A5038251371- Semantic Web and Ontologies
- Library Science and Information Systems
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Digital Humanities and Scholarship
- Geographic Information Systems Studies
- Natural Language Processing Techniques
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Image Processing and 3D Reconstruction
- Web Data Mining and Analysis
- Blood properties and coagulation
- Biomedical Text Mining and Ontologies
- Human Mobility and Location-Based Analysis
- Data Quality and Management
- Acute Myeloid Leukemia Research
- Archaeological Research and Protection
- Erythropoietin and Anemia Treatment
- Erythrocyte Function and Pathophysiology
- Intelligence, Security, War Strategy
- Acute Lymphoblastic Leukemia research
- Conservation Techniques and Studies
- Multiple Myeloma Research and Treatments
- Hemostasis and retained surgical items
Aalto University
2014-2022
University of Helsinki
1967-2021
Finnish Red Cross
1972-2015
Helsinki University Hospital
1979-2001
Kainuun keskussairaala
1993
Päijät-Hämeen Keskussairaala
1982
Tampere University
1982
University of Cambridge
1976
This paper presents a new software framework, Sampo-UI, for developing user interfaces semantic portals. The goal is to provide the end-user with multiple application perspectives Linked Data knowledge graphs, and two-step usage cycle based on faceted search combined ready-to-use tooling data analysis. For developer, Sampo-UI framework makes it possible create highly customizable, user-friendly, responsive using current state-of-the-art JavaScript libraries from SPARQL endpoints, while...
S ummary . Important advances have been made in the treatment of haemophilia during past 30 years. We analysed data all known 163 patients with severe A living Finland 1930–79 order to study changes prognosis A. During period 50 years mean age at death has increased from 7.8 1930‐39 25.5 1970–79 and annual rate markedly decreased groups. The decline greatest under 10 age. In this group over per thousand 1940‐49 4.8 1970–79. inhibitors remained poor, however. Five six deaths last decade...
The Second World War (WW2) is arguably the most devastating catastrophe of human history, a topic great interest to not only researchers but general public. However, data about heterogeneous and distributed in various organizations countries making it hard utilize. In order create aggregated global views war, shared ontology infrastructure needed harmonize information silos. This makes possible share between publishers application developers, support analysis Digital Humanities research,...
Twenty-five of the 139 Finnish patients (18.0%) with severe haemophilia A alive in 1960 or born later have had an inhibitor against factor VIII. 19 110 and current prevalence is 17.3%. The incidence new inhibitors was 10.3 per thousand patient years for observation period starting from 1960, median 16 years. age dependent cumulative risk developing 22% at 10. There been no deaths bleeding since 1976, which has resulted a marked decrease mortality. annual death rate 5.8 life 1980-89 compared...
A new haemoglobin, Hb Helsinki, in which β82-Lys (EF6) is replaced by Met, was found a Finnish family. It associated with familial erythrocytosis, and the oxygen affinity of blood higher than normal. The equilibrium curves purified Helsinki HbA from same haemolysate have been determined under various conditions. 'Stripped' to show normal cooperativity, slightly low reduced Bohr effect at physiological pH. However, organic phosphates, 2,3-diphosphoglycerate (2,3-DPG) inositol hexaphosphate...
Hereditary thrombocytopenia in three families is reported. The defect was obviously transmitted as an autosomal dominant characteristic two of these. moderate and the bleeding symptoms were mild but life‐long duration. Platelet ‐ adhesiveness vivo vitro , clot‐retraction, ADP‐induced aggregation, platelet factor 3 activity–were normal all patients studied. survival autologous 51 Cr‐labelled platelets at lower limit or slightly shortened. In third family recessive inheritance seemed probable....
Bone marrow biopsies were made in 63 patients with polycythaemia vera and three primary myelofibrosis having polycythaemic blood pictures. The histological findings classified as follows: normal bone 14, hyperplastic 17, increased reticulin fibers 19, early 9 advanced 4 patients. In 12 of the biopsy was repeated after nine to 32 months. eight picture unchanged, showed progression myelofibrosis, one fibrotic changes possibly due a miselading specimen had disappeared. good correlation clinical...
Abstract Manuscripts are a crucial form of evidence for research into all aspects premodern European history and culture, there numerous databases devoted to describing them in detail. This descriptive information, however, is typically available only separate data silos based on incompatible models user interfaces. As result, it has been difficult study manuscripts comprehensively across these various platforms. To address this challenge, team manuscript scholars computer scientists worked...
Platelet function was studied in 17 patients with preleukaemia and the results were compared those of 28 other chronic myeloproliferative disorders. The test pattern included bleeding time (Ivy), platelet retention (Hellem II), PF-3 activity availability after exposure to ADP kaolin, ADP-, epinephrine-, collagen- ristocetin-induced aggregations. frequently impaired preleukemia. defects similar found most consistent finding defective aggregation. Patients thrombocytosis and/or increased...
Erythroid colony formation in vitro was studied 80 patients with erythrocytosis. 43 of the had polycythaemia vera (PV), 18 secondary erythrocytosis, 6 normal red cell mass, and 13 were regarded as unclassified. Spontaneous erythroid formation, absence exogenous erythropoietin cultures, discovered all PV, whereas no patient erythrocytosis or mass showed this phenomenon. 8 unclassified spontaneously formed colonies. 7 have been followed for 5 yr. 3 4 spontaneous growth but none without it can...
Summary A patient with congenital deficiency of the fibrin-stabilizing factor is reported.
We have studied haemostatic parameters in 12 patients with Cushing's syndrome. Three had prolonged bleeding times, and all seven whose times were measured 3-6 months after surgical treatment the postoperative shorter (mean 7.5 min) than pretreatment 12.3 min). In ADP- or adrenaline-induced aggregation second wave was lacking six degree of borderline subnormal five patients. One patient had, addition, a severe defect collagen-induced aggregation. However, thromboxane B2 production platelets...