whether febrile seizures cause mesial temporal sclerosis (MTS), the occurrence of MTS was evaluated in an unselected series patients with seizures.Twenty-four a prolonged first seizure, 8 unprovoked seizure after and 32 age-, sex-, handedness-matched control subjects single simple without later were selected from 329 followed up prospectively. The mean follow-up time 12.3 years by MR volumetry amygdala hippocampal formation qualitative analysis structures.None had MTS. total...
Summary: Purpose: To analyze the occurrence, outcome, and prognostic factors of infantile spasms (IS) Lennox‐Gastaut syndrome (LGS) in a defined population. Methods: All children treated because IS LGS Department Pediatrics, University Oulu, from January 1, 1976, until December 31, 1993, who came primary catchment area hospital were included. Detailed information concerning their individual pre‐, peri‐, postnatal medical histories laboratory examinations compiled. Results: Thirty‐seven (18...
Summary: Purpose: To study the prevalence and features of visual field constrictions (VFCs) associated with vigabatrin (VGB) in children. Methods: A systematic collection all children any history VGB treatment fifteen Finnish neuropediatric units was performed, were included after being able to cooperate reliably repeated tests by Goldmann kinetic perimetry. This inclusion criterion yielded 91 (45 boys; 46 girls) between ages 5.6 17.9 years. Visual extent <70 degrees temporal meridian...
Summary Purpose: Polymerase gamma (POLG) is the sole enzyme in replication of mitochondrial DNA (mtDNA). Numerous mutations POLG1 gene have been detected recently patients with various phenotypes including a classic infantile‐onset Alpers‐Huttenlocher syndrome (AHS). Here we studied molecular etiology juvenile‐onset AHS manifesting status epilepticus and liver disease three teenagers. Patients Methods: We examined 14‐ 17‐year‐old female siblings (patients 1 2) an unrelated 15‐year‐old girl...
Homozygous loss of DIAPH1 results in seizures, cortical blindness, and microcephaly syndrome (SCBMS). We studied 5 Finnish 2 Omani patients with presenting SCBMS, mitochondrial dysfunction, immunodeficiency.We sought to further characterize phenotypes disease mechanisms associated DIAPH1.Exome sequencing, genotyping haplotype analysis, B- T-cell phenotyping, vitro lymphocyte stimulation assays, analyses function, immunofluorescence staining for cytoskeletal proteins mitochondria, CRISPR-Cas9...